Sensitive species-specific monitoring of a new triplatinum anti-cancer drug and its potential related compounds in spiked human plasma by cation-exchange HPLC-ICP-MS

2003 ◽  
Vol 18 (8) ◽  
pp. 884 ◽  
Author(s):  
V�ronique Vacchina ◽  
Laura Torti ◽  
Cecilia Allievi ◽  
Ryszard Lobinski
Keyword(s):  
Cation Exchange ◽  
Human Plasma ◽  
Cancer Drug ◽  
Sensitive Species ◽  
Spiked Human Plasma ◽  
Icp Ms ◽  
Anti Cancer ◽  
Species Specific ◽  
Related Compounds ◽  
Cation Exchange Hplc

Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography–mass spectrometry

2003 ◽  
Vol 795 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Gareth J Veal ◽  
Julie Errington ◽  
Julieann Sludden ◽  
Melanie J Griffin ◽  
Lisa Price ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Plasma ◽  
Actinomycin D ◽  
Cancer Drug ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Anti Cancer

Study of the Se-containing metabolomes in Se-rich yeast by size-exclusion—cation-exchange HPLC with the parallel ICP MS and electrospray orbital ion trap detection

Metallomics ◽  
2010 ◽  
Vol 2 (8) ◽  
pp. 535 ◽  
Author(s):  
Sandra Gil Casal ◽  
Johann Far ◽  
Katarzyna Bierla ◽  
Laurent Ouerdane ◽  
Joanna Szpunar
Keyword(s):  
Cation Exchange ◽  
Ion Trap ◽  
Size Exclusion ◽  
Icp Ms ◽  
Cation Exchange Hplc

scholarly journals Preconcentration and Detection of Gefitinib Anti-Cancer Drug Traces from Water and Human Plasma Samples by Means of Magnetic Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1196 ◽  
Author(s):  
Hadeer Borg ◽  
Dániel Zámbó ◽  
Heba Elmansi ◽  
Heba M. Hashem ◽  
Jenny Jehan Nasr ◽  
...  
Keyword(s):  
Particle Size ◽  
Magnetic Nanoparticles ◽  
Human Plasma ◽  
Cancer Drug ◽  
Quantitative Detection ◽  
Plasma Samples ◽  
Widespread Application ◽  
Human Plasma Samples ◽  
Relative Standard ◽  
Anti Cancer

Along of widespread application of anti-cancer drug Gefitinib (GEF), it appears in human body fluids as well as clinical wastewater. Consequently, a reliable and easy-to-adapt detection technique is of essential importance to quantify the drug in different media. The extraction and quantitative detection of anti-cancer drug Gefinitib (GEF) is demonstrated based on a straightforward and efficient magnetic nanoparticle-assisted preconcentration route from water and human plasma samples. Iron oxide magnetic nanoparticles (Fe3O4) have been prepared with an average particle size of 15 nm and utilized as extractible adsorbents for the magnetic solid-phase extraction (MSPE) of GEF in aqueous media. The method is based on MSPE and preconcentration of GEF followed by High-Performance Liquid Chromatography-Ultraviolet Detection (HPLC-UV). The yield of GEF extraction under the optimum MSPE conditions were 94% and 87% for water and plasma samples, respectively. The chromatographic separation was carried out isocratically at 25 °C on a Phenomenex C8 reversed phase column (150 mm × 4.6 mm, with 5 µm particle size). The proposed method was linear over concentration ranges of 15.0–300.0 and 80.0–600.0 ng/mL for water and plasma samples with limits of detection of 4.6 and 25.0 ng/mL in a respective order. Relative standard deviations (%RSD) for intra-day and inter-day were 0.75 and 0.94 for water samples and 1.26 and 1.70 for plasma samples, respectively. Using the magnetic nanoparticles (MNPs) as loaded drug-extractors made the detection of the anti-cancer drug environmentally friendly and simple and has great potential to be used for different drug-containing systems.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6
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