An artificial ionophore based on a polyhydroxylated steroid dimer

2002 ◽  
pp. 3066-3067 ◽  
Author(s):  
Francesco De Riccardis ◽  
Marcello Di Filippo ◽  
Davide Garrisi ◽  
Irene Izzo ◽  
Fabrizio Mancin ◽  
...  
Keyword(s):  
Polyhydroxylated Steroid

Cholest-4-en-4,16β,18,22R-tetrol-3-one 16,18-diacetate A novel polyhydroxylated steroid from the hydroid Eudendrium SP

1980 ◽  
Vol 21 (34) ◽  
pp. 3303-3304 ◽  
Author(s):  
G. Cimino ◽  
S. De Rosa ◽  
S. De Stefano ◽  
G. Sodano
Keyword(s):  
Polyhydroxylated Steroid

Polyhydroxylated steroid derivatives from the starfish Pentaceraster regulus

2020 ◽  
pp. 1-7
Author(s):  
Le Thi Vien ◽  
Tran Thi Hong Hanh ◽  
Tran Hong Quang ◽  
Nguyen Xuan Cuong ◽  
Do Thi Thao ◽  
...  
Keyword(s):  
Polyhydroxylated Steroid

scholarly journals Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide

Science ◽  
2013 ◽  
Vol 339 (6115) ◽  
pp. 59-63 ◽  
Author(s):  
Hans Renata ◽  
Qianghui Zhou ◽  
Phil S. Baran
Keyword(s):  
Therapeutic Index ◽  
Challenging Problem ◽  
Narrow Therapeutic Index ◽  
Carbon Centers ◽  
Innovative Methods ◽  
Polyhydroxylated Steroid ◽  
Efficient Access ◽  
Bond Homolysis ◽  
Scalable Synthesis ◽  
Oxygen Bond

Here, we report on a scalable route to the polyhydroxylated steroid ouabagenin with an unusual take on the age-old practice of steroid semisynthesis. The incorporation of both redox and stereochemical relays during the design of this synthesis resulted in efficient access to more than 500 milligrams of a key precursor toward ouabagenin—and ultimately ouabagenin itself—and the discovery of innovative methods for carbon-hydrogen (C-H) and carbon-carbon activation and carbon-oxygen bond homolysis. Given the medicinal relevance of the cardenolides in the treatment of congestive heart failure, a variety of ouabagenin analogs could potentially be generated from the key intermediate as a means of addressing the narrow therapeutic index of these molecules. This synthesis also showcases an approach to bypass the historically challenging problem of selective C-H oxidation of saturated carbon centers in a controlled fashion.

Polyhydroxylated steroid compounds from the Far Eastern starfish Distolasterias nipon

2008 ◽  
Vol 34 (1) ◽  
pp. 118-124 ◽  
Author(s):  
A. A. Kicha ◽  
I. I. Kapustina ◽  
N. V. Ivanchina ◽  
A. I. Kalinovsky ◽  
P. S. Dmitrenok ◽  
...  
Keyword(s):  
Polyhydroxylated Steroid ◽  
Far Eastern

An Artificial Ionophore Based on a Polyhydroxylated Steroid Dimer.

ChemInform ◽  
2003 ◽  
Vol 34 (13) ◽  
Author(s):  
Francesco De Riccardis ◽  
Marcello Di Filippo ◽  
Davide Garrisi ◽  
Irene Izzo ◽  
Fabrizio Mancin ◽  
...  
Keyword(s):  
Polyhydroxylated Steroid

New polyhydroxylated steroid from the South China Sea gorgonianAnthogorgia caerulea

2013 ◽  
Vol 27 (13) ◽  
pp. 1159-1166 ◽  
Author(s):  
Ling-Ling Sun ◽  
Chang-Lun Shao ◽  
Hui Hang ◽  
Zhi-Yong Guo ◽  
Qian Xing ◽  
...  
Keyword(s):  
South China Sea ◽  
South China ◽  
The South China Sea ◽  
The South ◽  
China Sea ◽  
Polyhydroxylated Steroid
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