Grafting of synthetic mannose receptor-ligands onto onion vectors for human dendritic cells targetingElectronic supplementary information (ESI) available: full experimental details. See http://www.rsc.org/suppdata/cc/b2/b206980f/

2002 ◽  
pp. 2446-2447 ◽  
Author(s):  
Pascale Chenevier ◽  
Cyrille Grandjean ◽  
Estelle Loing ◽  
Fr??d??ric Malingue ◽  
Gerhild Angyalosi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mannose Receptor ◽  
Supplementary Information ◽  
Receptor Ligands ◽  
Human Dendritic Cells

HIV gp120 receptors on human dendritic cells

Blood ◽  
2001 ◽  
Vol 98 (8) ◽  
pp. 2482-2488 ◽  
Author(s):  
Stuart G. Turville ◽  
Jim Arthos ◽  
Kelli Mac Donald ◽  
Garry Lynch ◽  
Hassan Naif ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Ex Vivo ◽  
Mannose Receptor ◽  
Lectin Receptor ◽  
Immunodeficiency Virus ◽  
Processing Pathways ◽  
Human Dendritic Cells ◽  
Hiv Gp120 ◽  
Hiv Envelope ◽  
Transfer Mechanisms

Abstract Dendritic cells (DCs) are important targets for human immunodeficiency virus (HIV) because of their roles during transmission and also maintenance of immune competence. Furthermore, DCs are a key cell in the development of HIV vaccines. In both these settings the mechanism of binding of the HIV envelope protein gp120 to DCs is of importance. Recently a single C-type lectin receptor (CLR), DC-SIGN, has been reported to be the predominant receptor on monocyte-derived DCs (MDDCs) rather than CD4. In this study a novel biotinylated gp120 assay was used to determine whether CLR or CD4 were predominant receptors on MDDCs and ex vivo blood DCs. CLR bound more than 80% of gp120 on MDDCs, with residual binding attributable to CD4, reconfirming that CLRs were the major receptors for gp120 on MDDCs. However, in contrast to recent reports, gp120 binding to at least 3 CLRs was observed: DC-SIGN, mannose receptor, and unidentified trypsin resistant CLR(s). In marked contrast, freshly isolated and cultured CD11c+ve and CD11c−ve blood DCs only bound gp120 via CD4. In view of these marked differences between MDDCs and blood DCs, HIV capture by DCs and transfer mechanisms to T cells as well as potential antigenic processing pathways will need to be determined for each DC phenotype.

The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells

1997 ◽  
Vol 27 (9) ◽  
pp. 2417-2425 ◽  
Author(s):  
Anneke J. Engering ◽  
Marina Cella ◽  
Donna Fluitsma ◽  
Manfred Brockhaus ◽  
Elizabeth C. M. Hoefsmit ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
High Capacity ◽  
Antigen Receptor ◽  
Mannose Receptor ◽  
Human Dendritic Cells ◽  
Broad Specificity

scholarly journals Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

Blood ◽  
2012 ◽  
Vol 120 (10) ◽  
pp. 2011-2020 ◽  
Author(s):  
Bithi Chatterjee ◽  
Anna Smed-Sörensen ◽  
Lillian Cohn ◽  
Cécile Chalouni ◽  
Richard Vandlen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Vaccine Development ◽  
Mannose Receptor ◽  
Antigen Delivery ◽  
Cross Presentation ◽  
Late Endosomes ◽  
Early Endosomes ◽  
Antibody Conjugates ◽  
Human Dendritic Cells ◽  
Endocytic Compartments

Abstract Dendritic cells (DCs) can capture extracellular antigens and load resultant peptides on to MHC class I molecules, a process termed cross presentation. The mechanisms of cross presentation remain incompletely understood, particularly in primary human DCs. One unknown is the extent to which antigen delivery to distinct endocytic compartments determines cross presentation efficiency, possibly by influencing antigen egress to the cytosol. We addressed the problem directly and quantitatively by comparing the cross presentation of identical antigens conjugated with antibodies against different DC receptors that are targeted to early or late endosomes at distinct efficiencies. In human BDCA1+ and monocyte-derived DCs, CD40 and mannose receptor targeted antibody conjugates to early endosomes, whereas DEC205 targeted antigen primarily to late compartments. Surprisingly, the receptor least efficient at internalization, CD40, was the most efficient at cross presentation. This did not reflect DC activation by CD40, but rather its relatively poor uptake or intra-endosomal degradation compared with mannose receptor or DEC205. Thus, although both early and late endosomes appear to support cross presentation in human DCs, internalization efficiency, especially to late compartments, may be a negative predictor of activity when selecting receptors for vaccine development.

Involvement of the mannose receptor in the uptake of der p 1, a major mite allergen, by human dendritic cells

2002 ◽  
Vol 110 (5) ◽  
pp. 763-770 ◽  
Author(s):  
Gaë tan Deslée ◽  
Anne-Sophie Charbonnier ◽  
Hamida Hammad ◽  
Gerhild Angyalosi ◽  
Isabelle Tillie-Leblond ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mannose Receptor ◽  
Mite Allergen ◽  
Der P 1 ◽  
Human Dendritic Cells

scholarly journals DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells

2002 ◽  
Vol 197 (1) ◽  
pp. 121-127 ◽  
Author(s):  
Ludovic Tailleux ◽  
Olivier Schwartz ◽  
Jean-Louis Herrmann ◽  
Elisabeth Pivert ◽  
Mary Jackson ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mycobacterium Tuberculosis ◽  
Human Monocyte ◽  
Mannose Receptor ◽  
Intercellular Adhesion Molecule ◽  
Minor Role ◽  
Hla Dr ◽  
A Minor ◽  
Human Dendritic Cells

Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterial immune response and for determining the outcome of infection. However, these interactions are poorly understood, at least at the molecular level. Here we show that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN). By contrast, complement receptor (CR)3 and mannose receptor (MR), which are the main M. tuberculosis receptors on macrophages (Mϕs), appeared to play a minor role, if any, in mycobacterial binding to DCs. The mycobacteria-specific lipoglycan lipoarabinomannan (LAM) was identified as a key ligand of DC-SIGN. Freshly isolated human LDCs were found to express DC-SIGN, and M. tuberculosis–derived material was detected in CD14−HLA-DR+DC-SIGN+ cells in lymph nodes (LNs) from patients with tuberculosis. Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN–mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity.

scholarly journals Human dendritic cells shed a functional, soluble form of the mannose receptor

1999 ◽  
Vol 11 (11) ◽  
pp. 1775-1780 ◽  
Author(s):  
Reina Jordens ◽  
Allan Thompson ◽  
Reinout Amons ◽  
Frits Koning
Keyword(s):  
Dendritic Cells ◽  
Mannose Receptor ◽  
Soluble Form ◽  
Human Dendritic Cells

Synthesis and mannose receptor-Mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge

2002 ◽  
Vol 12 (19) ◽  
pp. 2723-2727 ◽  
Author(s):  
Gerhild Angyalosi ◽  
Cyrille Grandjean ◽  
Mélanie Lamirand ◽  
Claude Auriault ◽  
Hélène Gras-Masse ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mannose Receptor ◽  
Human Dendritic Cells

scholarly journals Mannose Receptor Targeting of Tumor Antigen pmel17 to Human Dendritic Cells Directs Anti-Melanoma T Cell Responses via Multiple HLA Molecules

2004 ◽  
Vol 172 (5) ◽  
pp. 2845-2852 ◽  
Author(s):  
Venky Ramakrishna ◽  
John F. Treml ◽  
Laura Vitale ◽  
John E. Connolly ◽  
Thomas O’Neill ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Tumor Antigen ◽  
T Cell Responses ◽  
Mannose Receptor ◽  
Receptor Targeting ◽  
Cell Responses ◽  
Human Dendritic Cells ◽  
Hla Molecules

scholarly journals Differential regulation of CD103 (αE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands

2017 ◽  
Vol 101 (5) ◽  
pp. 1169-1180 ◽  
Author(s):  
Mandi M. Roe ◽  
Steve Swain ◽  
T. Andrew Sebrell ◽  
Marisa A. Sewell ◽  
Madison M. Collins ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Retinoic Acid ◽  
Differential Regulation ◽  
Integrin Expression ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Human Dendritic Cells

scholarly journals Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124089 ◽  
Author(s):  
Elsenoor J. Klaver ◽  
Loes M. Kuijk ◽  
Thisbe K. Lindhorst ◽  
Richard D. Cummings ◽  
Irma van Die
Keyword(s):  
Dendritic Cells ◽  
Schistosoma Mansoni ◽  
Mannose Receptor ◽  
Negative Regulators ◽  
Human Dendritic Cells
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