Wet chemical modification of PTFE implant surfaces with a specific cell adhesion molecule

2002 ◽  
pp. 2568-2569 ◽  
Author(s):  
Christoph Löhbach ◽  
Udo Bakowsky ◽  
Carsten Kneuer ◽  
Dieter Jahn ◽  
Thomas Graeter ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Chemical Modification ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Specific Cell ◽  
Wet Chemical

scholarly journals Molecular Basis for Leukocyte Integrin αEβ7 Adhesion to Epithelial (E)-Cadherin

2000 ◽  
Vol 191 (9) ◽  
pp. 1555-1567 ◽  
Author(s):  
Karen S. Taraszka ◽  
Jonathan M.G. Higgins ◽  
Kemin Tan ◽  
Didier A. Mandelbrot ◽  
Jia-huai Wang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Binding Site ◽  
Adhesion Molecule ◽  
Molecular Basis ◽  
Cell Adhesion Molecule ◽  
Intercellular Adhesion Molecule ◽  
Specific Cell ◽  
Lymphocyte Adhesion ◽  
Cell Adhesion Molecule 1 ◽  
E Cadherin

Cadherins are expressed in tissue-restricted patterns and typically mediate homophilic adhesion. Cadherins also mediate lymphocyte adhesion, providing the opportunity for lymphocyte attachment to parenchymal cells. The best characterized example of lymphocyte adhesion to a tissue-specific cell adhesion molecule, as opposed to a vascular endothelial adhesion molecule, is the interaction between integrin αEβ7 on intraepithelial lymphocytes and E-cadherin on epithelial cells. However, the molecular basis for an integrin–cadherin interaction is not well defined. Realization that the cadherin domain adopts a topology similar to the immunoglobulin (Ig) fold suggested that integrin recognition of E-cadherin might be similar to recognition of Ig superfamily ligands. Thus, we modeled domain 1 of human E-cadherin and studied the role of solvent-exposed loops that connect Ig-like core-forming β strands. Mutational analyses localized the integrin αEβ7 recognition site to the top of domain 1 at the face formed by the BC and FG loops, a site distinct from the region recognized in intercellular adhesion molecule (ICAM)-1, -2, and -3, mucosal addressin cell adhesion molecule 1 (MAdCAM-1), vascular cell adhesion molecule 1 (VCAM-1), and fibronectin by their integrin ligands. Moreover, the integrin αEβ7 binding site is distinct from the homophilic binding site on E-cadherin. These studies provide a conceptual basis for integrin–cadherin binding and extend the model that an Ig-like fold can serve as a scaffold for recognition.

scholarly journals Roles of a telencephalon-specific cell adhesion molecule in brain function

2000 ◽  
Vol 82 ◽  
pp. 107
Author(s):  
Kazuhiro Nakamura ◽  
Toshiya Manabe ◽  
Takayoshi Mamiya ◽  
Hisashi Mori ◽  
Yuji Kiyama ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Brain Function ◽  
Cell Adhesion Molecule ◽  
Specific Cell

Testis-Specific Cell Adhesion Molecule, CEACAM6-L, Forms Homophilic Interaction at the Cell Adhesion Site in Vitro

2012 ◽  
Vol 29 (11) ◽  
pp. 786-793 ◽  
Author(s):  
Hitoshi Kurio ◽  
Jae Man Lee ◽  
Takahiro Kusakabe ◽  
Hiroshi Iida
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Specific Cell ◽  
Homophilic Interaction ◽  
Adhesion Site

scholarly journals The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes

2021 ◽  
Author(s):  
Alex Moore ◽  
Kavitha Chinnaiya ◽  
Dong Won Kim ◽  
Sarah Brown ◽  
Iain Stewart ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Metabolic Phenotype ◽  
Specific Cell ◽  
Loss Of Function ◽  
Thyroid Hormone Metabolism ◽  
Neural Cell Adhesion ◽  
Stem And Progenitor Cells

Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expressed in adult mouse tanycytes. Immunohistochemical and in situ hybridization analysis revealed that NrCAM loss of function leads to both a reduced number of tanycytes and reduced expression of tanycyte-specific cell markers, along with a small reduction in tyrosine hydroxylase-positive arcuate neurons. Similar analyses of NrCAM mutants at E16 identify few changes in gene expression or cell composition, indicating that NrCAM regulates tanycytes, rather than early embryonic hypothalamic development. Neurosphere and organotypic assays support the idea that NrCAM governs cellular homeostasis. Single-cell RNA sequencing (scRNA-Seq) shows that tanycyte-specific genes, including a number that are implicated in thyroid hormone metabolism, show reduced expression in the mutant mouse. However, the mild tanycyte depletion and loss of markers observed in NrCAM-deficient mice were associated with only a subtle metabolic phenotype.

scholarly journals Cell Adhesion Molecules—Update

1997 ◽  
Vol 34 (1) ◽  
pp. 61-73 ◽  
Author(s):  
C. S. Elangbam ◽  
C. W. Qualls ◽  
R. R. Dahlgren
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecules ◽  
Cell Adhesion Molecule ◽  
Immunoglobulin Superfamily ◽  
Specific Cell ◽  
Leukocyte Function ◽  
Cell Adhesion Molecule 1 ◽  
Integrin Family

Cell adhesion molecules are glycoproteins expressed on the cell surface and play an important role in inflammatory as well as neoplastic diseases. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. The integrin family has eight subfamilies, designated as β1, through β8. The most widely studied subfamilies are β1 (CD29, very late activation [VLA] members), β2 (leukocyte integrins such as CDlla/CD18, CDllb/CD18, CDllc/CD18, and αdβ2), β3 (CD61, eytoadhesions), and β7 (α4β7 and αEβ7). The immunoglobulin superfamily includes leukocyte function antigen-2 (LFA-2 or CD2), leukocyte function antigen-3 (LFA-3 or CD58), intercellular adhesion molecules (ICAMs), vascular adhesion molecule-1 (VCAM-1), platelet-endothelial cell adhesion molecule-1 (PE-CAM-1), and mucosal addressin cell adhesion molecule-1 (MAdCAM-1). The selectin family includes E-selectin (CD62E), P-selectin (CD62P), and L-selectin (CD62L). Cadherins are major cell-cell adhesion molecules and include epithelial (E), placental (P), and neural (N) subclasses. The binding sites (ligands/receptors) are different for each of these cell adhesion molecules (e.g., ICAM binds to CD11/CD18; VCAM-1 binds to VLA-4). The specific cell adhesion molecules and their ligands that may be involved in pathologic conditions and potential therapeutie strategies by modulating the expression of these molecules will be discussed.

scholarly journals Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting.

1990 ◽  
Vol 110 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
T Elkins ◽  
M Hortsch ◽  
A J Bieber ◽  
P M Snow ◽  
C S Goodman
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Sorting ◽  
Cell Adhesion Molecule ◽  
Neuronal Development ◽  
Specific Cell ◽  
Drosophila S2 Cells ◽  
Mediate Cell ◽  
Homophilic Adhesion

Fasciclin I is a membrane-associated glycoprotein that is regionally expressed on a subset of fasciculating axons during neuronal development in insects; it is expressed on apposing cell surfaces, suggesting a role in specific cell adhesion. In this paper we show that Drosophila fasciclin I is a novel homophilic cell adhesion molecule. When the nonadhesive Drosophila S2 cells are transfected with the fasciclin I cDNA, they form aggregates that are blocked by antisera against fasciclin I. When cells expressing fasciclin I are mixed with cells expressing fasciclin III, another Drosophila homophilic adhesion molecule, the mixture sorts into aggregates homogeneous for either fasciclin I- or fasciclin III-expressing cells. The ability of these two novel adhesion molecules to mediate cell sorting in vitro suggests that they might play a similar role during neuronal development.

scholarly journals Periodate oxidation of sea urchin hyalin(s): A glycobiological study towards understanding of hyalin's function as a specific cell adhesion molecule

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Haike Ghazarian ◽  
Virginia Hutchins‐Carroll ◽  
Catherine Coyle‐Thompson ◽  
Stan Metzenberg ◽  
Ziba Razinia ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Sea Urchin ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Periodate Oxidation ◽  
Specific Cell
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