Noise characteristics and analytical precision of a direct injection high efficiency and micro concentric nebuliser for sample introduction in inductively coupled plasma mass spectrometry

2002 ◽  
Vol 17 (10) ◽  
pp. 1257-1263 ◽  
Author(s):  
Erik Björn ◽  
Tobias Jonsson ◽  
Daniel Goitom
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
High Efficiency ◽  
Direct Injection ◽  
Sample Introduction ◽  
Inductively Coupled ◽  
Analytical Precision ◽  
Noise Characteristics ◽  
Plasma Mass Spectrometry

Determination of Memory-Prone Elements Using Direct Injection High Efficiency Nebulizer Inductively Coupled Plasma Mass Spectrometry

2002 ◽  
Vol 56 (8) ◽  
pp. 1006-1012 ◽  
Author(s):  
Su-Ann E. O'Brien ◽  
John A. McLean ◽  
Billy W. Acon ◽  
Barbara J. Eshelman ◽  
William F. Bauer ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
High Efficiency ◽  
Direct Injection ◽  
Dead Volume ◽  
Spray Chamber ◽  
Inductively Coupled ◽  
Freeze Dried ◽  
Plasma Mass Spectrometry

A direct injection high efficiency nebulizer (DIHEN) and a large-bore DIHEN (LB-DIHEN) are investigated for the determination of difficult-to-analyze and memory-prone elements (mercury, iodine, and boron). The determination of such elements is problematic using conventional sample introduction systems incorporating spray chambers and/or desolvation devices owing to their large surface area and hence long wash-out characteristics. With the DIHEN or LB-DIHEN, the spray chamber is eliminated and the dead volume is reduced to <10 μL, thus reducing memory effects. In comparison with the crossflow-spray chamber combination, wash-in and wash-out times are reduced to less than 10 s when a DIHEN or LB-DIHEN is used for mercury, iodine, and boron at a concentration of 100 ng/mL. The accuracy of the DIHEN-ICPMS (inductively coupled plasma mass spectrometry) technique is evaluated in the analysis of the National Institute of Standards and Technology standard reference material (NIST SRM) 2670 (Toxic Metals in Freeze-Dried Urine) and NIST SRM 8414 (Bovine Muscle Powder). Further, the effectiveness of the DIHEN-ICPMS technique is examined in the determination of mercury and iodine in an alternative remedy medicine (seahorse genital tonic pills) and boron in rodent liver samples as part of a pharmacokinetic screening study for boron neutron capture therapy.

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