Simultaneous determination of proteins using an element-tagged immunoassay coupled with ICP-MS detection

2002 ◽  
Vol 17 (8) ◽  
pp. 892-896 ◽  
Author(s):  
Zo?? A. Quinn ◽  
Vladimir I. Baranov ◽  
Scott D. Tanner ◽  
Jeff L. Wrana
Keyword(s):  
Simultaneous Determination ◽  
Ms Detection ◽  
Icp Ms

Simultaneous Determination of Cr(III) and Cr(VI) in Ground and Drinking Waters by IC-ICP-MS

1999 ◽  
Vol 74 (1-4) ◽  
pp. 191-201 ◽  
Author(s):  
Frank Sacher ◽  
Brigitte Raue ◽  
Josef Klinger ◽  
Heinz-Jürgen Brauch
Keyword(s):  
Simultaneous Determination ◽  
Drinking Waters ◽  
Icp Ms

scholarly journals Development of a method for the simultaneous detection of Cr(iii) and Cr(vi) in exhaled breath condensate samples using μLC-ICP-MS

2016 ◽  
Vol 31 (4) ◽  
pp. 924-933 ◽  
Author(s):  
Elizabeth Leese ◽  
Jackie Morton ◽  
Philip H. E. Gardiner ◽  
Vikki A. Carolan
Keyword(s):  
Simultaneous Determination ◽  
Method Development ◽  
Exhaled Breath Condensate ◽  
Simultaneous Detection ◽  
Exhaled Breath ◽  
Development Study ◽  
Icp Ms ◽  
Breath Condensate

A method development study describing the first simultaneous determination of Cr(III) and Cr(VI) in an exhaled breath condensate sample.

Determination of alkylated tin compounds in landfill leachates using isotopically enriched tin species with GC-ICP-MS detection

2007 ◽  
Vol 22 (3) ◽  
pp. 258-266 ◽  
Author(s):  
P. Pinel-Raffaitin ◽  
P. Rodríguez-González ◽  
M. Ponthieu ◽  
D. Amouroux ◽  
I. Le Hecho ◽  
...  
Keyword(s):  
Landfill Leachates ◽  
Tin Compounds ◽  
Ms Detection ◽  
Icp Ms

Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS

2019 ◽  
Vol 411 (15) ◽  
pp. 3361-3372 ◽  
Author(s):  
Yingyi Zhang ◽  
Liang Li ◽  
Qi Wang ◽  
Mei Shen ◽  
Weili Han ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Hepatic Injury ◽  
Icp Ms

scholarly journals Simultaneous Determination of α-Fetoprotein and Free β-Human Chorionic Gonadotropin by Element-Tagged Immunoassay with Detection by Inductively Coupled Plasma Mass Spectrometry

2004 ◽  
Vol 50 (7) ◽  
pp. 1214-1221 ◽  
Author(s):  
Sichun Zhang ◽  
Chao Zhang ◽  
Zhi Xing ◽  
Xinrong Zhang
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibodies ◽  
Simultaneous Determination ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract Background: An inductively coupled plasma mass spectrometry (ICP-MS)-based immunoassay has been proposed independently by Baranov et al. (Anal Chem 2002;74:1629–36) and our group, but the applicability of this method for multianalyte analysis in clinical samples has not been fully illustrated. We developed a dual-label immunoassay method for the simultaneous determination of α-fetoprotein (AFP) and free β-human chorionic gonadotropin (hCGβ) in human serum. Methods: Monoclonal antibodies immobilized on microtiter plates captured AFP and hCGβ, which were detected by use of Eu3+-labeled anti-AFP and Sm3+-labeled anti-hCGβ monoclonal antibodies. Eu3+ and Sm3+ were dissociated from the immunocomplex with HNO3 solution (10 mL/L) and delivered by peristaltic pump to the ICP mass spectrometer. Results: The measurable ranges of AFP and hCGβ were 4.6–500 and 5.0–170 μg/L, respectively, with detection limits of 1.2 and 1.7 μg/L (3 SD above mean of zero calibrator), respectively. The intraassay imprecision (CV) for AFP was 8.3%, 4.0%, and 2.7% at 16.3, 86, and 354 μg/L, respectively, and the interassay CV was 10%, 5.7%, and 3.5%. For hCGβ, the intraassay CV was 5.4%, 6.4%, and 3.1%, respectively, at 10.5, 45.2, and 105 μg/L, and the interassay CV was 7.2%, 8.0%, and 3.7%. Comparison with IRMAs for AFP and hCGβ yielded correlation coefficients (r2) of 0.97 and 0.95. Conclusions: Two proteins can be measured simultaneously by immunoassays using two rare earth elemental tags (Eu3+ and Sm3+) and ICP-MS detection. The multielement capability and the multiple potential elemental labels make ICP-MS attractive for multianalyte immunoassays. Implementation of ICP-MS-linked immunoassays may be relatively straightforward because the labeling and immunoreaction procedures have been well developed for clinical time-resolved immunofluorometric assays.

Simultaneous Determination of Trace Elements and Lead Isotopes in Fused Silicate Rock Powders Using a Boron Nitride Vessel and fsLA-(MC)-ICP-MS

2016 ◽  
Vol 31 (4) ◽  
pp. 1012-1022 ◽  
Author(s):  
Bao Zhian ◽  
Yuan Honglin ◽  
Zong Chunlei ◽  
Liu Ye ◽  
Chen Kaiyun ◽  
...  
Keyword(s):  
Trace Elements ◽  
Boron Nitride ◽  
Simultaneous Determination ◽  
Lead Isotopes ◽  
Silicate Rock ◽  
Rock Samples ◽  
Glass Making ◽  
Icp Ms

A new glass-making method was developed to allow the in situ analysis of trace elements and lead isotopes in rock samples.

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