One pot synthesis of nitrogen-containing polycyclic δ-lactones by double nucleophilic addition of bis(trimethylsilyl)ketene acetals to pyridinesAll new compounds described in this paper were fully characterized by 200 and 400 MHz 1H NMR, 50 or 100 MHz 13C NMR, mass spectrometry and/or elemental analyses.

2002 ◽  
pp. 940-941 ◽  
Author(s):  
Henri Rudler ◽  
Bernard Denise ◽  
Andrée Parlier ◽  
Jean-Claude Daran
Keyword(s):  
Mass Spectrometry ◽  
1H Nmr ◽  
13C Nmr ◽  
Nucleophilic Addition ◽  
One Pot ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
Ketene Acetals ◽  
New Compounds

scholarly journals One pot synthesis of Biginelli 3,4-dihydro-1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines

2020 ◽  
Vol 55 (3) ◽  
pp. 173-180
Author(s):  
Md E Halim ◽  
K Akhter ◽  
SM Ahmed ◽  
Md Al Amin Hossain ◽  
UKR Romman
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Ethyl Acetoacetate ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
One Pot ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
Cyclocondensation Reaction ◽  
Anhydrous Zncl2

A simple and practical route for the Biginelli cyclocondensation reaction using anhydrous ZnCl2 as a catalyst in n-heptane-toluene medium by reaction of substituted benzaldehydes,1a-d (1a=2-ClC6H4-, 1b=2-BrC6H4- and 1c=4-ClC6H4-,1d=2-H3CC6H4-) with 1, 3-dicarbonyl compounds, 2a-b (2a= ethyl acetoacetate and 2b= acetylacetone) and urea or thiourea, 3a-b to give the corresponding Biginelli 3,4-dihydro- 1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines, 4a-d. The structures of the compounds 4a-d were confirmed by their ultraviolet, infrared, 1H NMR, 13C NMR spectra and elemental analyses. Bangladesh J. Sci. Ind. Res.55(3), 173-180, 2020

5-Aminouracil as a Building Block in Heterocyclic Synthesis, Part II. One-pot Synthesis of Pyrido[3,2-d:6,5-dʹ]dipyrimidines under Microwave Irradiation without Catalyst

2009 ◽  
Vol 64 (10) ◽  
pp. 1193-1198 ◽  
Author(s):  
Raafat M. Shaker ◽  
Mohamed A. Ameen ◽  
Afaf M. Abdel Hameed ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Irradiation ◽  
1H Nmr ◽  
13C Nmr ◽  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Elemental Analyses

An efficient and direct procedure for the synthesis of pyrido[3,2-d:6,5-dʹ]dipyrimidine derivatives under microwave-assisted conditions is been described. The structures of the products were characterized by elemental analyses, and their IR, 1H NMR, 13C NMR, and MS spectra.

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Biological Screening ◽  
Elemental Analyses ◽  
Characterization Studies

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

One pot synthesis of 2- amino-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro- 4Hchromenes- 3-carboxilic acid ethyl esters

2018 ◽  
Vol 53 (1) ◽  
pp. 35-40
Author(s):  
Al Mahmud ◽  
ME Halim ◽  
MK Ali ◽  
MA Kabir ◽  
K Akhter ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Mass Spectra ◽  
Sodium Ethoxide ◽  
Ethyl Esters ◽  
One Pot ◽  
One Pot Synthesis

Ethyl esters of 2-cyano-3-arylacrylic acid 1a-b ( a = 3- Br- C6H4, b= 4- OH- C6H4 ) reacted with 5, 5-dimethyl-1, 3-cyclohexane (2b, R = CH3) and 1c-d (c= 3- OH- C6H4, d= 3- NO2- C6H4 ) reacted with 1, 3-cyclohexanedione (2a, R = H) and 5, 5-dimethyl-1, 3-cyclohexanedione (2b, R=CH3) in the presence of alcoholic sodium ethoxide to give the corresponding ethyl esters of 2- amino- 7, 7- dimethyl-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro- 4H- chromenes-3-carboxylic acid 3a-c, 3f and 2- amino-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro- 4H- chromenes-3-carboxilic acid ethyl esters 3d-e. The structures of the compounds 3a-f were confirmed by their ultraviolet (UV), infrared (IR), 1H NMR, 13C NMR, mass spectra and elemental analyses.Bangladesh J. Sci. Ind. Res.53(1), 35-40, 2018

scholarly journals PHENOXATHIIN CHEMISTRY. NEW CARBONYL COMPOUNDS AND DERIVATIVES

1998 ◽  
Vol 6 (7) ◽  
pp. 47-57
Author(s):  
Anca Nicolae ◽  
Daniela Gavriliu ◽  
Ovidiu Maior
Keyword(s):  
13C Nmr ◽  
Spectral Methods ◽  
Carbonyl Compounds ◽  
One Pot ◽  
One Pot Synthesis ◽  
Kornblum Reaction ◽  
New Compounds ◽  
Sodium Acetylacetonate

Starting with 2-acetylphenoxathiin , 2-ω-bromoacetylphenoxathiinyl-10, 10-dioxide 2 was obtained. By means of the Kornblum reaction the corresponding glyoxal 4 was synthesized. From compound 2, the aminothiazole 3 and the 1,4-diketone 7 were also obtained. By the reaction of 2-ω-bromoacetylphenoxathiin 8 and sodium acetylacetonate "one-pot" synthesis of 1,4-diketone 9 was performed. Compound 9 was converted to pyrrolophenoxathiin 11 and 1,4-diketone 7. Starting with the brominated derivative 8 the aminoketones 12 and 13 were obtained. The new compounds were characterized by spectral methods CH-and 13C-NMR, IR, MS).

scholarly journals An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles

2011 ◽  
Vol 76 (6) ◽  
pp. 823-830 ◽  
Author(s):  
Dipti Dodiya ◽  
Haresh Ram ◽  
Amit Trivedi ◽  
Viresh Shah
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Microwave Assisted Synthesis ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Antifungal Activities ◽  
Microwave Assisted ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient, microwave-assisted synthesis of novel 2-alkoxy- 5,6,7,8-tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

scholarly journals Synthesis, Characterization and Antimicrobial Screening of Some Organotin Complexes Derived from Salicyl Hydrazide Schiff Bases

2021 ◽  
Vol 33 (12) ◽  
pp. 2977-2981
Author(s):  
Priyanka ◽  
Hardeep Singh Tuli ◽  
Pallvi Aggarwal ◽  
Manoj Kumar
Keyword(s):  
Mass Spectrometry ◽  
Schiff Bases ◽  
1H Nmr ◽  
13C Nmr ◽  
Methyl Salicylate ◽  
Therapeutic Potential ◽  
Dehydroacetic Acid ◽  
Elemental Analyses ◽  
119Sn Nmr ◽  
Ft Ir

A series of new organotin(IV) compounds [Me2SnL], [Et2SnL], [Bu2SnL] and [Ph2SnL], where L = 2-hydroxy-N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene)benzohydrazide has been synthesized by refluxing methyl salicylate hydrazide hydrate with dehydroacetic acid (DHA) with the corresponding organotin(IV) chlorides. All the compounds were characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR, 119Sn NMR and mass spectrometry. The synthesized complexes found to have wide therapeutic potential.

Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

2017 ◽  
Vol 68 (10) ◽  
pp. 2436-2439
Author(s):  
Stefania Felicia Barbuceanu ◽  
Laura Ileana Socea ◽  
Constantin Draghici ◽  
Elena Mihaela Pahontu ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Spectral Characterization ◽  
Basic Medium ◽  
Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

Synthesis of Highly Functionalized Quinazoline-2,4(1H,3H)-diones from Isocyanides, Aniline and Isocyanate via Cu-Catalyzed Intermolecular C-H Activation Reactions

2020 ◽  
Vol 17 (11) ◽  
pp. 832-836
Author(s):  
Manijeh Nematpour ◽  
Hossein Fasihi Dastjerdi ◽  
Mehdi Jahani ◽  
Sayyed Abbas Tabatabai
Keyword(s):  
13C Nmr ◽  
Reaction Times ◽  
High Yield ◽  
One Pot ◽  
1H And 13C Nmr ◽  
Activation Reaction ◽  
Elemental Analyses

A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials- catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically (1H- and 13C-NMR, IR and EI-MS) and by elemental analyses.

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