Fragmentation studies on lasalocid acid by accurate mass electrospray mass spectrometry

The Analyst ◽  
2002 ◽  
Vol 127 (9) ◽  
pp. 1224-1227 ◽  
Author(s):  
Norberto P. Lopes ◽  
Paul J. Gates ◽  
John P. G. Wilkins ◽  
James Staunton
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Accurate Mass

ACCURATE MASS ANALYSIS OF PHOSPHORAMIDITES BY ELECTROSPRAY MASS SPECTROMETRY

2005 ◽  
Vol 24 (5-7) ◽  
pp. 663-666 ◽  
Author(s):  
Z. Kupihár ◽  
Z. Timár ◽  
D. J. Dellinger ◽  
M. H. Caruthers
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Accurate Mass ◽  
Mass Analysis ◽  
Accurate Mass Analysis

Analysis of Squalene and Its Transformation By-Products in Latent Fingermarks by Ultrahigh-Pressure Liquid Chromatography-High Resolution Accurate Mass Orbitrap™ Mass Spectrometry

2019 ◽  
Author(s):  
Buddhika Dorakumbura ◽  
Francesco Busetti ◽  
Simon Lewis
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Resolution ◽  
Storage Conditions ◽  
Ultrahigh Pressure ◽  
Accurate Mass ◽  
Rational Approach ◽  
By Products ◽  
Over Time ◽  
High Resolution Accurate Mass

<p>Transformation of squalene and its by-products in fingermarks over time under different storage conditions (light, dark and underwater) was examined through ultrahigh-pressure liquid chromatography high resolution accurate mass Orbitrap™ mass spectrometry. Complications of assessing fingermark compositional variation over time using multiple samples with varying initial compositions were elucidated and a more rational approach was successfully demonstrated. Squalene was detected in all fresh natural fingermarks and the amount ranged between 0.20 to 11.32 μg/5 fingertips. A notable difference in the transformation of squalene was observed with different storage conditions, where a dark aquatic environment accelerated degradation of squalene compared to dark but dry conditions. Squalene monohydroperoxide was extremely short-lived in natural deposits while the amount of squalene epoxide was still increasing relative to the initial amount, after ageing under dark and aquatic conditions for up to 7 days. Some oxidation by-products of cholesterol were also tentatively identified, which exhibited a growth over time against their initial concentration under any of the storage condition tested. These by-products, therefore, show potential as biomarkers for targeted visualisation of aged deposits.</p>

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