Investigations into the reaction of the lithium enolate of cyclohexanone and phenyl vinyl sulfoxide: A simple synthesis of a bicyclo[4.2.0]octan-1-ol

Journal of the Chemical Society Perkin Transactions 2 ◽

10.1039/b107705h ◽

2001 ◽

pp. 296-302 ◽

Cited By ~ 5

Author(s):

Wendy A. Loughlin ◽

Catherine C. Rowen ◽

Peter C. Healy

Keyword(s):

Simple Synthesis ◽

Lithium Enolate ◽

Phenyl Vinyl

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ChemInform Abstract: Novel Formation of Isomeric Bicyclo(3.2.0)heptan-1-ols from Phenyl Vinyl Sulfoxide and the Cyclopentanone Lithium Enolate Generated by Conjugate Addition of Lithiated E-But-2-enyldiphenylphosphine Oxide to 2-Methylcyclopent-2-enone.

ChemInform ◽

10.1002/chin.199208260 ◽

2010 ◽

Vol 23 (8) ◽

pp. no-no

Author(s):

R. K. HAYNES ◽

W. A. LOUGHLIN ◽

T. W. HAMBLEY

Keyword(s):

Conjugate Addition ◽

Lithium Enolate ◽

Phenyl Vinyl

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Novel formation of isomeric bicyclo[3.2.0]heptan-1-ols from phenyl vinyl sulfoxide and the cyclopentanone lithium enolate generated by conjugate addition of lithiated (E)-but-2-enyldiphenylphosphine oxide to 2-methylcyclopent-2-enone

The Journal of Organic Chemistry ◽

10.1021/jo00020a018 ◽

1991 ◽

Vol 56 (20) ◽

pp. 5785-5790 ◽

Cited By ~ 23

Author(s):

Richard K. Haynes ◽

Wendy A. Loughlin ◽

Trevor W. Hambley

Keyword(s):

Conjugate Addition ◽

Lithium Enolate ◽

Phenyl Vinyl

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The Diels-Alder Reaction of 2-Ethenyl-1,4-Benzodioxin: A New and Simple Synthesis of Bisaryl Ethers

Synlett ◽

10.1055/s-1989-20343 ◽

1989 ◽

Vol 1989 (01) ◽

pp. 30-32

Author(s):

Thomas V. Lee ◽

Alistair J. Leigh ◽

Christopher B. Chapleo

Keyword(s):

Alder Reaction ◽

Diels Alder ◽

Simple Synthesis ◽

Diels Alder Reaction

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Targeted Delivery of Cabazitaxel by Conjugation to Albumin-PEG-folate Nanoparticles Using a Cysteine-acrylate Linker and Simple Synthesis Conditions

Current Drug Delivery ◽

10.2174/1567201814666161122150302 ◽

2017 ◽

Vol 14 (8) ◽

Cited By ~ 5

Author(s):

Mohammad Kazem Khoeeniha ◽

Mehdi Esfandyari-Manesh ◽

Hossein Behrouz ◽

Mohsen Amini ◽

Behrang Shiri Varnamkhasti ◽

...

Keyword(s):

Targeted Delivery ◽

Simple Synthesis ◽

Synthesis Conditions

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A Simple Synthesis of the Anticancer Drug Altretamine

Letters in Organic Chemistry ◽

10.2174/1570178617666200210111041 ◽

2020 ◽

Vol 17 (8) ◽

pp. 628-630

Author(s):

Vu Binh Duong ◽

Pham Van Hien ◽

Tran Thai Ngoc ◽

Phan Dinh Chau ◽

Tran Khac Vu

Keyword(s):

Aqueous Solution ◽

Anticancer Drug ◽

Potassium Hydroxide ◽

Large Scale ◽

Synthesis Method ◽

Practical Method ◽

Cyanuric Chloride ◽

Simple Synthesis ◽

High Yield ◽

One Step

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

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