Synthesis, X-ray structure and molecular modelling analysis of cobalt(ii), nickel(ii), zinc(ii) and cadmium(ii) complexes of the widely used anti-inflammatory drug meloxicam

2002 ◽  
pp. 1888 ◽  
Author(s):  
Sandra Defazio ◽  
Renzo Cini
Keyword(s):  
Molecular Modelling ◽  
Inflammatory Drug ◽  
X Ray ◽  
Modelling Analysis ◽  
Anti Inflammatory

Speciation study of the anti-inflammatory drug tenoxicam (Htenox) with Cu(II): X-ray crystal structure of [Cu(tenox)2(py)2]·EtOH

2003 ◽  
Vol 95 (2-3) ◽  
pp. 131-140 ◽  
Author(s):  
M.R. Moya-Hernández ◽  
A. Mederos ◽  
S. Domı́nguez ◽  
A. Orlandini ◽  
C.A. Ghilardi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Inflammatory Drug ◽  
X Ray ◽  
Speciation Study ◽  
Anti Inflammatory

scholarly journals Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2140
Author(s):  
Francisco Javier Acebedo-Martínez ◽  
Carolina Alarcón-Payer ◽  
Antonio Frontera ◽  
Rafael Barbas ◽  
Rafel Prohens ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Solid State ◽  
Pharmaceutical Industry ◽  
Thermal Analyses ◽  
Active Pharmaceutical Ingredient ◽  
Niflumic Acid ◽  
X Ray Diffraction ◽  
Inflammatory Drug ◽  
X Ray ◽  
Anti Inflammatory

Any time the pharmaceutical industry develops a new drug, potential polymorphic events must be thoroughly described, because in a crystalline pharmaceutical solid, different arrangements of the same active pharmaceutical ingredient can yield to very different physicochemical properties that might be crucial for its efficacy, such as dissolution, solubility, or stability. Polymorphism in cocrystal formulation cannot be neglected, either. In this work, two different cocrystal polymorphs of the non-steroidal anti-inflammatory drug niflumic acid and caffeine are reported. They have been synthesized by mechanochemical methods and thoroughly characterized in solid-state by powder and single crystal X-ray diffraction respectively, as well as other techniques such as thermal analyses, infrared spectroscopy and computational methods. Both theoretical and experimental results are in agreement, confirming a conformational polymorphism. The polymorph NIF–CAF Form I exhibits improved solubility and dissolution rate compared to NIF–CAF Form II, although Form II is significantly more stable than Form I. The conditions needed to obtain these polymorphs and their transition have been carefully characterized, revealing an intricate system.

1167-P: Safety and Efficacy of 52 Weeks' Therapy with Hydroxychloroquine (HCQ)—First Anti-inflammatory Drug Approved in India for T2D

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1167-P
Author(s):  
ANIL PAREEK ◽  
RAVI TEJRAJ MEHTA ◽  
SHRUTI DHARMADHIKARI ◽  
KUMAR BHASKAR NAIDU
Keyword(s):  
Safety And Efficacy ◽  
Inflammatory Drug ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document