Highly selective one-pot conversion of THP and MOM ethers to acetates by indium triiodide-catalysed deprotection and subsequent transesterification by ethyl acetate

2001 ◽  
pp. 2262-2265 ◽  
Author(s):  
Brindaban C. Ranu ◽  
Alakananda Hajra
Keyword(s):  
Ethyl Acetate ◽  
One Pot

Ethyl Acetate as a Pro-Reducing Agent in an One-Pot Reductive Deamination of Nitroanilines

2004 ◽  
Vol 77 (5) ◽  
pp. 1027-1028 ◽  
Author(s):  
Valeriy A. Bacherikov ◽  
May-Jane Wang ◽  
Shu-Yun Cheng ◽  
Ching-Huang Chen ◽  
Kuo-Tung Chen ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Reducing Agent ◽  
One Pot

Kinetic modeling of lipase-mediated one-pot chemo-bio cascade synthesis ofR-1-phenyl ethyl acetate starting from acetophenone

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Serap Sahin ◽  
Johan Wärnå ◽  
Päivi Mäki-Arvela ◽  
Tapio Salmi ◽  
Dmitry Yu. Murzin
Keyword(s):  
Ethyl Acetate ◽  
Kinetic Modeling ◽  
One Pot

Practical Synthesis of 2'-5'-Linked Oligoadenylates (2-5A Oligomers)

1992 ◽  
Vol 45 (1) ◽  
pp. 205 ◽  
Author(s):  
R Noyori ◽  
M Uchiyama ◽  
T Nobori ◽  
M Hirose ◽  
Y Hayakawa
Keyword(s):  
Ethyl Acetate ◽  
Second Order ◽  
High Yield ◽  
Similar Reaction ◽  
Reaction Sequence ◽  
Facile Synthesis ◽  
One Pot ◽  
Subsequent Oxidation ◽  
Practical Synthesis ◽  
Related Compounds

A general, facile synthesis of 2'-5'-linked oligonucleotides (2-5A oligomers ) has been achieved based on the second-order regioselective protection of adenosine, one-pot formation of the 2'5' internucleotide linkage, and O-selective phosphorylation of N-unblocked nucleosides. Standard t- butyldimethylsilylation of 5'-O-p-methoxytrityladenosine followed by careful recrystallization from a mixture of triethylamine , methanol, ethyl acetate and ether (4 : 4 : 5 : 100 v/v) gives the 3',5'-di-O-protected adenosine in high yield. Magnesium alkoxide -mediated condensation of the 2'-O-free adenosine with o-chlorophenyl p-nitrophenyl phosphorochloridate followed by 2',3'-di-O-t-butyldimethylsilyladenosine produces the N-free and fully O-protected adenylyl (2'-5')adenosine. The resulting adenylyl dimer, after removal of the 5'-O-trityl protector, is elongated to the protected trimeric compound through a similar reaction sequence. Deprotection of the product furnishes the 2-5A core. Condensation of the 5?-0-detritylated core and bis (2,2,2-trichloroethyl) phosphorochloridite assisted by 2,6-lutidine and subsequent oxidation with aqueous iodine produces, after deblocking, 2-5A 5'-monophosphate (p5'A2'p5'pA2'p5'A). The 2-5A 5'-monophosphate is converted into 2-5A 5'-triphosphate (ppp5'A2'p5'A2'p5'A) by reaction with N,N'-carbonyldiimidazole in the presence of triethylamine followed by tributylammonium diphosphate. This procedure allows ready synthesis of 2-5A oligomers and related compounds on a multigram scale.

scholarly journals Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing Ball Mill Technique: Green Sustainable Process

2017 ◽  
Author(s):  
Ameen Shahid ◽  
Nesreen S. Ahmed ◽  
Tamer S. Saleh ◽  
Shaeel A. Al-Thabaiti ◽  
Sulaiman N. Basahel ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ball Mill ◽  
Zeolite Catalyst ◽  
High Yield ◽  
One Pot ◽  
Hierarchical Zeolite ◽  
Three Component Reaction ◽  
High Yields ◽  
Biginelli Reactions ◽  
Short Time

A sustainable green one pot procedure for the synthesis of dihydropyrimidinones (DHPMs) derivatives by a three-component reaction of β-ketoester derivatives, aldehyde and urea or thiourea over the alkali-treated H-ZSM-5 zeolite under ball-milling has been developed. The product was isolated by simple washing of the crude reaction residue with ethyl acetate followed by evaporation of solvent. The hierachical zeolite catalyst (MFI27_6) showed high yield (86–96%) of dihydropyrimidinones (DHPMs), in very short time (10-30 min). The catalyst is recycled for subsequent reactions in four runs without appreciable loss of activity and high yields of products provide efficient protocol for Biginelli reactions.

scholarly journals Chemicals from ethanol – The dehydrogenative route of the ethyl acetate one-pot synthesis

2011 ◽  
Vol 334 (1-2) ◽  
pp. 29-34 ◽  
Author(s):  
Priscila C. Zonetti ◽  
Johnatan Celnik ◽  
Sonia Letichevsky ◽  
Alexandre B. Gaspar ◽  
Lucia G. Appel
Keyword(s):  
Ethyl Acetate ◽  
One Pot ◽  
One Pot Synthesis

A one-pot method for the synthesis of 3-(hetero-)aryl-1,4,2-dioxazol-5-ones

2020 ◽  
Vol 98 (3) ◽  
pp. 158-163 ◽  
Author(s):  
Toren Hynes ◽  
David S. Hall ◽  
Alexander W.H. Speed ◽  
Jason D. Masuda ◽  
J.R. Dahn
Keyword(s):  
Ethyl Acetate ◽  
Lithium Ion Batteries ◽  
Hydroxamic Acid ◽  
Room Temperature ◽  
Lithium Ion ◽  
Environmentally Benign ◽  
One Pot ◽  
Electrolyte Additives ◽  
Reaction Proceeds ◽  
Halogenated Solvents

3-R-1,4,2-dioxazol-5-ones are a class of compounds that are increasingly finding diverse uses, including as regioselective amidation reagents and as electrolyte additives that enable long cycling lifetimes in rechargeable lithium-ion batteries. Conventional methods for their synthesis tend to be slow and time-consuming, requiring isolation and thorough drying of a hydroxamic acid intermediate, followed by a separate cyclization step with N,N′-carbonyldiimidazole. Furthermore, the cyclization is typically performed in dichloromethane, an environmentally harmful solvent. This work demonstrates a new one-pot method for the synthesis of these compounds that eliminates the need for isolation of the intermediate or the use of halogenated solvents. The reaction is mainly performed using environmentally benign ethyl acetate and a relatively small amount of N,N-dimethylformamide. The reaction proceeds readily at room temperature and requires no expensive metal catalysts to function.

scholarly journals Cyclopropanation of Terminal Alkenes via Sequential Atom Transfer Radical Addition – 1,3-Elimination

2019 ◽  
Author(s):  
Nicholas D. C. Tappin ◽  
Weronika Michalska ◽  
Simon Rohrbach ◽  
Philippe Renaud
Keyword(s):  
Ethyl Acetate ◽  
Radical Addition ◽  
Atom Transfer ◽  
Reaction Sequence ◽  
One Pot ◽  
Tetrabutylammonium Fluoride ◽  
Wide Range ◽  
Atom Transfer Radical Addition ◽  
Simple Protocol ◽  
Terminal Alkenes

An operationally simple protocol to affect an atom transfer radical addition (ATRA) of commercially available ICH<sub>2</sub>Bpin to terminal alkenes has been developed. The intermediate iodide can be transformed in a one-pot process into the corresponding cyclopropane upon treatment with tetrabutylammonium fluoride (TBAF). This method is highly selective for the cyclopropanation of unactivated terminal alkenes over non-terminal alkenes and electron deficient alkenes. Due to the mildness of the procedure, a wide range of functional groups such as esters, amides, alcohols, ketones, and vinylic cyclopropanes are well tolerated. The whole reaction sequence relies on simple reagents such dilauroyl peroxide (DLP) and TBAF and can be run on multi-gram scales in ethyl acetate as a solvent.

Environmentally benign PEG-OSO3H catalysed Ultrasound promoted cascade synthesis of furocoumarins in water

2020 ◽  
Vol 07 ◽  
Author(s):  
Devendra S. Wagare ◽  
Mujahed Shaikh ◽  
Lingampalle D.L. ◽  
Ayesha Durrani
Keyword(s):  
Ethyl Acetate ◽  
Reaction Medium ◽  
Reusable Catalyst ◽  
One Pot ◽  
Reduced Pressure ◽  
Aromatic Ketones ◽  
One Pot Synthesis ◽  
Aqueous Layer ◽  
The One

Background: Green synthesis of furocoumarins in water, PEG-OSO3H used as a recyclable catalyst for the one-pot syntheis in water. avoid used of toxic, lachrymatric and unstablephenacyl bromides instead of that we prepared it in-situ and directly condence with 4-hydroxycoumarins. Objective: PEG-OSO3H found to be an efficient and reusable catalyst for the microwave irradiated one-pot synthesis of 3- Aryl-furo[3,2-c]coumarins in PEG-water as a greener reaction medium. This method found to be rapid, simple, ecofriendly and yield obtained relatively higher than other reported methods. Methods: Aromatic ketones (5 mmol), NBS (5mmol) was added in solution of PEG-OSO3H (10 mol%) in 10 ml water and irradiated under ultrasound at 80-85°C. then solution of 4-hydroxycoumarin (5 mmol) and solution of acetic acid and ammonium acetate (1 ml) were added into it. Reaction mass was further irradiated for 3 min. The reaction mixture was extracted with ethyl acetate (3 x 10ml) and the combined ethyl acetate phase was concentrated under reduced pressure to obtain corresponding 3-Aryl-furo[3,2-c]coumarins. Aqueous layer was reused for the next reactions. Results: It was observed that electrons withdrawing groups (-NO2,-F etc.) on benzene ring of aromatic ketones increases the rate of reactions as well as yield of the products. The IR spectrum of compound 4a showed prominent peaks at 1737cm-1C=O stretching for lactone, 1H NMR of compound 4c showed characteristic singlets for –CH3 of methoxy group of at 3.94 ppm, The above spectral data confirmed the structure of compound. The 13C NMR spectrum of 4b also shows the peaks of CH3, at 23.25 ppm. Conclusion: PEG-OSO3H found to be an efficient and reusable catalyst for the microwave irradiated one-pot synthesis of 3-Aryl-furo[3,2-c]coumarins in PEG-water as a greener reaction medium. This method found to be rapid, simple, ecofriendly and yield obtained relatively higher than other reported methods.

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