Optimization of the technique of standard additions for inductively coupled plasma mass spectrometry

2001 ◽  
Vol 16 (5) ◽  
pp. 464-469 ◽  
Author(s):  
Paul Abbyad ◽  
John Tromp ◽  
Joseph Lam ◽  
Eric Salin
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Standard Additions

scholarly journals Determination of Lead in Botanicals/Chinese Prepared Medicines by Using Microwave Digestion with Flow Injection–Inductively Coupled Plasma–Mass Spectrometry

2000 ◽  
Vol 83 (2) ◽  
pp. 382-390 ◽  
Author(s):  
Eng-Shi Ong ◽  
Yuk-Lin Yong ◽  
Soo-On Woo
Keyword(s):  
Mass Spectrometry ◽  
Flow Injection ◽  
Inductively Coupled Plasma ◽  
Microwave Digestion ◽  
Matrix Interference ◽  
Inductively Coupled ◽  
Relative Standard ◽  
Plasma Mass Spectrometry ◽  
Standard Additions

Abstract A simple, sensitive, and rapid method was developed for the determination of lead in botanicals and Chinese prepared medicines (CPM) by using closed-vessel microwave digestion with flow injection–inductively coupled plasma–mass spectrometry. The limits of detection and quantitation for the method, based on 0.5 g digested sample, were calculated to be 0.10 and 0.61 mg/kg, respectively. A simple approach was proposed for calibration by multiple linear regression (MLR) with 207Pb, 206Pb, and 204Pb for the determination of lead in botanical and CPM samples. The results from calibration by MLR were compared with those obtained by conventional modes using 207Pb and the sum of 207Pb and 206Pb. The results obtained by the different modes of calibration were in good agreement for botanical and CPM samples. The method was found to have good accuracy for the analysis of botanical reference materials. Method precision based on analyses of different types of CPM samples by different analysts on different days for different levels of lead was between 3.0 and 8.0% (relative standard deviation, n = 6). The effect of possible matrix interference caused by nitric acid and the extent of digestion was investigated with the method of standard additions. Significant matrix interference was not observed for the CPM samples analyzed. MLR was used to examine the effect of variation in isotopic abundance, which was found to present no significant problem in the determination of lead in the botanical and CPM samples.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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