Gadolinium DO3A derivatives mimicking phospholipids; preparation and in vitro evaluation as pH responsive MRI contrast agents

2001 ◽  
pp. 929-933 ◽  
Author(s):  
Ragnar Hovland ◽  
Christian Gløgård ◽  
Arne J. Aasen ◽  
Jo Klaveness
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Ph Responsive ◽  
Mri Contrast ◽  
In Vitro Evaluation

Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc

2011 ◽  
Vol 17 (5) ◽  
pp. 1529-1537 ◽  
Author(s):  
Anurag Mishra ◽  
Nikos K. Logothetis ◽  
David Parker
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
In Vitro Evaluation

scholarly journals Study on Establishing Reference Safe Concentrations of MRI Contrast Agents for Optimized Images: Paramagnetic Gd-DTPA-BMEA and Superparamagnetic Ferucarbotran

2021 ◽  
Vol 11 (3) ◽  
pp. 1165
Author(s):  
Wen-Tien Hsiao ◽  
Yi-Hong Chou ◽  
Jhong-Wei Tu ◽  
Ai-Yih Wang ◽  
Lu-Han Lai
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
In Vitro Experiments ◽  
Mri Contrast ◽  
In Vivo Experiments ◽  
Contrast Agent Injection

The purpose of this study is to establish the minimal injection doses of magnetic resonance imaging (MRI) contrast agents that can achieve optimized images while improving the safety of injectable MRI drugs. Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) and ferucarbotran, commonly used in clinical practice, were selected and evaluated with in vitro and in vivo experiments. MRI was acquired using T1-weighted (T1W) and T2-weighted (T2W) sequences, and the results were quantitatively analyzed. For in vitro experiments, results showed that T1W and T2W images were optimal when Gd-DTPA-bisamide (2-oxoethyl) (Gd-DTPA-BMEA) and ferucarbotran were diluted to a volume percentage of 0.6% and 0.05%; all comparisons were significant differences in grayscale statistics using one-way analysis of variance (ANOVA). For in vivo experiments, the contrast agent with optimal concentration percentages determined from in vitro experiments were injected into mice with an injection volume of 100 μL, and the images of brain, heart, liver, and mesentery before and after injection were compared. The statistical results showed that the p values of both T1W and T2W were less than 0.001, which were statistically significant. Under safety considerations for MRI contrast agent injection, optimized MRI images could still be obtained after reducing the injection concentration, which can provide a reference for the safety concentrations of MRI contrast agent injection in the future.

Water-soluble magnetic CoO nanocrystals functionalized with surfactants as T2-weighed MRI contrast agents in vitro

2011 ◽  
Vol 40 (14) ◽  
pp. 3616 ◽  
Author(s):  
Hong Yang ◽  
Hong Zhou ◽  
Cuixia Zhang ◽  
Xuejian Li ◽  
He Hu ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast

Water-Soluble Gadofullerenes:  Toward High-Relaxivity, pH-Responsive MRI Contrast Agents

2005 ◽  
Vol 127 (2) ◽  
pp. 799-805 ◽  
Author(s):  
Éva Tóth ◽  
Robert D. Bolskar ◽  
Alain Borel ◽  
Gabriel González ◽  
Lothar Helm ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mri Contrast ◽  
High Relaxivity

scholarly journals Magneto-Liposomes as MRI Contrast Agents: A Systematic Study of Different Liposomal Formulations

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 889 ◽  
Author(s):  
Nina Kostevšek ◽  
Calvin C. L. Cheung ◽  
Igor Serša ◽  
Mateja Erdani Kreft ◽  
Ilaria Monaco ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Lipid Bilayer ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Liposomal Formulations ◽  
Icp Ms ◽  
Magnetic Resonance Imaging Mri ◽  
Cancerous Cells ◽  
Selection Of

The majority of the clinically approved iron oxide nanoparticles (IO NPs) used as contrast agents for magnetic resonance imaging (MRI) have been withdrawn from the market either due to safety concerns or lack of profits. To address this challenge, liposomes have been used to prepare IO-based T2 contrast agents. We studied the influence of different phospholipids on the relaxivity (r2) values of magneto-liposomes (MLs) containing magnetic NPs in the bilayer, where a strong correlation between the bilayer fluidity and r2 is clearly shown. Embedding 5-nm IO NPs in the lipid bilayer leads to a significant improvement in their relaxivity, where r2 values range from 153 ± 5 s−1 mM−1 for DPPC/cholesterol/DSPE-PEG (96/50/4) up to 673 ± 12 s−1 mM−1 for DOPC/DSPE-PEG (96/4), compared to “free” IO NPs with an r2 value of 16 s−1 mM−1, measured at 9.4 T MRI scanner. In vitro MRI measurements, together with the ICP-MS analysis, revealed MLs as highly selective contrast agents that were preferentially taken up by cancerous T24 cells, which led to an improvement in the contrast and an easier distinction between the healthy and the cancerous cells. A careful selection of the lipid bilayer to prepare MLs could offer efficient MRI contrast agents, even at very low IO NP concentrations.

pH-sensitive paramagnetic liposomes as MRI contrast agents: in vitro feasibility studies

2001 ◽  
Vol 19 (5) ◽  
pp. 731-738 ◽  
Author(s):  
Knut-Egil Løkling ◽  
Sigrid L Fossheim ◽  
Roald Skurtveit ◽  
Atle Bjørnerud ◽  
Jo Klaveness
Keyword(s):  
Contrast Agents ◽  
Feasibility Studies ◽  
Mri Contrast Agents ◽  
Ph Sensitive ◽  
Mri Contrast

Paramagnetic liposomes as MRI contrast agents: influence of liposomal physicochemical properties on the in vitro relaxivity

1999 ◽  
Vol 17 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Sigrid L. Fossheim ◽  
Anne Kjersti Fahlvik ◽  
Jo Klaveness ◽  
Robert N. Muller
Keyword(s):  
Physicochemical Properties ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Multiwalled carbon nanotube hybrids as MRI contrast agents

2016 ◽  
Vol 7 ◽  
pp. 1086-1103 ◽  
Author(s):  
Nikodem Kuźnik ◽  
Mateusz Michał Tomczyk
Keyword(s):  
Carbon Nanotubes ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Molecular Probes ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Tissue Imaging ◽  
Multiwalled Carbon ◽  
Mri Contrast

Magnetic resonance imaging (MRI) is one of the most commonly used tomography techniques in medical diagnosis due to the non-invasive character, the high spatial resolution and the possibility of soft tissue imaging. Contrast agents, such as gadolinium complexes and superparamagnetic iron oxides, are administered to spotlight certain organs and their pathologies. Many new models have been proposed that reduce side effects and required doses of these already clinically approved contrast agents. These new candidates often possess additional functionalities, e.g., the possibility of bioactivation upon action of particular stimuli, thus serving as smart molecular probes, or the coupling with therapeutic agents and therefore combining both a diagnostic and therapeutic role. Nanomaterials have been found to be an excellent scaffold for contrast agents, among which carbon nanotubes offer vast possibilities. The morphology of multiwalled carbon nanotubes (MWCNTs), their magnetic and electronic properties, the possibility of different functionalization and the potential to penetrate cell membranes result in a unique and very attractive candidate for a new MRI contrast agent. In this review we describe the different issues connected with MWCNT hybrids designed for MRI contrast agents, i.e., their synthesis and magnetic and dispersion properties, as well as both in vitro and in vivo behavior, which is important for diagnostic purposes. An introduction to MRI contrast agent theory is elaborated here in order to point to the specific expectations regarding nanomaterials. Finally, we propose a promising, general model of MWCNTs as MRI contrast agent candidates based on the studies presented here and supported by appropriate theories.

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