The biosynthesis of plant alkaloids and nitrogenous microbial metabolitesThis review and those that preceded it are dedicated to my three teachers who were each a marvellous scientific inspiration: F. G. Holliman, A. R. Battersby and G. Stork. They were the giants onto whose shoulders I was privileged to climb.

2003 ◽  
Vol 20 (5) ◽  
pp. 494 ◽  
Author(s):  
Richard B. Herbert
Keyword(s):  
Plant Alkaloids ◽  
Scientific Inspiration

Effect of Some Metabolic Inhibitors on Vinblastine-Induced Ribosomal-Granular Material Complexes

1971 ◽  
Vol 29 ◽  
pp. 548-549
Author(s):  
Awtar Krishan ◽  
Dora Hsu
Keyword(s):  
Granular Material ◽  
Rna Synthesis ◽  
Culture Medium ◽  
Actinomycin D ◽  
Metabolic Inhibitors ◽  
Protein And Rna Synthesis ◽  
Apparent Reduction ◽  
Plant Alkaloids ◽  
In Cells

Cells exposed to antitumor plant alkaloids, vinblastine and vincristine sulfate have large proteinacious crystals and complexes of ribosomes, helical polyribosomes and electron-dense granular material (ribosomal complexes) in their cytoplasm, Binding of H3-colchicine by the in vivo crystals shows that they contain microtubular proteins. Association of ribosomal complexes with the crystals suggests that these structures may be interrelated.In the present study cultured human leukemic lymphoblasts (CCRF-CEM), were incubated with protein and RNA-synthesis inhibitors, p. fluorophenylalanine, puromycin, cycloheximide or actinomycin-D before the addition of crystal-inducing doses of vinblastine to the culture medium. None of these compounds could completely prevent the formation of the ribosomal complexes or the crystals. However, in cells pre-incubated with puromycin, cycloheximide, or actinomycin-D, a reduction in the number and size of the ribosomal complexes was seen. Large helical polyribosomes were absent in the ribosomal complexes of cells treated with puromycin, while in cells exposed to cycloheximide, there was an apparent reduction in the number of ribosomes associated with the ribosomal complexes (Fig. 2).

scholarly journals Self-assembly of Quaternary Benzo[c]phenanthridine Plant Alkaloids into Dimer in Aqueous Solution

2021 ◽  
pp. 116014
Author(s):  
Zsombor Miskolczy ◽  
Mónika Megyesi ◽  
György Lendvay ◽  
László Biczók
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Plant Alkaloids

scholarly journals Potential of plant alkaloids as dengue ns3 protease inhibitors: Molecular docking and simulation approach

2014 ◽  
Vol 9 (3) ◽  
Author(s):  
Muhammad Tahir Ul Qamar ◽  
Arooj Mumtaz ◽  
Usman Ali Ashfaq ◽  
Muhammad Muzammal Adeel ◽  
Tabeer Fatima
Keyword(s):  
Molecular Docking ◽  
Protease Inhibitors ◽  
Simulation Approach ◽  
Ns3 Protease Inhibitors ◽  
Plant Alkaloids ◽  
Ns3 Protease

Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis

2000 ◽  
Vol 409 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Laurent Dassonneville ◽  
Amélie Lansiaux ◽  
Aurélie Wattelet ◽  
Nicole Wattez ◽  
Christine Mahieu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Drug Induced ◽  
Plant Alkaloids ◽  
Induced Apoptosis

Plant Alkaloids of the Polymethyleneamine Series

ChemInform ◽  
2005 ◽  
Vol 36 (40) ◽  
Author(s):  
L. N. Rogoza ◽  
N. F. Salakhutdinov ◽  
G. A. Tolstikov
Keyword(s):  
Plant Alkaloids

The toxicity of plant alkaloids: an Ecogeographic perspective

1978 ◽  
Vol 6 (1) ◽  
pp. 61-76 ◽  
Author(s):  
Donald A. Levin ◽  
Billie M. York
Keyword(s):  
Plant Alkaloids

Plant Alkaloids

Chemotherapy ◽  
1977 ◽  
pp. 379-425 ◽  
Author(s):  
William A. Creasey
Keyword(s):  
Plant Alkaloids

scholarly journals Nephrotoxicity and Chinese Herbal Medicine

2018 ◽  
Vol 13 (10) ◽  
pp. 1605-1611 ◽  
Author(s):  
Bo Yang ◽  
Yun Xie ◽  
Maojuan Guo ◽  
Mitchell H. Rosner ◽  
Hongtao Yang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Aristolochic Acid ◽  
Herbal Medicines ◽  
Kidney Injury ◽  
Medicine Use ◽  
Chinese Herbal ◽  
Aristolochic Acids ◽  
Increase Risk ◽  
Plant Alkaloids

Chinese herbal medicine has been practiced for the prevention, treatment, and cure of diseases for thousands of years. Herbal medicine involves the use of natural compounds, which have relatively complex active ingredients with varying degrees of side effects. Some of these herbal medicines are known to cause nephrotoxicity, which can be overlooked by physicians and patients due to the belief that herbal medications are innocuous. Some of the nephrotoxic components from herbs are aristolochic acids and other plant alkaloids. In addition, anthraquinones, flavonoids, and glycosides from herbs also are known to cause kidney toxicity. The kidney manifestations of nephrotoxicity associated with herbal medicine include acute kidney injury, CKD, nephrolithiasis, rhabdomyolysis, Fanconi syndrome, and urothelial carcinoma. Several factors contribute to the nephrotoxicity of herbal medicines, including the intrinsic toxicity of herbs, incorrect processing or storage, adulteration, contamination by heavy metals, incorrect dosing, and interactions between herbal medicines and medications. The exact incidence of kidney injury due to nephrotoxic herbal medicine is not known. However, clinicians should consider herbal medicine use in patients with unexplained AKI or progressive CKD. In addition, exposure to herbal medicine containing aristolochic acid may increase risk for future uroepithelial cancers, and patients require appropriate postexposure screening.

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