Triazacyclohexane complexes of chromium as highly active homogeneous model systems for the Phillips catalyst

2000 ◽  
pp. 1927-1928 ◽  
Author(s):  
Randolf D. Köhn ◽  
Matthias Haufe ◽  
Shahram Mihan ◽  
Dieter Lilge
Keyword(s):  
Homogeneous Model ◽  
Model Systems ◽  
Phillips Catalyst ◽  
Highly Active

1,3,5-Triazacyclohexane Complexes of Chromium as Homogeneous Model Systems for the Phillips Catalyst

2003 ◽  
pp. 88-100 ◽  
Author(s):  
Randolf D. Köhn ◽  
D. Smith ◽  
D. Lilge ◽  
S. Mihan ◽  
F. Molnar ◽  
...  
Keyword(s):  
Homogeneous Model ◽  
Model Systems ◽  
Phillips Catalyst

1,3,5-Triazacyclohexane Complexes of Chromium as Homogeneous Model Systems for the Phillips Catalyst

2001 ◽  
pp. 147-155 ◽  
Author(s):  
Randolf D. Köhn ◽  
Guido Seifert ◽  
Gabriele Kociok-Köhn ◽  
Shahram Mihan ◽  
Dieter Lilge ◽  
...  
Keyword(s):  
Homogeneous Model ◽  
Model Systems ◽  
Phillips Catalyst

scholarly journals Nearsightedness of Finite Homogeneous Model Systems

2015 ◽  
Author(s):  
Yuki Mitsuta ◽  
Shusuke Yamanaka ◽  
Takashi Kawakami ◽  
Mitsutaka Okumura ◽  
Kizashi Yamaguchi ◽  
...  
Keyword(s):  
Homogeneous Model ◽  
Model Systems

A Chromium Catalyst for the Polymerization of Ethylene as a Homogeneous Model for the Phillips Catalyst

2005 ◽  
Vol 127 (4) ◽  
pp. 1082-1083 ◽  
Author(s):  
Leonard A. MacAdams ◽  
Gerald P. Buffone ◽  
Christopher D. Incarvito ◽  
Arnold L. Rheingold ◽  
Klaus H. Theopold
Keyword(s):  
Homogeneous Model ◽  
Phillips Catalyst ◽  
Chromium Catalyst

Anti-Factor IX Antibodies Displaying FVIIIa-Like Activity.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1713-1713
Author(s):  
Randolf J. Kerschbaumer ◽  
Michael Dockal ◽  
Rosing Jan ◽  
Fritz Scheiflinger
Keyword(s):  
Active Form ◽  
Factor Ix ◽  
Model Systems ◽  
Factor X ◽  
Fviii Inhibitor ◽  
Highly Active ◽  
Factor Viiia ◽  
New Strategy ◽  
Active Protease ◽  
Key Events

Abstract One of the key events during hemostasis is the conversion of the zymogen factor X (FX) into its enzymatically active form FXa by the protease factor IXa (FIXa). FIXa assembles on a phospholipid surface together with its cofactor factor VIIIa (FVIIIa) which transforms FIXa from a very poor enzyme into a highly active protease. In order to mimic the stimulating effect of coagulation FVIIIa on FIXa, we identified a series of antibodies specific for FIX that exhibit FVIII-like activity. Upon binding to human FIXa these antibodies increased the turnover number (kcat) of FIXa-catalysed FX activation approximately 10-fold. Procoagulant activity of these anti-FIXa antibodies could be detected in model systems containing purified proteins as well as in FVIII-depleted plasma and FVIII-inhibitor plasma. In plasma-assays contact activators and tissue factor were applied as a trigger, and the antibodies were effective in both cases. Our findings demonstrate that FVIII can be at least partially replaced by an antibody which might open up a new strategy for improving the treatment of hemophilia.

scholarly journals Model systems in heterogeneous catalysis: towards the design and understanding of structure and electronic properties

2018 ◽  
Vol 208 ◽  
pp. 307-323 ◽  
Author(s):  
Q. Pan ◽  
L. Li ◽  
S. Shaikhutdinov ◽  
Y. Fujimori ◽  
M. Hollerer ◽  
...  
Keyword(s):  
Ethylene Polymerization ◽  
Model System ◽  
The Other ◽  
Model Systems ◽  
Nano Particles ◽  
Nano Particle ◽  
Additional Information ◽  
Phillips Catalyst ◽  
Catalyst Systems ◽  
Au Nano Particles

We discuss in this paper two case studies related to nano-particle catalyst systems: one concerns a model system for the Cr/SiO2 Phillips catalyst for ethylene polymerization and the other provides additional information on Au nano-particles supported on ultrathin MgO(100)/Ag(100) films.

Nuclear coiled bodies and the nucleolus

1994 ◽  
Vol 52 ◽  
pp. 20-21
Author(s):  
K. Brasch ◽  
J. Williams ◽  
D. Gallo ◽  
T. Lee ◽  
R. L. Ochs
Keyword(s):  
Mouse Liver ◽  
Nuclear Body ◽  
Nuclear Bodies ◽  
Model Systems ◽  
Coiled Body ◽  
Rrna Processing ◽  
Malignant Cells ◽  
Sm Proteins ◽  
Coiled Bodies ◽  
Unique Protein

Though first described in 1903 by Ramon-y-Cajal as silver-staining “accessory bodies” to nucleoli, nuclear bodies were subsequently rediscovered by electron microscopy about 30 years ago. Nuclear bodies are ubiquitous, but seem most abundant in hyperactive and malignant cells. The best studied type of nuclear body is the coiled body (CB), so termed due to characteristic morphology and content of a unique protein, p80-coilin (Fig.1). While no specific functions have as yet been assigned to CBs, they contain spliceosome snRNAs and proteins, and also the nucleolar protein fibrillarin. In addition, there is mounting evidence that CBs arise from or are generated near the nucleolus and then migrate into the nucleoplasm. This suggests that as yet undefined links may exist, between nucleolar pre-rRNA processing events and the spliceosome-associated Sm proteins in CBs.We are examining CB and nucleolar changes in three diverse model systems: (1) estrogen stimulated chick liver, (2) normal and neoplastic cells, and (3) polyploid mouse liver.

Microtubule Dynamics and Organelle Transport in Reticulomyxa

1990 ◽  
Vol 48 (3) ◽  
pp. 194-195
Author(s):  
Yih-Tai Chen ◽  
Ursula Euteneuer ◽  
Ken B. Johnson ◽  
Michael P. Koonce ◽  
Manfred Schliwa
Keyword(s):  
Plasma Membrane ◽  
Light Microscopy ◽  
Cytoplasmic Dynein ◽  
Living Cells ◽  
Microtubule Dynamics ◽  
Model Systems ◽  
Organelle Transport ◽  
Biochemical Characteristics ◽  
Dependent Transport

The application of video techniques to light microscopy and the development of motility assays in reactivated or reconstituted model systems rapidly advanced our understanding of the mechanism of organelle transport and microtubule dynamics in living cells. Two microtubule-based motors have been identified that are good candidates for motors that drive organelle transport: kinesin, a plus end-directed motor, and cytoplasmic dynein, which is minus end-directed. However, the evidence that they do in fact function as organelle motors is still indirect.We are studying microtubule-dependent transport and dynamics in the giant amoeba, Reticulomyxa. This cell extends filamentous strands backed by an extensive array of microtubules along which organelles move bidirectionally at up to 20 μm/sec (Fig. 1). Following removal of the plasma membrane with a mild detergent, organelle transport can be reactivated by the addition of ATP (1). The physiological, pharmacological and biochemical characteristics show the motor to be a cytoplasmic form of dynein (2).

Microstructural observations of the “Wustite-Spinel” coexistence following quenching of cation-excess spinels, Ni2(1+x)Ti1-xO4

1990 ◽  
Vol 48 (4) ◽  
pp. 1058-1059
Author(s):  
Ian M. Anderson ◽  
Arnulf Muan ◽  
C. Barry Carter
Keyword(s):  
Film Growth ◽  
Spinel Phase ◽  
Model Systems ◽  
Ion Milling ◽  
Coexistence Of Phases ◽  
Nonequilibrium Conditions ◽  
Diffraction Patterns ◽  
Spinel Structures ◽  
Highly Porous ◽  
Standard Techniques

Oxide mixtures which feature a coexistence of phases with the wüstite and spinel structures are considered model systems for the study of solid-state reaction kinetics, phase boundaries, and thin-film growth, and such systems are especially suited to TEM studies. (In this paper, the terms “wüstite” and “spinel” will refer to phases of those structure types.) The study of wüstite-spinel coexistence has been limited mostly to systems near their equilibrium condition, where the assumptions of local thermodynamic equilibrium are valid. The cation-excess spinels of the type Ni2(1+x)Ti1-xO4, which reportedly exist only above 1375°C4, provide an excellent system for the study of wüstite-spinel coexistence under highly nonequilibrium conditions. The nature of these compounds has been debated in the literature. X-ray and neutron powder diffraction patterns have been used to advocate the existence of a single-phase, non- stoichiometric spinel. TEM studies of the microstructure have been used to suggest equilibrium coexistence of a stoichiometric spinel, Ni2TiO4, and a wüstite phase; this latter study has shown a coexistence of wüstite and spinel phases in specimens thought to have been composed of a single, non- stoichiometric spinel phase. The microstructure and nature of this phase coexistence is the focus of this study. Specimens were prepared by ball-milling a mixture of NiO and TiO2 powders with 10 wt.% TiO2. The mixture was fired in air at 1483°C for 5 days, and then quenched to room temperature. The aggregate thus produced was highly porous, and needed to be infiltrated prior to TEM sample preparation, which was performed using the standard techniques of lapping, dimpling, and ion milling.

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