Intramolecular carbometalation of functionalized terminal alkynes via low-valent titanium complexes

2000 ◽  
pp. 1849-1850 ◽  
Author(s):  
Natalia Morlender-Vais ◽  
Nicka Solodovnikova ◽  
Ilan Marek
Keyword(s):  
Terminal Alkynes ◽  
Titanium Complexes ◽  
Low Valent

ChemInform Abstract: Intramolecular Carbometalation of Functionalized Terminal Alkynes via Low-Valent Titanium Complexes.

ChemInform ◽  
2001 ◽  
Vol 32 (1) ◽  
pp. no-no
Author(s):  
Natalia Morlender-Vais ◽  
Nicka Solodovnikova ◽  
Ilan Marek
Keyword(s):  
Terminal Alkynes ◽  
Titanium Complexes ◽  
Low Valent

scholarly journals Low-Valent Pentafulvene Titanium Dinitrogen Complex as a Precursor for Cationic Titanium Complexes

2009 ◽  
Vol 28 (24) ◽  
pp. 6969-6974 ◽  
Author(s):  
Axel Scherer ◽  
Detlev Haase ◽  
Wolfgang Saak ◽  
Rüdiger Beckhaus ◽  
Auke Meetsma ◽  
...  
Keyword(s):  
Titanium Complexes ◽  
Low Valent ◽  
Dinitrogen Complex

Highly regioselective [2+2+2] cycloaddition of terminal alkynes catalyzed by titanium complexes of p-tert-butylthiacalix[4]arene

2006 ◽  
Vol 47 (7) ◽  
pp. 1157-1161 ◽  
Author(s):  
Naoya Morohashi ◽  
Katsuya Yokomakura ◽  
Tetsutaro Hattori ◽  
Sotaro Miyano
Keyword(s):  
Terminal Alkynes ◽  
Titanium Complexes

Redox chemistry of discrete low-valent titanium complexes and low-valent titanium synthons

2021 ◽  
Vol 57 (80) ◽  
pp. 10292-10316
Author(s):  
Skye Fortier ◽  
Alejandra Gomez-Torres
Keyword(s):  
Redox Chemistry ◽  
Titanium Complexes ◽  
Feature Article ◽  
Low Valent

The redox chemistry of well-defined low-valent titanium complexes and low-valent titanium synthons is reviewed in this feature article.

Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4-Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

2020 ◽  
Vol 16 ◽  
Author(s):  
Lucas da Silva Santos ◽  
Matheus Fillipe Langanke de Carvalho ◽  
Ana Claudia de Souza Pinto ◽  
Amanda Luisa da Fonseca ◽  
Julio César Dias Lopes ◽  
...  
Keyword(s):  
Triazole Ring ◽  
Antiplasmodial Activity ◽  
World Health ◽  
Dipolar Cycloaddition ◽  
Terminal Alkynes ◽  
The World ◽  
Ic50 Values ◽  
Derivatives Of ◽  
Active Substances

Background: Malaria greatly affects the world health, having caused more than 228 million cases only in 2018. The emergence of drug resistance is one of the main problems in its treatment, demonstrating the urge for the development of new antimalarial drugs. Objective: Synthesis and in vitro antiplasmodial evaluation of triazole compounds derived from isocoumarins and a 3,4- dihydroisocoumarin. Method: The compounds were synthesized in 4 to 6-step reactions with the formation of the triazole ring via the Copper(I)-catalyzed 1,3-dipolar cycloaddition between isocoumarin or 3,4-dihydroisocoumarin azides and terminal alkynes. This key reaction provided compounds with an unprecedented connection of isocoumarin or 3,4-dihydroisocoumarin and the 1,2,3-triazole ring. The products were tested for their antiplasmodial activity against a Plasmodium falciparum chloroquine resistant and sensitive strains (W2 and 3D7, respectively). Results: Thirty-one substances were efficiently obtained by the proposed routes with an overall yield of 25-53%. The active substances in the antiplasmodial test displayed IC50 values ranging from 0.68-2.89 μM and 0.85-2.07 μM against W2 and 3D7 strains, respectively.

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