Artifactual chemiluminescence in the determination of nitrogen monoxide in the vapour phase of mainstream cigarette smoke

The Analyst ◽  
1989 ◽  
Vol 114 (1) ◽  
pp. 71 ◽  
Author(s):  
Peter R. Houlgate ◽  
William H. Evans
Keyword(s):  
Cigarette Smoke ◽  
Nitrogen Monoxide ◽  
Vapour Phase ◽  
Mainstream Cigarette Smoke

scholarly journals Evaluation of an online, real-time, soft-photon ionisation time-of-flight mass spectrometer for mainstream tobacco smoke analysis

BMC Chemistry ◽  
2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Jenni Hawke ◽  
Graham Errington ◽  
Matthias Bente von Frowein
Keyword(s):  
Real Time ◽  
Cigarette Smoke ◽  
Mass Spectrometer ◽  
Relative Error ◽  
Tobacco Smoke ◽  
Time Of Flight ◽  
Vapour Phase ◽  
Time Of Day ◽  
Flight Mass Spectrometer ◽  
Mainstream Cigarette Smoke

AbstractMainstream tobacco smoke is a complex and dynamic aerosol, consisting of particulate and vapour phases. Most approaches to determine mainstream smoke toxicant yields are based on offline techniques that limit the opportunity to observe in real time the processes leading to smoke formation. The recent development of online real-time analytical methods offers many advantages over traditional techniques. Here we report the LM2X-TOFMS (Borgwaldt GmbH, Germany), a commercial instrument that couples a linear smoking engine with a time-of-flight mass spectrometer for real-time per-puff measurement of the vapour phase of mainstream cigarette smoke. Total cigarette and puff-by-puff (μg/puff) yields were evaluated, in line with International Council of Harmonisation recommendations, for seven smoke toxicants: acetaldehyde, acetone, 1,3-butadiene, 2-butanone, benzene, isoprene and toluene. Measurements were unaffected by small system changes including replacing the sampling capillary or time of day (all P > 0.05), indicating that the LM2X-TOFMS is rugged. Control charts showed that the system has good stability and control. Analysis of certified gas mixtures of six concentrations of each analyte showed a highly linear response for all seven analytes (R2 = 0.9922–0.9999). In terms of repeatability, the lowest variation was observed for isoprene with a coefficient of variation (CV) of < 6% for each concentration. Acetaldehyde showed the highest CV, increasing from 8.0 to 26.6% with decreasing gas concentration. Accuracy was analysed in terms of relative error, which was ± 16% for six of the analytes; however, the relative error for acetaldehyde was (− 36.2%), probably due to its low ionisation efficiency under the instrument’s vacuum ultraviolet lamp. Three cigarette products (reference and commercial) with different ISO tar levels were analysed by the LM2X-TOFMS puff by puff under ISO regulatory smoking conditions. The relative standard deviation based on average yield per cigarette for each analyte in each product (summed puffs per product, n = 30) ranged from ≤ 9.3 to ≤ 16.2%. Measurements were consistent with published data per cigarette. In conclusion, the LM2X-TOFMS is suitable for determining the vapour-phase yields of seven analytes on a real-time, puff-by-puff basis, and can be utilised for both fast screening (qualitative) and quantitative measurements of mainstream cigarette smoke.

An UPLC-MS3 Method for Rapid Separation and Determination of Four Tobacco-specific Nitrosamines in Mainstream Cigarette Smoke

2011 ◽  
Vol 58 (5) ◽  
pp. 667-672 ◽  
Author(s):  
Yu Ding ◽  
Jun Yang ◽  
Wen-Jing Zhu ◽  
Cheng-Hui Wang ◽  
Dong-Liang Zhu ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Rapid Separation ◽  
Tobacco Specific Nitrosamines ◽  
Mainstream Cigarette Smoke
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