Potentiometric titration method for the simultaneous determination of two monofunctional weak acids of similar strength: titration to the initial potential

The Analyst ◽  
1983 ◽  
Vol 108 (1285) ◽  
pp. 537-540
Author(s):  
Hilda Szalai ◽  
Tamás L. Pál
Keyword(s):  
Simultaneous Determination ◽  
Potentiometric Titration ◽  
Weak Acids ◽  
Titration Method ◽  
Potentiometric Titration Method

scholarly journals Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples

2018 ◽  
Vol 34 (2) ◽  
pp. 23
Author(s):  
Rogério Adelino De Sousa ◽  
Éder Tadeu Gomes Cavalheiro
Keyword(s):  
Potentiometric Titration ◽  
Confidence Level ◽  
Redox Reaction ◽  
Potentiometric Determination ◽  
Titration Method ◽  
Pharmaceutical Samples ◽  
Chromatographic Procedure ◽  
Potentiometric Titration Method

A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.

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