The determination of warfarin in animal tissues by electron-capture gas-liquid chromatography

The Analyst ◽  
1976 ◽  
Vol 101 (1203) ◽  
pp. 478 ◽  
Author(s):  
E. M. Odam ◽  
M. G. Townsend
Keyword(s):  
Liquid Chromatography ◽  
Electron Capture ◽  
Gas Liquid Chromatography ◽  
Animal Tissues

Determination of Hexachloro-1,3-butadiene in Spinach, Eggs, Fish, and Milk by Electron Capture Gas-Liquid Chromatography

1976 ◽  
Vol 59 (3) ◽  
pp. 552-558
Author(s):  
Martin P Yurawecz ◽  
Peter A Dreifuss ◽  
Laverne R Kamps
Keyword(s):  
Liquid Chromatography ◽  
Petroleum Ether ◽  
Electron Capture ◽  
Mississippi River ◽  
Waste Product ◽  
Official Method ◽  
Gas Liquid Chromatography ◽  
Lower Mississippi River ◽  
Food Commodities

Abstract Hexachloro-1,3-butadiene (HCBD), a waste product formed in the manufacture of perchloroethylene and trichloroethylene, has been found in fish from the lower Mississippi River basin. The AOAC official method for organochlorine pesticide residues in fatty and nonfatty foods has been modified for the determination of HCBD residues in selected food commodities. Acetonitrile extracts of nonfatty foods, or the combined acetonitrile extracts obtained in acetonitrile-petroleum ether partitioning of fat isolated from fatty foods, are diluted with water and extracted with petroleum ether. The petroleum ether extracts are chromatographed on Florisil and HCBD is eluted with petroleum ether. The eluate is analyzed by gas-liquid chromatography with an electron capture detector. Average recoveries of HCBD from fortified samples of fatty and nonfatty foods were greater than 90% in the interlaboratory trials of the method.

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