Colorimetric determination of antazoline in some pharmaceutical preparations with sodium nitrite

The Analyst ◽  
1974 ◽  
Vol 99 (1181) ◽  
pp. 487 ◽  
Author(s):  
M. M. Amer ◽  
M. S. Tawakkol ◽  
S. A. Ismaiel
Keyword(s):  
Sodium Nitrite ◽  
Pharmaceutical Preparations ◽  
Colorimetric Determination

Colorimetric Determination of Amoxicillin in Pure and some Pharmaceutical Formulations Via Reaction with Potassium Permanganate as Oxidant Reagent

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Abbas Shebeeb Al-kadumi ◽  
Sahar Rihan Fadhel ◽  
Mohammed Abdullah Ahmed ◽  
Luma Amer Musa
Keyword(s):  
Potassium Permanganate ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Atomic Emission ◽  
Basic Medium ◽  
Photometric Method ◽  
Colorimetric Determination ◽  
Spectrophotometric Methods ◽  
Label Claim

We proposed two simple, rapid, and convenient spectrophotometric methods are described for the determination of Amoxicillin in bulk and its pharmaceutical preparations. They are based on the measurement of the flame atomic emission of potassium ion (in first method) and colorimetric determination of the green colored solution for manganite ion at 610 nm formed after reaction of Amoxicillin with potassium permanganate as oxidant agent (in the second method) in basic medium. The working conditions of the methods were investigated and optimized. Beer's law plot showed a good correlation in the concentration range of 5-45 μg/ml. The detection limits and relative standared deviations were (2.573, 2.814 μg/ml) (2.137, 2.498) for the flame emission photometric method and (1.844, 2.016 μg/ml) (1.645,1.932) for colorimetric methods for capsules and suspensions respectively. The methods were successfully applied to the determination of Amoxicillin in capsules and suspensions, and the obtained results were in good agreement with the label claim. No interference was observed from the commonly encountered additives and expectancies.

Colorimetric Determination of Terbutaline Sulfate and Orciprenaline Sulfate via Nitrosation and Difference Spectrophotometry

1987 ◽  
Vol 70 (3) ◽  
pp. 568-571 ◽  
Author(s):  
Mohamed E El-Sadek ◽  
Hisham E Abdel Latef ◽  
Afaf A Aboul Khier
Keyword(s):  
Hydrochloric Acid ◽  
Sodium Nitrite ◽  
Colorimetric Method ◽  
Dosage Forms ◽  
Alkaline Media ◽  
Colorimetric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Terbutaline Sulfate ◽  
The Difference

Abstract A colorimetric method is proposed for determination of terbutaline sulfate, orciprenaline sulfate, and their dosage forms. The suggested method depends on nitrosation of the 2 drugs by using sodium nitrite and hydrochloric acid. Addition of sodium hydroxide increases the intensity of the color developed. The difference between absorption values measured in acid and alkaline media is taken as a measure of concentration. Variables were carefully studied and optimized. Results for both compounds adhered to Beer's law over the range 2- 28 μg/mL. The method has proved to be accurate and precise for analysis of pharmaceutical dosage forms.

Colorimetric Determination of Oxyphenisatin and Oxyphenisatin Diacetate in Pharmaceutical Preparations

1964 ◽  
Vol 47 (4) ◽  
pp. 688-692
Author(s):  
Antoine Major
Keyword(s):  
Aqueous Solution ◽  
Organic Solvent ◽  
Silver Nitrate ◽  
Sodium Hydroxide ◽  
Column Chromatography ◽  
Sodium Hydroxide Solution ◽  
Pharmaceutical Preparations ◽  
Colorimetric Determination ◽  
Hydroxide Solution

Abstract A method is described which will quantitatively determine 0.1 mg oxyphenisatin or the diacetate in various pharmaceutical preparations. After removal of interferences by organic solvent extractions from aqueous solution and partition column chromatography, the reaction of oxyphenisatin (diacetate) with silver nitrate in alcoholic sodium hydroxide solution produces a violet solution, which follows Beer’s law (1—15 μg per ml). The method was satisfactorily applied to the assay of commercial tablets, liquids, and powders with recoveries, as per cent found of declared, in the range 95—101%.

Rapid Colorimetric Assay of Trimethoprim and Sulfamethoxazole in Pharmaceuticals

1983 ◽  
Vol 66 (6) ◽  
pp. 1447-1449 ◽  
Author(s):  
Asis K Sanyal ◽  
Dinabandhu Laha
Keyword(s):  
Solvent Extraction ◽  
Colorimetric Assay ◽  
Pharmaceutical Preparations ◽  
Ion Pair ◽  
Pair Formation ◽  
Bromophenol Blue ◽  
Colorimetric Determination ◽  
Ion Pair Formation ◽  
Subsequent Measurement

Abstract A method is described for the direct colorimetric determination of trimethoprim and sulfamethoxazole in pharmaceutical preparations, without prior separation. Estimation of trimethoprim is based on its ion-pair formation with bromophenol blue and subsequent measurement of absorbance of the ionpair at 418 nm. Estimation of sulfamethoxazole is possible without removal of trimethoprim by solvent extraction.

Colorimetric Determination of Certain Phenol Derivatives in Pharmaceutical Preparations

1981 ◽  
Vol 64 (6) ◽  
pp. 1442-1445
Author(s):  
Sayed M Hassan ◽  
Mohammed I Walash ◽  
Sanaa M El-Sayed ◽  
Abdel Malek Abou Ouf
Keyword(s):  
Pharmaceutical Preparations ◽  
Sulfanilic Acid ◽  
Diazonium Salts ◽  
Colorimetric Determination ◽  
Reaction Products ◽  
Optimum Conditions ◽  
Phenol Derivatives ◽  
The Mean ◽  
Colorimetric Methods

Abstract Simple colorimetric methods are reported for determining both acetaminophen and oxyphenbutazone. These methods are based on coupling between the phenolic compound and the diazonium salts of both sulfanilic acid and p-nitroaniline; the optimum conditions for the reactions were carefully studied. For acetaminophen, the reaction products with diazosulfanilic acid and diazo-p-nitroaniline show maximum absorbance at 480 and 425 nm, respectively. The mean percentage recoveries for authentic samples were 99.5 ± 1.1 and 100.6 ± 0.66, respectively (P = 0.05). For oxyphenbutazone, the obtained colors showed maxima at 385 nm with diazosulfanilic acid and 490 nm with diazo-p-nitroaniline reactions. The mean percentage recoveries for authentic samples were 99.8 ± 0.27 and 100.1 ± 0.57, respectively (P = 0.05). The proposed methods were successfully applied to the analysis of commercial preparations; results were statistically compared with those of other methods.

Sign in / Sign up

Export Citation Format

Share Document