A selective amplification-titration procedure for the determination of microgram amounts of phosphate

The Analyst ◽  
1968 ◽  
Vol 93 (1105) ◽  
pp. 224 ◽  
Author(s):  
G. F. Kirkbright ◽  
A. M. Smith ◽  
T. S. West
Keyword(s):  
Selective Amplification ◽  
Titration Procedure

Analysis of Sodium Diphenylhydantoin and Phenobarbital Combinations by Nonaqueous Titration

1968 ◽  
Vol 51 (5) ◽  
pp. 1013-1016
Author(s):  
Sura J P Agarwal ◽  
Martin I Blake
Keyword(s):  
Exchange Resin ◽  
Cation Exchange Resin ◽  
Ammonium Hydroxide ◽  
Butyl Alcohol ◽  
Dosage Forms ◽  
Direct Titration ◽  
Titration Procedure ◽  
Tert Butyl Alcohol ◽  
Preliminary Separation

Abstract A simple, nonaqueous titration procedure is described for the determination of sodium diphenylhydantoin and phenobarbital combinations. Preliminary separation of the components is unnecessary. The phenobarbital content is determined by direct titration in tert.-butyl alcohol, using sodium methoxide or triethyl n-butyl ammonium hydroxide as the titrant. The total acidity is determined by titration of the sample after passage through a cation exchange resin (Amberlite IRC-50). The sodium diphenylhydantoin content is obtained by difference. Quantitative recoveries were obtained for synthetic mixtures and commercially available dosage forms

Determination of Intracellular Magnesium by an Automatic Titration Procedure

1960 ◽  
Vol 6 (6) ◽  
pp. 564-571 ◽  
Author(s):  
Donald A Sones ◽  
Warren F McGuckin ◽  
Khalil G Wakim
Keyword(s):  
Magnesium Concentration ◽  
Normal Range ◽  
Intracellular Magnesium ◽  
Titration Procedure ◽  
Term Administration ◽  
Original Procedure ◽  
Increase In Accuracy ◽  
Automatic Titration

Abstract Our experiences with the automatic titration method of quantitating serum calcium and magnesium are presented. In addition, modifications of the original procedure to allow determination of intraerythrocyte concentrations of magnesium are described. It appears that adoption of a separate magnesium standard in addition to the calcium standard, plus certain other minor modifications designed to minimize the variables inherent in the procedure, provides a significant increase in accuracy and reproducibility of results. Values for intraerythrocyte magnesium concentration in 9 normal dogs were found to range from 4.69 to 5.77 mg./100 ml. Values for 4 dogs that received long-term administration of chlorothiazide also fell within this normal range.

Differentiating Nonaqueous Titration of Mixtures Containing Acetaminophen and Salicylamide

1973 ◽  
Vol 56 (3) ◽  
pp. 653-655
Author(s):  
Martin I Blake ◽  
Linda B Shumaker
Keyword(s):  
Dosage Forms ◽  
Electrode System ◽  
Glass Electrode ◽  
Tetrabutylammonium Hydroxide ◽  
Titration Procedure ◽  
The Individual

Abstract A differentiating nonaqueous titration procedure is described for the determination of mixtures of acetaminophen and salicylamide. Tetrabutylammonium hydroxide is the titrant and a Fisher titrimeter equipped with a calomel-glass electrode system is used. The technique is applied to the individual components, synthetic mixtures, and complex dosage forms.

The Rapid Determination of Calcium in Biologic Material

1959 ◽  
Vol 5 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Harold D Appleton ◽  
Marcia West ◽  
Mary Mandel ◽  
Angelo M Sala
Keyword(s):  
Excellent Agreement ◽  
Rapid Determination ◽  
Rapid Procedure ◽  
End Point ◽  
Titration Procedure ◽  
Serum And Urine

Abstract A rapid procedure for the routine determination of calcium in serum and urine has been described. 0.1 ml. of serum is titrated directly with standard EDTA, using either a calcein-KCl mixture or a calcein-thymolphthalein-KCl mixture. The end point with either indicating mixture is sharp. Excellent agreement is shown with the oxalate isolation and permanganate titration procedure.

410. The oxidation of ascorbic acid in dairy products

1950 ◽  
Vol 17 (1) ◽  
pp. 54-65 ◽  
Author(s):  
J. E. Allan
Keyword(s):  
Ascorbic Acid ◽  
Cold Storage ◽  
Dairy Products ◽  
Room Temperature ◽  
Ferric Iron ◽  
Storage Temperature ◽  
Chloride Ion ◽  
Inhibitory Effect ◽  
Titration Procedure

1. The determination of ascorbic acid in butter by the usual macrotitration method was found to be impossible because this substance rapidly became oxidized while the butter was being melted, so that only about half could be recovered.2. A simple micro-titration procedure enabled more reliable results to be obtained, but the loss of ascorbic acid from smaller samples could not be reduced below about 10% under the most favourable conditions.3. Kinetic experiments have been carried out on butter serum and buttermilk to which ascorbic acid had been added, and from the results it has been deduced that the oxidation of ascorbic acid takes place by three distinct concomitant reactions: one catalysed by the original copper, one catalysed by added copper, and one catalysed by added ferric iron.4. It has been calculated that in an unsalted butter of normal metallic content half the ascorbic acid would be oxidized in about 12 hr. at cold storage temperature ( – 13° C). At this temperature, 0·1 p.p.m. of added copper is about twenty times as effective a catalyst as 1·0 p.p.m. of added iron. At room temperature the corresponding half-oxidation time would be about 2 hr., and here 0·1 p.p.m. of added copper is about four times as active as 1·0 p.p.m. of added iron. In salted butter the inhibitory effect of the chloride ion would increase these times somewhat.5. The chemical state in which copper and iron exist in milk and related products has been discussed, especially in relation to the kinetic results obtained.

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