Efficient tin hydride-mediated radical cyclisation of secondary amides leading to substituted pyrrolidinones. Part 2. Application to the synthesis of aromatic kainic acid analogues

1999 ◽  
pp. 2905-2910 ◽  
Author(s):  
Justin S. Bryans ◽  
Jonathan M. Large ◽  
Andrew F. Parsons
Keyword(s):  
Kainic Acid ◽  
Secondary Amides

Nimesulide Aggravates Kainic Acid-Induced Seizures in the Rat

2001 ◽  
Vol 88 (5) ◽  
pp. 271-276 ◽  
Author(s):  
Tina KunzNote ◽  
Ernst H. Oliw
Keyword(s):  
Kainic Acid

Influence of kainic acid and long-lasting intermitent hypoxia on auditory cortex

2005 ◽  
Vol 84 (01) ◽  
Author(s):  
P Benesová ◽  
M Langmeier ◽  
J Betka ◽  
S Trojan
Keyword(s):  
Auditory Cortex ◽  
Kainic Acid

Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex

1974 ◽  
Vol 12 (2) ◽  
pp. 141 ◽  
Author(s):  
Han Jong Rim ◽  
Joung Hwan Ha ◽  
Joon Sang Lee ◽  
Il Hyun ◽  
Kwang Bon Uh
Keyword(s):  
Kainic Acid ◽  
Mass Treatment ◽  
Acid Complex

scholarly journals Reduced Interhemispheric Coherence in Cerebellar Kainic Acid-Induced Lateralized Dystonia

2020 ◽  
Vol 11 ◽  
Author(s):  
Elena Laura Georgescu Margarint ◽  
Ioana Antoaneta Georgescu ◽  
Carmen Denise Mihaela Zahiu ◽  
Stefan-Alexandru Tirlea ◽  
Alexandru Rǎzvan Şteopoaie ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Kainic Acid ◽  
Primary Motor Cortex ◽  
Low Frequency ◽  
Muscular Activity ◽  
Cerebellar Hemisphere ◽  
Interhemispheric Coherence ◽  
General Locomotor Activity ◽  
Complex Circuits ◽  
The Right

The execution of voluntary muscular activity is controlled by the primary motor cortex, together with the cerebellum and basal ganglia. The synchronization of neural activity in the intracortical network is crucial for the regulation of movements. In certain motor diseases, such as dystonia, this synchrony can be altered in any node of the cerebello-cortical network. Questions remain about how the cerebellum influences the motor cortex and interhemispheric communication. This research aims to study the interhemispheric cortical communication between the motor cortices during dystonia, a neurological movement syndrome consisting of sustained or repetitive involuntary muscle contractions. We pharmacologically induced lateralized dystonia to adult male albino mice by administering low doses of kainic acid on the left cerebellar hemisphere. Using electrocorticography and electromyography, we investigated the power spectral densities, cortico-muscular, and interhemispheric coherence between the right and left motor cortices, before and during dystonia, for five consecutive days. Mice displayed lateralized abnormal motor signs, a reduced general locomotor activity, and a high score of dystonia. The results showed a progressive interhemispheric coherence decrease in low-frequency bands (delta, theta, beta) during the first 3 days. The cortico-muscular coherence of the affected side had a significant increase in gamma bands on days 3 and 4. In conclusion, lateralized cerebellar dysfunction during dystonia was associated with a loss of connectivity in the motor cortices, suggesting a possible cortical compensation to the initial disturbances induced by cerebellar left hemisphere kainate activation by blocking the propagation of abnormal oscillations to the healthy hemisphere. However, the cerebellum is part of several overly complex circuits, therefore other mechanisms can still be involved in this phenomenon.

scholarly journals Hydrogenation of secondary amides using phosphane oxide and frustrated Lewis pair catalysis

2021 ◽  
Author(s):  
Laura Köring ◽  
Nikolai A. Sitte ◽  
Markus Bursch ◽  
Stefan Grimme ◽  
Jan Henry Hakan Paradies
Keyword(s):  
Frustrated Lewis Pair ◽  
Secondary Amides
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