Biosynthesis of porphyrins and related macrocycles. Part 52. Synthesis of (11-S )-[11-2H1]porphobilinogen and the (11R)-enantiomer for stereochemical studies on hydroxymethylbilane synthase (porphobilinogen deaminase)

1999 ◽  
pp. 2677-2689 ◽  
Author(s):  
Werner L. Neidhart ◽  
Paul C. Anderson ◽  
Graham J. Hart ◽  
Alan R. Battersby
Keyword(s):  
Porphobilinogen Deaminase ◽  
Biosynthesis Of Porphyrins

Biosynthesis of porphyrins and corrins. 2. Isolation, purification, and NMR investigations of the porphobilinogen deaminase covalent complex

Biochemistry ◽  
1986 ◽  
Vol 25 (4) ◽  
pp. 905-912 ◽  
Author(s):  
Jeremy N. S. Evans ◽  
Gerardo Burton ◽  
Paul E. Fagerness ◽  
Neil E. Mackenzie ◽  
A. Ian Scott
Keyword(s):  
Porphobilinogen Deaminase ◽  
Covalent Complex ◽  
Biosynthesis Of Porphyrins

ChemInform Abstract: BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES. PART 12. VITAMIN B12: STUDIES WITH 1-METHYLBILANES

1979 ◽  
Vol 10 (44) ◽  
Author(s):  
A. R. BATTERSBY ◽  
S. KISHIMOTO ◽  
E. MCDONALD ◽  
F. SATOH ◽  
H. K. W. WURZIGER
Keyword(s):  
Vitamin B12 ◽  
Biosynthesis Of Porphyrins

scholarly journals PCR detection of a C/T polymorphism in exon 1 of the porphobilinogen deaminase gene (PBGD)

1991 ◽  
Vol 19 (18) ◽  
pp. 5099-5099 ◽  
Author(s):  
C. Picat ◽  
F. Bourgeois ◽  
Bemard Grandchamp
Keyword(s):  
Pcr Detection ◽  
Porphobilinogen Deaminase ◽  
Exon 1

Protoporphyrinogen oxidase, porphobilinogen deaminase and uroporphyrinogen decarboxylase in variegate porphyria

1985 ◽  
Vol 13 (1) ◽  
pp. 203-204 ◽  
Author(s):  
P. N. MEISSNER ◽  
E. D. STURROCK ◽  
M. R. MOORE ◽  
P. B. DISLER ◽  
D. L. MAEDER
Keyword(s):  
Porphobilinogen Deaminase ◽  
Uroporphyrinogen Decarboxylase ◽  
Protoporphyrinogen Oxidase ◽  
Variegate Porphyria

Biosynthesis of uroporphyrinogens from porphobilinogen: mechanism and the nature of the process

1976 ◽  
Vol 273 (924) ◽  
pp. 137-160 ◽  
Keyword(s):  
Reaction Medium ◽  
Porphobilinogen Deaminase

The enzymic self-polymerization of porphobilinogen gives rise to the cyclic tetrapyrroles uroporphyrinogen III and uroporphyrinogen I. The former is the precursor of all the natural porphyrins and chlorins. The formation of uroporphyrinogen III is catalysed by a dual enzymic system, porphobilinogen deaminase and uroporphyrinogen III cosynthase. Deaminase polymerizes four porphobilinogen units on the enzymic surface, without liberation of free intermediates into the reaction medium, and forms uroporphyrinogen I. Cosynthase enters into association with the deaminase, and acts as a ‘specifier protein' of the latter, changing the mode of porphobilinogen condensation on the enzymic surface. The association is independent of the presence of substrate. While deaminase catalyses the head-to-tail condensation of the porphobilinogen units, the association deaminase-cosynthase catalyses the head-to-head condensation of the same units. As a result different enzyme-bound dipyrrylmethanes are formed from the beginning of the process, and this can be demonstrated by using synthetic dipyrrylmethanes and tripyrranes.

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