First η1-ligated 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene complexes and the remarkable trihydration reaction of trans-[PtCl2(PMe3)(P3C3But3)] to cis-[PtCl(PMe3)(P3O3C3H5But3)], containing the novel CH(But)PH(O)C(But)PH(O)CH(But)P(O) ring system

1999 ◽  
pp. 1377-1378 ◽  
Author(s):  
Scott B. Clendenning ◽  
Peter B. Hitchcock ◽  
John F. Nixon
Keyword(s):  
Ring System ◽  
The Novel ◽  
Tert Butyl

scholarly journals Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3268
Author(s):  
Katja S. Håheim ◽  
Emil Lindbäck ◽  
Kah Ni Tan ◽  
Marte Albrigtsen ◽  
Ida T. Urdal Helgeland ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antimicrobial Activities ◽  
Ring System ◽  
Human Prostate ◽  
The Novel ◽  
Human Prostate Cancer ◽  
Biofilm Inhibition

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 µM; 9b: MBIC = 100 µM).

Synthesis and properties of the novel .eta.4-trimethylenemethane compounds [.eta.4-C(CH2)3]Fe(CO)2L (L = tertiary phosphines, tert-butyl isocyanide)

1991 ◽  
Vol 10 (9) ◽  
pp. 3114-3119 ◽  
Author(s):  
Luc. Girard ◽  
Joseph H. MacNeil ◽  
Adnan. Mansour ◽  
Antony C. Chiverton ◽  
John A. Page ◽  
...  
Keyword(s):  
The Novel ◽  
Tert Butyl ◽  
Tertiary Phosphines

Iminophosphorane-mediated synthesis of fused [1,2,4]triazines: preparation of the novel [1,2,4]triazino[4,3-b][1,2,4,5]tetrazine ring system

Tetrahedron ◽  
1988 ◽  
Vol 44 (8) ◽  
pp. 2249-2259 ◽  
Author(s):  
Pedro Molina ◽  
Mateo Alajarin ◽  
Angel Vidal ◽  
J. Elguero ◽  
R.M. Claramunt
Keyword(s):  
Ring System ◽  
The Novel

Behavior of 1,3-Di(tert-butyl)-2,4-bis(tetramethylpiperidino)-1,3,2,4-diphospha- diboretane towards Boron Halides and Adduct Formation of a Bicyclo[1.1.0]diphosphadiboretane with Tris(pentafluorophenyl)borane [1]

2006 ◽  
Vol 61 (3) ◽  
pp. 265-274 ◽  
Author(s):  
Klaus Knabel ◽  
Heinrich Nöth ◽  
Robert T. Paine
Keyword(s):  
Molecular Structure ◽  
Structure Analysis ◽  
Adduct Formation ◽  
Ring System ◽  
Lewis Acidity ◽  
X Ray ◽  
Tert Butyl ◽  
Boron Halides ◽  
System 2

AbstractWhile the diphosphadiboretane (tBuP=Btmp)2, 1, reacts with boron trihalides BX3 (X = Cl, Br, I) with BN cleavage producing a number of unidentifiable products, a new tricyclic BP ring system 2, containing B3P3, PB2C2 and C6 rings, results from the combination of PhBCl2 and 1. B-Chlorocatecholborane and 1 give access to the diborylphosphane 3, tmpBCl-PtBu-cat (cat = C6H4O2B). This shows that the selectivity of the reactions increases as the Lewis acidity of boron halide decreases. The structure of compounds 2 and 3 were determined by X-ray structure analysis. The bicyclic (tmpBP)2 4 forms no adducts with MeI, CF3SO2Me or Ph3C(SnCl5). However, it adds B(C6F5)3 to give 10, the first BX3 adduct of this bicycle that is fully characterized including its molecular structure.

The squalestatins: Cleavage of the bicyclic core via the novel 2,8,9-trioxabicyclo[3.3.1]nonane ring system

1994 ◽  
Vol 35 (11) ◽  
pp. 1789-1792 ◽  
Author(s):  
Daniele Andreotti ◽  
Panayiotis A. Procopiou ◽  
Nigel S. Watson
Keyword(s):  
Ring System ◽  
The Novel
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