Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

1999 ◽  
pp. 915-916 ◽  
Author(s):  
George R. Pettit ◽  
Jun-ping Xu ◽  
Diane E. Gingrich ◽  
Michael D. Williams ◽  
Dennis L. Doubek ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Marine Sponge ◽  
Antineoplastic Agents ◽  
New Guinea

ChemInform Abstract: Antineoplastic Agents. Part 395. Isolation and Structure of Agelagalastatin from the Papua New Guinea Marine Sponge Agelas sp.

ChemInform ◽  
2010 ◽  
Vol 30 (37) ◽  
pp. no-no
Author(s):  
George R. Pettit ◽  
Jun-ping Xu ◽  
Diane E. Gingrich ◽  
Michael D. Williams ◽  
Dennis L. Doubek ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Marine Sponge ◽  
Antineoplastic Agents ◽  
New Guinea

Antineoplastic agents. 251. Isolation and structure of stylostatin 1 from the Papua New Guinea marine sponge Stylotella aurantium

1992 ◽  
Vol 57 (26) ◽  
pp. 7217-7220 ◽  
Author(s):  
George R. Pettit ◽  
Jayaram K. Srirangam ◽  
Delbert L. Herald ◽  
Karen L. Erickson ◽  
Dennis L. Doubek ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Marine Sponge ◽  
Antineoplastic Agents ◽  
New Guinea

Antineoplastic agents. 251. Isolation and structure of stylostatin 1 from the Papua New Guinea marine sponge Stylotella sp. [Erratum to document cited in CA118(5):36157a]

1993 ◽  
Vol 58 (11) ◽  
pp. 3222-3222 ◽  
Author(s):  
George R. Pettit ◽  
Jayaram K. Srirangam ◽  
Delbert L. Herald ◽  
Karen L. Erickson ◽  
Dennis L. Doubek ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Marine Sponge ◽  
Antineoplastic Agents ◽  
New Guinea

scholarly journals Ceratamines A and B, Antimitotic Heterocyclic Alkaloids Isolated from the Marine Sponge Pseudoceratina sp. Collected in Papua New Guinea.

ChemInform ◽  
2004 ◽  
Vol 35 (15) ◽  
Author(s):  
Emiliano Manzo ◽  
Rob van Soest ◽  
Lohi Matainaho ◽  
Michel Roberge ◽  
Raymond J. Andersen
Keyword(s):  
Papua New Guinea ◽  
Marine Sponge ◽  
New Guinea

Antineoplastic agents. 168. Isolation and structure of axinohydantoin

1990 ◽  
Vol 68 (9) ◽  
pp. 1621-1624 ◽  
Author(s):  
George R. Pettit ◽  
Cherry L. Herald ◽  
John E. Leet ◽  
Rajesh Gupta ◽  
Daniel E. Schaufelberger ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Antineoplastic Agents ◽  
New Guinea ◽  
X Ray ◽  
Imidazole Derivatives ◽  
Eastern State ◽  
Present Experience ◽  
Caroline Islands

Western (Palau) and Eastern (State of Truk) Caroline Islands and Papua New Guinea sponges of the genera Axinella and Hymeniacidon were found to contain the cytostatic (PS ED50 2.5 and 2.0 (μg/mL) and antineoplastic (PS T/C 143 at 3.6 mg/kg and T/C 138 at 3.6 mg/kg) pyrrologuanidines 1a and 1b. The related hydantoin 2, designated axinohydantoin, was also isolated from an Axinella sp. and its structure was assigned by X-ray crystallographic techniques. Present experience with sponges in the Axinella and Hymeniacidon genera suggests that the previously known hymenialdisine (1b) and analogous imidazole derivatives may be widely distributed among these and related orange colored Porifera. Keywords: axinohydantoin, hymenialdisine, Axinella, Hymeniacidon, cystostatic.

scholarly journals Tedanolide C: A Potent New 18-Membered Ring Cytotoxic Macrolide Isolated from the Papua New Guinea Marine Sponge Ircinia sp.

ChemInform ◽  
2006 ◽  
Vol 37 (33) ◽  
Author(s):  
Camille Chevallier ◽  
Tim S. Bugni ◽  
Xidong Feng ◽  
Mary Kay Harper ◽  
Anita M. Orendt ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Marine Sponge ◽  
New Guinea ◽  
Membered Ring ◽  
Cytotoxic Macrolide

Structural Variations to the 9-N-Methyladeninium Diterpenoid Hybrid Commonly Isolated from Agelas Sponges

2010 ◽  
Vol 63 (6) ◽  
pp. 915 ◽  
Author(s):  
Laurent Calcul ◽  
Karen Tenney ◽  
Joseline Ratnam ◽  
James H. McKerrow ◽  
Phillip Crews
Keyword(s):  
Papua New Guinea ◽  
Trypanosoma Brucei ◽  
Marine Sponge ◽  
Inhibitory Activity ◽  
New Guinea ◽  
Jurkat Cells ◽  
Structural Variations ◽  
Data Analyses ◽  
Pure Compounds ◽  
Agelasine B

Four novel 9-N-methyladeninium diterpenoids, agelasine M (3), 2-oxo-agelasine B (4), gelasine A (5), and gelasine B (6) accompanied by the known-agelasine B (1) and F (2) were isolated from the marine sponge Agelas sp. collected in Papua New Guinea. Compounds 3–6 represent higher unsaturated 9-N-methyladeninium bicyclic diterpenoid derivatives including 5 and 6 as unusual norditerpenoid-agelasines. Their structures were elucidated through detailed physical data analyses and comparison with literature properties. All pure compounds were evaluated for inhibitory activity against Trypanosoma brucei as well as for cytotoxicity against Jurkat cells.

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