Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S )-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid and its glutamyl cleavage product

1999 ◽  
pp. 1495-1504 ◽  
Author(s):  
Jonathan H. Marriott ◽  
Stephen Neidle ◽  
Zbigniew Matusiak ◽  
Vassilios Bavetsias ◽  
Ann L. Jackman ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Thymidylate Synthase ◽  
Cleavage Product ◽  
The Novel ◽  
Thymidylate Synthase Inhibitor ◽  
Synthase Inhibitor

Destruction of WiDr multicellular tumor spheroids?with the novel thymidylate synthase inhibitor 1843U89?at physiological thymidine concentrations

1994 ◽  
Vol 33 (6) ◽  
pp. 455-459
Author(s):  
Sheila D. Banks ◽  
Kathleen A. Waters ◽  
Linda L. Barrett ◽  
Scott Dickerson ◽  
William Pendergast ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
The Novel ◽  
Multicellular Tumor Spheroids ◽  
Tumor Spheroids ◽  
Thymidylate Synthase Inhibitor ◽  
Synthase Inhibitor

Evaluation of the factors influencing the clearance of the novel thymidylate synthase inhibitor ZD9331

1999 ◽  
Vol 35 ◽  
pp. S285 ◽  
Author(s):  
S.G. Diab ◽  
S.Y. Rha ◽  
C. Britten ◽  
S.D. Baker ◽  
R. Smith ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
The Novel ◽  
Factors Influencing ◽  
Thymidylate Synthase Inhibitor ◽  
Synthase Inhibitor

The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells

2014 ◽  
Vol 73 (6) ◽  
pp. 1273-1283 ◽  
Author(s):  
Kaamar Azijli ◽  
Ingrid A. M. van Roosmalen ◽  
Jorn Smit ◽  
Saravanan Pillai ◽  
Masakazu Fukushima ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Thymidylate Synthase ◽  
Small Cell ◽  
The Novel ◽  
Small Cell Lung ◽  
Thymidylate Synthase Inhibitor ◽  
Synthase Inhibitor
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