Results of the second inventory on quality assurance/quality control (QA/QC) and good laboratory practice (GLP) for European Union National Reference Laboratories for residue analyses†‡

The Analyst ◽  
1998 ◽  
Vol 123 (12) ◽  
pp. 2555-2557 ◽  
Author(s):  
Ronald C. Schothorst ◽  
Rainer W. Stephany
Keyword(s):  
European Union ◽  
Quality Control ◽  
Quality Assurance ◽  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
National Reference ◽  
Good Laboratory

scholarly journals Chemical Laboratory House Keeping: Safety and Practices

NUTA Journal ◽  
2019 ◽  
Vol 6 (1-2) ◽  
pp. 25-27
Author(s):  
Khuma Sharma Dhital
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Good Laboratory Practice ◽  
Laboratory Safety ◽  
Laboratory Practice ◽  
Chemical Laboratory ◽  
Good Laboratory ◽  
Healthy Workplace

A clean lab is safe lab. Good laboratory practice and laboratory housekeeping makes the laboratory quality assurance and quality control. It helps for laboratory safety and management for the reliable and accurate results. Laboratory housekeeping is the fundamental to ensure safe and healthy workplace to work for the staff, teachers and researchers.

scholarly journals Boost Up Quality Assurance through Regular Evaluation of Proficiency Testing Performance

2018 ◽  
Vol 3 (1) ◽  
pp. 3-7
Author(s):  
Rajendra Dev Bhatt ◽  
Dipesh Tamrakar ◽  
Bishal Maharjan ◽  
Rajendra Dual ◽  
Raj Kumar Shrestha ◽  
...  
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Biochemical Parameters ◽  
Index Score ◽  
Good Laboratory Practice ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Laboratory Practice ◽  
Variation Index ◽  
Good Laboratory

Background: Participation in External Quality Assessment (EQA) program with practice of Internal Quality Control (IQC) is the excellent indicator of good laboratory practice (GLP) to assure quality services. EQA is an essential component of Quality Assurance to assess the analytical performance compared within same methods of other laboratories.  It is also important to detect equipments failure, identifying reagent problems, reviewing staff training as well as to initiate and evaluate corrective action timely.Methods: This is descriptive analysis of the feedback received from EQAS body for twenty routine biochemical parameters which are most commonly performed in the Clinical Biochemistry Laboratory of Dhulikhel Hospital. Variation Index Score (VIS), Overall Mean VIS (OMVIS) and Standard Deviation Index (SDI) of all parameters for the year 2014 and 2015 were analyzed statistically.Results: On the analysis of twenty routine biochemical parameters regularly participated in EQAS, over all mean variation index score (OMVIS) of individual tests found 55%, 30% and 15% under good, very good and satisfactory category respectively.Conclusion: Participation and periodic evaluation of EQAS indicators along with practice of internal quality control has been galvanizing good laboratory practice and scientifically it boost up quality service in clinical laboratories. 

Benefits of Good Laboratory Practice as a Tool to Improve Testing

1993 ◽  
Vol 12 (6) ◽  
pp. 528-532
Author(s):  
Dian Turnheim
Keyword(s):  
Quality Assurance ◽  
Information Exchange ◽  
Economic Cooperation ◽  
Good Laboratory Practice ◽  
Compliance Monitoring ◽  
Laboratory Practice ◽  
International Harmonisation ◽  
Good Laboratory

The Organization for Economic Cooperation and Development (OECD) has promoted Good Laboratory Practice (GLP) since the mid 1970s. This paper describes the development of the concept through international harmonisation, Quality Assurance (QA), and compliance monitoring. Ultimately this process permits Mutual Acceptance of Data (MAD). An important aspect of the OECD's programme is the promotion of related training and information exchange.

scholarly journals Commutability Limitations Influence Quality Control Results with Different Reagent Lots

2011 ◽  
Vol 57 (1) ◽  
pp. 76-83 ◽  
Author(s):  
WGreg Miller ◽  
Aybala Erek ◽  
Tina D Cunningham ◽  
Olajumoke Oladipo ◽  
Mitchell G Scott ◽  
...  
Keyword(s):  
Quality Control ◽  
T Test ◽  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
Clinical Patient ◽  
Patient Sample ◽  
Significant Difference ◽  
Good Laboratory ◽  
Sample Measurement

BACKGROUND Good laboratory practice includes verifying that each new lot of reagents is suitable for use before it is put into service. Noncommutability of quality control (QC) samples with clinical patient samples may preclude their use to verify consistency of results for patient samples between different reagent lots. METHODS Patient sample results and QC data were obtained from reagent lot change verification records for 18 QC materials, 661 reagent lot changes, 1483 reagent lot change–QC events, 82 analytes, and 7 instrument platforms. The significance of between-lot differences in the results for QC samples compared with those for patient samples was assessed by a modified 2-sample t test adjusted for heterogeneity of QC and patient sample measurement variances. RESULTS Overall, 40.9% of reagent lot change–QC events had a significant difference (P < 0.05) between results for QC samples compared with results for patient samples between 2 reagent lots. For QC results with differences <1.0 SD interval (83.1% of total), 37.7% were significantly different from the changes observed for patient samples. For QC results with differences ≥1.0 SD interval (16.9% of total), 57.0% were significantly different from those for patient samples. CONCLUSIONS Occurrence of noncommutable results for QC materials was frequent enough that the QC results could not be used to verify consistency of results for patient samples when changing lots of reagents.

Practical Quality Improvement Applied to Toxicology Studies

1991 ◽  
Vol 10 (3) ◽  
pp. 387-391
Author(s):  
A. W. Waddell
Keyword(s):  
Quality Assurance ◽  
Quality Improvement ◽  
Cost Effectiveness ◽  
Regulatory Compliance ◽  
Good Laboratory Practice ◽  
Quality Assurance Program ◽  
Laboratory Practice ◽  
Good Laboratory ◽  
The Cost

Elements that are required for regulatory compliance can be used as powerful resources to achieve quality improvement. One such approach, using the output from a Good Laboratory Practice quality assurance program, is described and has produced marked improvements in the conduct and reporting of toxicology studies. The cost effectiveness of quality assurance programs under such circumstances is discussed.

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