Mutual diffusion in aqueous solution of ethylene glycol oligomers at 25 °C

1998 ◽  
Vol 94 (17) ◽  
pp. 2571-2576 ◽  
Author(s):  
L. Paduano ◽  
R. Sartorio ◽  
G. D'Errico ◽  
V. Vitagliano
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Mutual Diffusion ◽  
Glycol Oligomers

Immuno-compatibility of desaminotyrosine and desaminotyrosyl tyrosine functionalized star-shaped oligo(ethylene glycol)s with different molecular weights

2015 ◽  
Vol 1718 ◽  
pp. 97-102 ◽  
Author(s):  
Toralf Roch ◽  
Konstanze K. Julich-Gruner ◽  
Axel T. Neffe ◽  
Nan Ma ◽  
Andreas Lendlein
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Average Molecular Weight ◽  
Molecular Weights ◽  
Immunological Effects ◽  
Microbial Products ◽  
Low Levels ◽  
Chain Lengths ◽  
Immunological Evaluation

ABSTRACTPolymer-based therapeutic strategies require biomaterials with properties and functions tailored to the demands of specific applications leading to an increasing number of newly designed polymers. For the evaluation of those new materials, comprehensive biocompatibility studies including cyto-, tissue-, and immunocompatibility are essential. Recently, it could be demonstrated that star-shaped amino oligo(ethylene glycol)s (sOEG) with a number average molecular weight of 5 kDa and functionalized with the phenol-derived moieties desaminotyrosine (DAT) or desaminotyrosyl tyrosine (DATT) behave in aqueous solution like surfactants without inducing a substantial cytotoxicity, which may qualify them as solubilizer for hydrophobic drugs in aqueous solution. However, for biomedical applications the polymer solutions need to be free of immunogenic contaminations, which could result from inadequate laboratory environment or contaminated starting material. Furthermore, the materials should not induce uncontrolled or undesired immunological effects arising from material intrinsic properties. Therefore, a comprehensive immunological evaluation as perquisite for application of each biomaterial batch is required. This study investigated the immunological properties of sOEG-DAT(T) solutions, which were prepared using sOEG with number average molecular weights of 5 kDa, 10 kDa, and 20 kDa allowing analyzing the influence of the sOEG chain lengths on innate immune mechanisms. A macrophage-based assay was used to first demonstrate that all DAT(T)-sOEG solutions are free of endotoxins and other microbial contaminations such as fungal products. In the next step, the capacity of the different DAT(T)-functionalized sOEG solutions to induce cytokine secretion and generation of reactive oxygen species (ROS) was investigated using whole human blood. It was observed that low levels of the pro-inflammatory cytokines interleukin(IL)-1β and IL-6 were detected for all sOEG solutions but only when used at concentrations above 250 µg·mL-1. Furthermore, only the 20 kDa sOEG-DAT induced low amounts of ROS-producing monocytes. Conclusively, the data indicate that the materials were not contaminated with microbial products and do not induce substantial immunological adverse effectsin vitro,which is a prerequisite for future biological applications.

Electrochemical studies of the Pb2+/Pb(Hg) system in aqueous and aqueous ethylene glycol solutions

1979 ◽  
Vol 57 (14) ◽  
pp. 1801-1803 ◽  
Author(s):  
Tibor Rabockai
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Organic Solvent ◽  
Electrochemical Behavior ◽  
Experimental Error ◽  
Electrochemical Studies ◽  
Temperature Range ◽  
All Solutions ◽  
Aqueous Ethylene Glycol ◽  
Current Reversal

The electrochemical behavior of the Pb2+/Pb(Hg) system in aqueous and aqueous ethylene glycol solutions is studied in the temperature range of 20.0 to 50.0 °C by means of current reversal chronopotentiometry. It is shown that the reduction of Pb2+ ion is reversible and that kinetic or catalytic complications are not present. The value of dE1/2/dT is −0.6 mV/deg in the aqueous solution and −0.5 mV/deg in the solution with 56% (w/w) or higher concentrations of the organic solvent. In the above concentration range of ethylene glycol the activation energies of diffusion and viscosity vary from 4.3 × 103 to 7.2 × 103 cal mol−1 and from 3.7 × 103 to 6.7 × 103 cal mol−1, respectively. For all solutions the solvodynamic mean radius of the diffusing species remains constant within the experimental error, suggesting that the diffusing species is always the hydrated Pb2+ ion.

Mutual Diffusion Coefficients of Water + Ethylene Glycol and Water + Glycerol Mixtures

1996 ◽  
Vol 41 (4) ◽  
pp. 876-879 ◽  
Author(s):  
G. Ternström ◽  
A. Sjöstrand ◽  
G. Aly ◽  
Å. Jernqvist
Keyword(s):  
Ethylene Glycol ◽  
Diffusion Coefficients ◽  
Mutual Diffusion ◽  
Water Glycerol

scholarly journals Energetics of fragmentation for cationized poly(ethylene glycol) oligomers

2010 ◽  
Vol 24 (16) ◽  
pp. 2471-2473 ◽  
Author(s):  
Antony Memboeuf ◽  
László Drahos ◽  
Károly Vékey ◽  
György Lendvay
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Oligomers

Fe3O4 nanoparticles functionalized with poly(ethylene glycol) for the selective separation and enrichment of Au(iii)

2020 ◽  
Vol 44 (4) ◽  
pp. 1313-1319
Author(s):  
Xu Yang ◽  
Kunhao Yang ◽  
Li Wu ◽  
Jingkui Yang ◽  
Yujian He
Keyword(s):  
Aqueous Solution ◽  
Magnetic Nanoparticles ◽  
Ethylene Glycol ◽  
Fe3o4 Nanoparticles ◽  
Selective Separation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Mechanism of Fe3O4@CPTES@PEG magnetic nanoparticles for selectively adsorbing Au(iii) from aqueous solution at pH = 1.0.

Sign in / Sign up

Export Citation Format

Share Document