Mass median particle size determination of an active compound in a binary mixture using near-infrared spectroscopy

1998 ◽  
Vol 35 (4) ◽  
pp. 133-134 ◽  
Author(s):  
Paul Frake ◽  
Christopher N. Luscombe ◽  
David R. Rudd ◽  
Janette Waterhouse ◽  
Paul Frake ◽  
...  
Keyword(s):  
Particle Size ◽  
Infrared Spectroscopy ◽  
Binary Mixture ◽  
Near Infrared ◽  
Size Determination ◽  
Median Particle Size ◽  
Particle Size Determination ◽  
Median Particle ◽  
Mass Median

Near-infrared mass median particle size determination of lactose monohydrate, evaluating several chemometric approaches

The Analyst ◽  
1998 ◽  
Vol 123 (10) ◽  
pp. 2043-2046 ◽  
Author(s):  
P. Frake ◽  
C. N. Luscombe ◽  
D. R. Rudd ◽  
I. Gill ◽  
J. Waterhouse ◽  
...  
Keyword(s):  
Particle Size ◽  
Near Infrared ◽  
Size Determination ◽  
Median Particle Size ◽  
Lactose Monohydrate ◽  
Particle Size Determination ◽  
Median Particle ◽  
Mass Median

Obtaining and research of pharmaceutical properties of antiemetics in a form of powder for inhalation

2021 ◽  
Author(s):  
Igor M. Ivanov ◽  
Tatiana B. Pechurina ◽  
Nikolai G. Vengerovich ◽  
Mikhail A. Yudin ◽  
Aleksandr S. Nikiforov ◽  
...  
Keyword(s):  
Particle Size ◽  
Dosage Form ◽  
Production Method ◽  
Particle Fraction ◽  
Median Particle Size ◽  
Antiemetic Drugs ◽  
Median Particle ◽  
Pharmaceutical Properties ◽  
Mass Median ◽  
Respirable Particle

Samples of antiemetic drugs (ondansetronum, palonosetronum, metoclopramidum) in the form of powder for inhalation have been developed by the method of spray drying. The granulometric composition, hygroscopicity and aerodynamic distribution of aerosol particles of the drugs have been investigated. The dosage form of the powder for inhalation of antiemetics (ondansetronum and palonosetronum) in terms of its particle size distribution, hygroscopicity and content of the agent corresponds to those for inhalation using dry powder inhalers. In the study of the phase-dispersed composition of aerosol, ondansetronum and palonosetronum in the dosage form of powder for inhalation as part of the HandiHaler inhaler (at a flow rate of 60 l / min) showed high rates of the released dose up to 72-76%, respirable particle fraction (up to 5 m) up to 54 -56% and a mass median particle size of about 3 microns. Obtaining the inhaled form of metoclopramide requires optimization of the production method for receiving the product with acceptable pharmaceutical properties.

Flow visualization and particle size determination of primary clusters in a water-based magnetic fluid

2005 ◽  
Vol 289 ◽  
pp. 392-395 ◽  
Author(s):  
Hiroshige Kikura ◽  
Junichiro Matsushita ◽  
Osamu Hirashima ◽  
Masanori Aritomi ◽  
Isao Nakatani
Keyword(s):  
Particle Size ◽  
Flow Visualization ◽  
Magnetic Fluid ◽  
Size Determination ◽  
Particle Size Determination ◽  
Water Based
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