Complementary use of capillary gas chromatography–mass spectrometry (ion trap) and gas chromatography–inductively coupled plasma mass spectrometry for the speciation of volatile antimony, tin and bismuth compounds in landfill and fermentation gases†

The Analyst ◽  
1998 ◽  
Vol 123 (5) ◽  
pp. 815-820 ◽  
Author(s):  
Jörg Feldmann ◽  
Iris Koch ◽  
William R. Cullen
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Inductively Coupled Plasma ◽  
Ion Trap ◽  
Gas Chromatography Mass Spectrometry ◽  
Inductively Coupled ◽  
Bismuth Compounds ◽  
Chromatography Mass Spectrometry ◽  
Plasma Mass Spectrometry

Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry.

1986 ◽  
Vol 32 (2) ◽  
pp. 325-328 ◽  
Author(s):  
V A Soo ◽  
R J Bergert ◽  
D G Deutsch
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Detector Response ◽  
Capillary Gc ◽  
Chromatography Mass Spectrometry ◽  
Nitrogen Phosphorus Detector ◽  
Sedative Drugs ◽  
Nitrogen Phosphorus

Abstract We describe a quantitative screen for hypnotic-sedative drugs in which we use capillary gas chromatography with a nitrogen-phosphorus detector (GC/NPD) as the primary method and capillary gas chromatography-mass spectrometry (GC-MS) for confirmation. GC retention times of the acid-extracted underivatized drugs were stable (CVs less than 1%), and the detector response varied linearly over a 20-fold concentration range with a mean correlation coefficient for 11 drugs of 0.989. The limits of detection were satisfactory (0.5 mg/L in a 0.5-mL serum sample and 1-microL injection volume), as were precision (average CV 5.2% within day, 6.4% between day). The complementary use of capillary GC-MS not only unambiguously confirms presumptive peaks identified by GC, but also prevents reports of false positives and identifies compounds not included in the quantitative GC screen that may be listed in the GC-MS library.

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