Nucleophilic substitution of acyl chlorides by electrogenerated polysulfide ions in N,N-dimethylacetamide

1997 ◽  
pp. 1759-1764 ◽  
Author(s):  
Julie Robert ◽  
Meriem Anouti ◽  
Mohamed Abarbri ◽  
Jacky Paris
Keyword(s):  
Nucleophilic Substitution ◽  
Acyl Chlorides ◽  
Polysulfide Ions

scholarly journals A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 530-537 ◽  
Author(s):  
Moisés Romero-Ortega ◽  
Michelle Trujillo-Lagunas ◽  
Ignacio Medina-Mercado ◽  
Ivann Zaragoza-Galicia ◽  
Horacio Olivo
Keyword(s):  
Nucleophilic Substitution ◽  
Intramolecular Cyclization ◽  
Nitrogen Heterocycles ◽  
Cyclization Reaction ◽  
Substitution Reactions ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Acyl Chlorides ◽  
Nucleophilic Substitution Reactions ◽  
One Pot Synthesis

A convenient two-step, one-pot synthesis of 4-chloro-2-(trichloromethyl)pyrimidines starting from 2-(trichloromethyl)-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared by a sequential acylation/intramolecular cyclization reaction between 2-(trichloromethyl)-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 4-chloro-2-(trichloromethyl)pyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.

scholarly journals Nucleophilic Substitution of Alkyl Halides by Electrogenerated Polysulfide Ions in N,N-dimethylacetamide.

1999 ◽  
Vol 53 ◽  
pp. 513-520 ◽  
Author(s):  
Abdelkader Ahrika ◽  
Julie Robert ◽  
Meriem Anouti ◽  
Jacky Paris ◽  
Zong-Hui Jiang ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Alkyl Halides ◽  
Polysulfide Ions
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