Heterocyclic Chemistry

Heterocyclic chemistry has provided an inexhaustible source of pharmaceutical molecules. Heterocyclic compounds such as benzothiazole moieties and its derivatives area substantial class of compounds in pharmaceutical chemistry and exhibited therapeutic capabilities, such as antitumor, anticancer, antioxidant, antidiabetic, antiviral, antimicrobial, antimalarial, anthelmintic and other activities. Besides, some antibiotics such as penicillin and cephalosporin have heterocyclic moiety. The growing prevalence of multi-drug resistant pathogens represents serious global concern,which requires the development of new antimicrobial drugs. Moreover, the emergence of pandemic SARSCoV-2 causing Covid-19 disease and all these health dilemmas urge the scientific community to examine the possible antimicrobial and antiviral capacities of some bioactive benzothiazole derivatives against these severe causative agents.This mini-review highlights some recent scientific literature on different benzothiazole molecules and their derivatives. It turns out that, there are numerous synthesized benzothiazole derivatives which exhibited different mode of actions against microorganisms or viruses and accordingly suggested them as an active candidate in the discovery of new antimicrobial or antiviral agents for clinical development. The recommended bioactive benzothiazole derivatives mentioned in the current study are mainly Schiff bases, azo dyes and metal complexes benzothiazole derivatives; the starting material for most of these derivatives are 2-aminobenzothiazole although careful pharmaceutical studies should be conducted to ensure the safety and efficacy of these bioactive synthesized molecules as an antimicrobial or antiviral drug in the future.

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Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review

Current Organic Chemistry ◽

10.2174/1385272823666191023122704 ◽

2020 ◽

Vol 23 (21) ◽

pp. 2271-2294 ◽

Cited By ~ 1

Author(s):

Divya Utreja ◽

Shivali Sharma ◽

Akhil Goyal ◽

Komalpreet Kaur ◽

Sonia Kaushal

Keyword(s):

Tyrosine Kinases ◽

Biological Activities ◽

Polymeric Materials ◽

Tubulin Polymerization ◽

Quinoline Derivatives ◽

Heterocyclic Chemistry ◽

Biological Profile ◽

Drug Candidates ◽

Anti Hiv ◽

Quinolinium Salts

Heterocyclic chemistry is the only branch of chemistry that has applications in varied areas such as dyes, photosensitizers, coordination compounds, polymeric materials, biological, and many other fields. Quinoline and its derivatives have always engrossed both synthetic chemists and biologists because of their diverse chemical and pharmacological properties as these ring systems can be easily found in various natural products, especially in alkaloids. Among alkaloids, quinoline derivatives i.e. quinolinium salts have attracted much attention nowadays owing to their diverse biological profile such as antimicrobial, antitumor, antifungal, hypotensive, anti-HIV, analgesics and anti-inflammatory, etc. Quinoline and its analogs have recently been examined for their modes of function in the inhibition of tyrosine kinases, proteasome, tubulin polymerization, topoisomerase, and DNA repair. These observations have been guiding scientists for the expansion of new quinoline derivatives with improved and varied biological activities. Quinolinium salts have immense possibilities and scope to investigate these compounds as potential drug candidates. Therefore, we shall present a concise compilation of this work to aid in present knowledge and to help researchers explore an interesting quinoline class having medicinal potential.

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Benzotriazol-1-yl-Acetone as a Building Block in Heterocyclic Chemistry: A Route to Benzotriazolylpyridazines, Benzotriazolylphthalazines and Benzotriazolylpyrazolo[5,1-c]-1,2,4-triazines

Journal of Chemical Research ◽

10.1177/174751989902301106 ◽

1999 ◽

Vol 23 (11) ◽

pp. 648-649

Author(s):

Abdul Aziz Al-Naggar ◽

Mervat Mohammed Abdel-Khalik ◽

Mohammed Hilmy Elnagdi

Keyword(s):

Double Bond ◽

Building Block ◽

Ethyl Cyanoacetate ◽

Diazonium Salts ◽

Heterocyclic Chemistry

Benzotriazolylacetone is coupled with aromatic diazonium salts to yield arylhydrazones, which can be condensed with ethyl cyanoacetate yielding pyridazinones whose reactivity towards activated double bond systems is investigated.

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ChemInform Abstract: Linked Pummerer-Mannich Ion Cyclizations for Heterocyclic Chemistry

ChemInform ◽

10.1002/chin.200234290 ◽

2010 ◽

Vol 33 (34) ◽

pp. no-no

Author(s):

Albert Padwa ◽

Scott K. Bur ◽

Diana M. Danca ◽

John D. Ginn ◽

Stephen M. Lynch

Keyword(s):

Heterocyclic Chemistry

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