scholarly journals CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients

2015 ◽  
Vol 16 (1) ◽  
pp. 88-95 ◽  
Author(s):  
B A Maganda ◽  
O M S Minzi ◽  
E Ngaimisi ◽  
A A R Kamuhabwa ◽  
E Aklillu
Keyword(s):  
Plasma Concentration ◽  
Treatment Response ◽  
Plasma Exposure ◽  
Poor Treatment ◽  
Poor Treatment Response

scholarly journals Antipsychotic plasma levels in the assessment of poor treatment response in schizophrenia

2017 ◽  
Vol 137 (1) ◽  
pp. 39-46 ◽  
Author(s):  
R. McCutcheon ◽  
K. Beck ◽  
E. D'Ambrosio ◽  
J. Donocik ◽  
C. Gobjila ◽  
...  
Keyword(s):  
Treatment Response ◽  
Plasma Levels ◽  
Poor Treatment ◽  
Poor Treatment Response

scholarly journals Using informant discrepancies in report of parent–adolescent conflict to predict hopelessness in adolescent depression

2020 ◽  
pp. 135910452096976
Author(s):  
Erling W Rognli ◽  
Marianne Aalberg ◽  
Nikolai Olavi Czajkowski
Keyword(s):  
Treatment Response ◽  
Adolescent Depression ◽  
Cross Validation ◽  
Informant Discrepancies ◽  
Difference Scores ◽  
Poor Treatment ◽  
Important Symptom ◽  
Adolescent Conflict ◽  
Preliminary Support ◽  
Poor Treatment Response

Hopelessness is an important symptom of adolescent depression, being associated with both risk of suicide and poor treatment response, but predictors of hopelessness are understudied. Conflict with parents is common in adolescent depression, but parents and adolescents often disagree when reporting conflict severity. Discrepancy in reporting may be an indicator of the parent–adolescent dyad lacking a shared representation of the state of their relationship. This could make conflicts seem unresolvable to the adolescent, leading to expectations of persistent stress and lack of support, increasing hopelessness. This study employed latent difference scores, ordinal regression and cross-validation to evaluate the hypothesis that discrepancy in report of parent–adolescent conflict would predict hopelessness among depressed adolescents. Parents reporting less conflict than the adolescent was associated with increased adolescent hopelessness, giving preliminary support to the hypothesis.

scholarly journals Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1

Hepatology ◽  
2003 ◽  
Vol 38 (6) ◽  
pp. 1592-1592 ◽  
Author(s):  
Tobias Mueller ◽  
Reinhard Gesner ◽  
Christoph Sarrazin ◽  
Carola Graf ◽  
Juliane Halangk ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Response ◽  
Genotype 1 ◽  
Hcv Genotype ◽  
Apolipoprotein E4 ◽  
Poor Treatment ◽  
E4 Allele ◽  
Hcv Genotype 1 ◽  
Poor Treatment Response

Prefrontal cortical sulcal widening associated with poor treatment response to clozapine

2001 ◽  
Vol 48 (2-3) ◽  
pp. 173-176 ◽  
Author(s):  
P.Eric Konicki ◽  
Ken Y Kwon ◽  
Vickie Steele ◽  
John White ◽  
Matthew Fuller ◽  
...  
Keyword(s):  
Treatment Response ◽  
Prefrontal Cortical ◽  
Poor Treatment ◽  
Poor Treatment Response

scholarly journals EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients

2021 ◽  
Vol 20 ◽  
pp. 153303382110414
Author(s):  
Feiyue Zhu ◽  
Yesong Fu ◽  
Xiaojuan He
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Treatment Response ◽  
Clinical Features ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Translation Initiation Factor ◽  
Cell Transplant ◽  
Poor Treatment ◽  
Poor Treatment Response

Objective: This study was undertaken to investigate eukaryotic translation initiation factor 3 subunit B (EIF3B) expression and its clinical value for indicating disease progression and prognosis in adult Philadelphia chromosome negative acute lymphoblastic leukemia (Ph− ALL) patients. Methods: Totally, 76 adult Ph− ALL patients and 30 healthy donors (HDs) were included. Bone marrow (BM) samples before therapy (baseline), after 4-week therapy of Ph− ALL patients and the BM samples of HDs were collected. Then, EIF3B expression in BM was detected by reverse transcription quantitative polymerase chain reaction. Results: EIF3B expression was increased in Ph− ALL patients compared with HDs, which distinguished Ph− ALL patients from HDs (area under the curve [AUC]: 0.928; 95% confidence interval [CI]: 0.882−0.974) by receiver operating characteristic curve. Furthermore, higher baseline EIF3B expression was associated with elevated white blood cell and bone marrow blasts, while it was associated with lower complete remission (CR) within 4 weeks and less allogeneic hematopoietic stem cell transplant achievements in Ph− ALL patients. Additionally, higher baseline EIF3B expression was associated with decreased disease-free survival but not overall survival. However, it was associated with raised 1-year mortality and 3-year mortality in Ph− ALL patients. After 4-week therapy, EIF3B expression was reduced in total Ph− ALL patients. Notably, the reduction of EIF3B expression was more obvious in Ph− ALL patients who achieved CR within 4 weeks compared with Ph− ALL patients who did not achieve CR within 4 weeks. Conclusion: EIF3B overexpression is related to worsened clinical features, poor treatment response and survival in adult Ph− ALL patients.

scholarly journals The association between neutrophil-to-lymphocyte ratio and treatment response in nasopharyngeal cancer patients of Cipto Mangunkusumo General Hospital in 2015-2018: A retrospective cohort study.

2019 ◽  
Vol 5 (suppl) ◽  
pp. 123-123
Author(s):  
Rahmat Cahyanur ◽  
Cosphiadi Irawan ◽  
Sari Rahmawati ◽  
Nadia Nasman
Keyword(s):  
Treatment Response ◽  
General Hospital ◽  
Nasopharyngeal Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Stage ◽  
First Line ◽  
Lymphocyte Ratio ◽  
Poor Treatment ◽  
The Mean ◽  
Poor Treatment Response

123 Background: Nasopharyngeal Cancer (NPC) is the most common head and neck cancer in Indonesia and mostly diagnosed at advanced stage. The patients with same stage of the disease have shown variety of responses against first line chemotherapy, suggesting other factors that could play a role in determining the treatment outcome. Meanwhile, neutrophil-to-lymphocyte ratio (NLR) has been studied to be a prognostic factor in many malignancies. Objective: This study aimed to determine the association between NLR and treatment response in advanced-stage NPC patients of Cipto Mangunkusumo General Hospital (RSCM) in 2015-2018. Methods: We evaluated the medical record of 45 advanced-stage NPC patients that visited RSCM in 2015-2018 retrospectively. The NLR was calculated using the neutrophil and lymphocyte count prior the first chemotherapy. We categorized NLR ≥ 4 as high. We categorized the treatment response by response (CR and PR) and non-response (SD and PD). Results: There were 45 patients included in this study. Demographic profile of the patients were dominated by male (80,0%) with mean age 45.58 (±14.5) years old. The mean of NLR was 7.396 (±5.182). We found 32 (71.1%) patients had high NLR (cut off > 4). Majority of patients with high NLR (71.9%) did not respond to first line treatment. The association between NLR and treatment response was statistically significant ( p = 0.048). Conclusions: We found that high NLR values are associated with poor treatment response in NPC patients. Keywords: Nasopharyngeal cancer, neutrophil-to-lymphocyte ratio, treatment response.

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