Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant

2015 ◽  
Vol 16 (2) ◽  
pp. 193-201 ◽  
Author(s):  
R Arlanov ◽  
T Lang ◽  
G Jedlitschky ◽  
E Schaeffeler ◽  
T Ishikawa ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Efflux Transporter ◽  
Protein Variants

scholarly journals Isolation and functional characterization of CsLsi2, a cucumber silicon efflux transporter gene

2018 ◽  
Vol 122 (4) ◽  
pp. 641-648 ◽  
Author(s):  
Hao Sun ◽  
Yaoke Duan ◽  
Xiaocui Qi ◽  
Liyang Zhang ◽  
Heqiang Huo ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Efflux Transporter ◽  
Transporter Gene

Functional Characterization of the Heterooligomeric EbrAB Multidrug Efflux Transporter ofBacillus subtilis†

Biochemistry ◽  
2007 ◽  
Vol 46 (17) ◽  
pp. 5218-5225 ◽  
Author(s):  
Zhongge Zhang ◽  
Che Ma ◽  
Owen Pornillos ◽  
Xia Xiu ◽  
Geoffrey Chang ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Efflux Transporter ◽  
Multidrug Efflux ◽  
Ofbacillus Subtilis

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells

2012 ◽  
Vol 33 (4) ◽  
pp. 750-762 ◽  
Author(s):  
Rudolf Arlanov ◽  
Andrew Porter ◽  
Dennis Strand ◽  
Rachel Brough ◽  
Darja Karpova ◽  
...  
Keyword(s):  
Expression System ◽  
Functional Characterization ◽  
Multidrug Transporter ◽  
Fibrosarcoma Cells ◽  
Targeted Expression ◽  
Protein Variants

Cloning and Functional Characterization of Putative Escherichia coli ABC Multidrug Efflux Transporter YddA

2020 ◽  
Vol 30 (7) ◽  
pp. 982-995
Author(s):  
Zhenyue Feng ◽  
Defu Liu ◽  
Ziwen Liu ◽  
Yimin Liang ◽  
Yanhong Wang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Functional Characterization ◽  
Efflux Transporter ◽  
Multidrug Efflux

scholarly journals Structural and Functional Characterization of the VQ Protein Family and VQ Protein Variants from Soybean

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan Zhou ◽  
Yan Yang ◽  
Xinjian Zhou ◽  
Yingjun Chi ◽  
Baofang Fan ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Protein Family ◽  
Protein Variants

scholarly journals Functional Characterization of 22 CYP3A4 Protein Variants to Metabolize Ibrutinib In Vitro

2017 ◽  
Vol 122 (4) ◽  
pp. 383-387 ◽  
Author(s):  
Ren-ai Xu ◽  
Jian Wen ◽  
Pengfei Tang ◽  
Chenchen Wang ◽  
Saili Xie ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Protein Variants

scholarly journals Functional characterization of a novel urate efflux transporter URATv1 ( SLC2A9 ) and its relation to renal hypouricemia.

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Promsuk Jutabha ◽  
Naohiko Anzai ◽  
Kimiyoshi Ichida ◽  
Toru Kimura ◽  
Kenichiro Kitamura ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Efflux Transporter ◽  
Renal Hypouricemia

Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter

2002 ◽  
Vol 282 (2) ◽  
pp. C408-C416 ◽  
Author(s):  
Pejvak Sassani ◽  
Alexander Pushkin ◽  
Eitan Gross ◽  
Alla Gomer ◽  
Natalia Abuladze ◽  
...  
Keyword(s):  
Sodium Bicarbonate ◽  
Mammalian Cells ◽  
Functional Characterization ◽  
Amino Acid Level ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Bicarbonate Transporter ◽  
Sodium Bicarbonate Cotransporter ◽  
Protein Variants

Sodium-bicarbonate cotransporters are homologous membrane proteins mediating the electrogenic or electroneutral transport of sodium and bicarbonate. Of the functionally characterized sodium-bicarbonate cotransporters (NBC), NBC1proteins are known to be electrogenic. Here we report the cloning and functional characterization of NBC4c, a new splice variant of the NBC4 gene. At the amino acid level, NBC4c is 56% identical to NBC1 protein variants and 40% identical to electroneutral NBC3. When expressed in mammalian cells, NBC4c mediates electrogenic sodium-bicarbonate cotransport. The transport of sodium and bicarbonate is chloride independent and is completely inhibited by DIDS. NBC4c transcripts were detected in several tissues including brain, heart, kidney, testis, pancreas, muscle, and peripheral blood leukocytes. The data indicate that NBC4c is an electrogenic sodium-bicarbonate cotransporter. The finding that both NBC1 and NBC4c proteins function as electrogenic sodium-bicarbonate cotransporters will aid in determining the structural motifs responsible for this unique functional property, which distinguishes these transporters from other members of the bicarbonate transporter superfamily.

scholarly journals Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitro

2019 ◽  
Vol 125 (4) ◽  
pp. 337-344 ◽  
Author(s):  
Ying‐Hui Li ◽  
Qian‐Meng Lin ◽  
Ni‐Hong Pang ◽  
Xiao‐Dan Zhang ◽  
Huan‐Le Huang ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Protein Variants
Sign in / Sign up

Export Citation Format

Share Document