scholarly journals Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide

2014 ◽  
Vol 15 (2) ◽  
pp. 153-157 ◽  
Author(s):  
J L Del-Aguila ◽  
R M Cooper-DeHoff ◽  
A B Chapman ◽  
J G Gums ◽  
A L Beitelshees ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Meta Analysis ◽  
Potassium Response

scholarly journals An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos

2019 ◽  
Vol 143 (3) ◽  
pp. 957-969 ◽  
Author(s):  
Christopher R. Gignoux ◽  
Dara G. Torgerson ◽  
Maria Pino-Yanes ◽  
Lawrence H. Uricchio ◽  
Joshua Galanter ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Meta Analysis ◽  
Admixture Mapping ◽  
Asthma Susceptibility

scholarly journals The Heritability of Behavior: A Meta-analysis

2019 ◽  
Vol 110 (4) ◽  
pp. 403-410 ◽  
Author(s):  
Ned A Dochtermann ◽  
Tori Schwab ◽  
Monica Anderson Berdal ◽  
Jeremy Dalos ◽  
Raphaël Royauté
Keyword(s):  
Genetic Variation ◽  
Life History ◽  
Life History Traits ◽  
Meta Analysis ◽  
Behavioral Responses ◽  
Relative Effect ◽  
Biologically Relevant ◽  
Sources Of Variation ◽  
High Heritability ◽  
Relevant Factors

AbstractThe contribution of genetic variation to phenotypes is a central factor in whether and how populations respond to selection. The most common approach to estimating these influences is via the calculation of heritabilities, which summarize the contribution of genetic variation to phenotypic variation. Heritabilities also indicate the relative effect of genetic variation on phenotypes versus that of environmental sources of variation. For labile traits like behavioral responses, life history traits, and physiological responses, estimation of heritabilities is important as these traits are strongly influenced by the environment. Thus, knowing whether or not genetic variation is present within populations is necessary to understand whether or not these populations can evolve in response to selection. Here we report the results of a meta-analysis summarizing what we currently know about the heritability of behavior. Using phylogenetically controlled methods we assessed the average heritability of behavior (0.235)—which is similar to that reported in previous analyses of physiological and life history traits—and examined differences among taxa, behavioral classifications, and other biologically relevant factors. We found that there was considerable variation among behaviors as to how heritable they were, with migratory behaviors being the most heritable. Interestingly, we found no effect of phylogeny on estimates of heritability. These results suggest, first, that behavior may not be particularly unique in the degree to which it is influenced by factors other than genetics and, second, that those factors influencing whether a behavioral trait will have low or high heritability require further consideration.

scholarly journals Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (14) ◽  
pp. 23978-23995 ◽  
Author(s):  
Clara Benna ◽  
Charlotte Helfrich-Förster ◽  
Senthilkumar Rajendran ◽  
Halenya Monticelli ◽  
Pierluigi Pilati ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Cancer Risk ◽  
Clock Genes ◽  
Meta Analysis

scholarly journals The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis

2017 ◽  
Vol 116 (8) ◽  
pp. 1092-1110 ◽  
Author(s):  
P G Vaughan-Shaw ◽  
F O'Sullivan ◽  
S M Farrington ◽  
E Theodoratou ◽  
H Campbell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Genetic Variation ◽  
Meta Analysis ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Cancer Outcome ◽  
The Impact

Genetic variation and systemic lupus erythematosus: A field synopsis and systematic meta-analysis

2018 ◽  
Vol 17 (6) ◽  
pp. 553-566 ◽  
Author(s):  
Dong Yeon Jeong ◽  
Sang Woo Lee ◽  
Young Ha Park ◽  
Ji Hoon Choi ◽  
Young Wook Kwon ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Genetic Variation ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Systemic Lupus

scholarly journals Genetic variation frequencies in Wilms' tumor: A meta‐analysis and systematic review

2016 ◽  
Vol 107 (5) ◽  
pp. 690-699 ◽  
Author(s):  
Changkai Deng ◽  
Rong Dai ◽  
Xuliang Li ◽  
Feng Liu
Keyword(s):  
Systematic Review ◽  
Genetic Variation ◽  
Wilms Tumor ◽  
Meta Analysis

scholarly journals Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Hanneke JM Kerkhof ◽  
Ingrid Meulenbelt ◽  
Andrew Carr ◽  
Antonio Gonzalez ◽  
Deborah Hart ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Genetic Variation ◽  
Meta Analysis ◽  
Estrogen Receptor Beta ◽  
Common Genetic Variation ◽  
Esr2 Gene ◽  
Receptor Beta
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