scholarly journals A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data

2010 ◽  
Vol 10 (4) ◽  
pp. 278-291 ◽  
Author(s):  
J Luo ◽  
M Schumacher ◽  
A Scherer ◽  
D Sanoudou ◽  
D Megherbi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Microarray Gene Expression Data ◽  
Prediction Performance ◽  
Batch Effect ◽  
Expression Data ◽  
Microarray Gene Expression ◽  
Microarray Gene

scholarly journals Batch effect removal methods for microarray gene expression data integration: a survey

2012 ◽  
Vol 14 (4) ◽  
pp. 469-490 ◽  
Author(s):  
C. Lazar ◽  
S. Meganck ◽  
J. Taminau ◽  
D. Steenhoff ◽  
A. Coletta ◽  
...  
Keyword(s):  
Gene Expression ◽  
Data Integration ◽  
Gene Expression Data ◽  
Microarray Gene Expression Data ◽  
Batch Effect ◽  
Expression Data ◽  
Microarray Gene Expression ◽  
Microarray Gene

Cox Survival Analysis of Microarray Gene Expression Data Using Correlation Principal Component Regression

2007 ◽  
Vol 6 (1) ◽  
Author(s):  
Qiang Zhao ◽  
Jianguo Sun
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Principal Component Regression ◽  
Predictive Ability ◽  
Principal Component ◽  
Microarray Gene Expression Data ◽  
Expression Data ◽  
Microarray Gene Expression ◽  
New Approach ◽  
Microarray Gene

Statistical analysis of microarray gene expression data has recently attracted a great deal of attention. One problem of interest is to relate genes to survival outcomes of patients with the purpose of building regression models for the prediction of future patients' survival based on their gene expression data. For this, several authors have discussed the use of the proportional hazards or Cox model after reducing the dimension of the gene expression data. This paper presents a new approach to conduct the Cox survival analysis of microarray gene expression data with the focus on models' predictive ability. The method modifies the correlation principal component regression (Sun, 1995) to handle the censoring problem of survival data. The results based on simulated data and a set of publicly available data on diffuse large B-cell lymphoma show that the proposed method works well in terms of models' robustness and predictive ability in comparison with some existing partial least squares approaches. Also, the new approach is simpler and easy to implement.

Sign in / Sign up

Export Citation Format

Share Document