scholarly journals Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population

2010 ◽  
Vol 11 (4) ◽  
pp. 292-299 ◽  
Author(s):  
M S Nørskov ◽  
R Frikke-Schmidt ◽  
S E Bojesen ◽  
B G Nordestgaard ◽  
S Loft ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
General Population ◽  
Copy Number Variation ◽  
Copy Number ◽  
Glutathione S Transferase ◽  
Corpus Uteri ◽  
Number Variation

scholarly journals Carcinosarcoma of the prostate: case report with molecular and histological characterization

2018 ◽  
Vol 33 (4) ◽  
pp. 540-544 ◽  
Author(s):  
Samanta Salvi ◽  
Valentina Casadio ◽  
Filippo Martignano ◽  
Giorgia Gurioli ◽  
Maria Maddalena Tumedei ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Copy Number Variations ◽  
Molecular Characteristics ◽  
Glutathione S Transferase ◽  
Molecular Alterations ◽  
Positive Expression ◽  
Molecular Pattern ◽  
Programmed Death ◽  
Number Variation

Background: We report a case of prostatic carcinosarcoma, a rare variant of prostatic cancer, which is composed of a mixture of epithelial and mesenchymal components with a generally poor outcome. Aims and methods: We aim to identify molecular alterations, in particular copy number variations of AR and c -MYC genes, methylation and expression of glutathione S-transferase P1 (GSTP1), programmed death-ligand 1 (PD-L1), AR, and phosphorylated AR expression. Results: We found a distinct molecular pattern between adenocarcinoma and carcinosarcoma, which was characterized by high AR copy number variation gain; positive expression of PD-L1, AR, and phosphorylated AR; low espression of GSTP1 in epithelial component. The sarcomatoid component had a lower gain of the AR gene, and no expression of PD-L1, AR, phosphorylated AR, or GSTP1. Both components had a gain of c-MYC copy number variation. Conclusions: Our findings suggest that carcinosarcoma has specific molecular characteristics that could be indicative for early diagnosis and treatment selection.

Increased paternal age and the influence on burden of genomic copy number variation in the general population

2013 ◽  
Vol 132 (4) ◽  
pp. 443-450 ◽  
Author(s):  
Jacobine E. Buizer-Voskamp ◽  
Hylke M. Blauw ◽  
Marco P. M. Boks ◽  
Kristel R. van Eijk ◽  
Jan H. Veldink ◽  
...  
Keyword(s):  
General Population ◽  
Copy Number Variation ◽  
Copy Number ◽  
Paternal Age ◽  
Genomic Copy Number ◽  
Genomic Copy ◽  
Number Variation ◽  
Genomic Copy Number Variation

scholarly journals Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer

2021 ◽  
Vol 22 (8) ◽  
pp. 664-681
Author(s):  
Wenwen Zhong ◽  
Dejuan Wang ◽  
Bing Yao ◽  
Xiaoxia Chen ◽  
Zhongyang Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Copy Number Variation ◽  
Copy Number ◽  
Integrative Analysis ◽  
Number Variation ◽  
Non Coding Rnas

scholarly journals Glutathione S-transferase copy number variation alters lung gene expression

2011 ◽  
Vol 38 (1) ◽  
pp. 15-28 ◽  
Author(s):  
M. W. Butler ◽  
N. R. Hackett ◽  
J. Salit ◽  
Y. Strulovici-Barel ◽  
L. Omberg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copy Number Variation ◽  
Copy Number ◽  
Glutathione S Transferase ◽  
Number Variation

scholarly journals Clinical impact of copy number variation changes in bladder cancer samples

2021 ◽  
Vol 22 (2) ◽  
Author(s):  
Victoria Spasova ◽  
Boris Mladenov ◽  
Simeon Rangelov ◽  
Zora Hammoudeh ◽  
Desislava Nesheva ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Copy Number Variation ◽  
Copy Number ◽  
Clinical Impact ◽  
Number Variation

scholarly journals Association of copy number variation across the genome with neuropsychiatric traits in the general population

2018 ◽  
Vol 177 (5) ◽  
pp. 489-502 ◽  
Author(s):  
Anna L. Guyatt ◽  
Evie Stergiakouli ◽  
Joanna Martin ◽  
James Walters ◽  
Michael O'Donovan ◽  
...  
Keyword(s):  
General Population ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation
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