scholarly journals Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence

2017 ◽  
Vol 7 (7) ◽  
pp. e1163-e1163 ◽  
Author(s):  
J J Prisciandaro ◽  
B K Tolliver ◽  
A P Prescot ◽  
H M Brenner ◽  
P F Renshaw ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence

scholarly journals A Multimethod Examination of Sensitivity to Reward and Sensitivity to Punishment in Bipolar Disorder and Alcohol Dependence: Results from a 2 × 2 Factorial Design

2021 ◽  
Vol 54 (2) ◽  
pp. 70-77
Author(s):  
William Mellick ◽  
James J. Prisciandaro ◽  
Helena Brenner ◽  
Delisa Brown ◽  
Bryan K. Tolliver
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence ◽  
Response Times ◽  
Self Report ◽  
Interactive Effects ◽  
Linear Modeling ◽  
Present Sample ◽  
Sensitivity To Reward ◽  
Self Report Data ◽  
Sensitivity To Punishment

<b><i>Introduction:</i></b> Shared neurobehavioral characteristics of bipolar disorder (BD) and alcohol dependence (AD), including heightened sensitivity to reward (SR), may account for high rates of BD and AD co-occurrence (BD + AD). However, empirical research is lacking. The present multimethod investigation examined SR and sensitivity to punishment (SP) among these patient groups using a reliable and well-validated self-report questionnaire of SR and SP along with a laboratory task specifically designed to distinguish SR and SP activation. <b><i>Methods:</i></b> One-hundred participants formed 4 groups: BD + AD (<i>n</i> = 40), BD (<i>n</i> = 18), AD (<i>n</i> = 25), and healthy controls (<i>n</i> = 17). Clinical interviews were administered, and participants completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSR-Q) and the Point Score Reaction Test behavioral task. Pearson correlations, hierarchical linear regression, and 2 × 2 factorial general linear modeling with Bonferroni-corrected pairwise comparisons were performed. <b><i>Results:</i></b> BD and AD main effects were significant on self-reported SR and SP; however, BD × AD interactions were not. BD + AD individuals were significantly higher on self-reported SR than BD and AD individuals, yet all clinical groups were similar on SP. Behavioral response times did not distinguish groups nor did they associate with self-report data. <b><i>Discussion/Conclusion:</i></b> BD and AD had additive, rather than interactive, effects on self-reported SR and SP. The methods employed, paired with their application to the present sample, may account for a lack of positive findings with behavioral data.

scholarly journals A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset

2020 ◽  
Vol 11 ◽  
Author(s):  
Ulrich W. Preuss ◽  
M. N. Hesselbrock ◽  
V. M. Hesselbrock
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Collaborative Study ◽  
Structured Interviews ◽  
Prospective Comparison ◽  
Bipolar Ii ◽  
Bipolar Patients ◽  
Alcohol Dependent

Objective: Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer studies considered the longitudinal course of alcohol dependence in bipolar subjects and the prospective course of comorbid bipolar II subjects. Beside baseline analysis, longitudinal data of the COGA (Collaborative Study on Genetics in Alcoholism) were used to evaluate the course of bipolar I and II disordered subjects with and without comorbid alcohol dependence over more than 5 years of follow-up.Methods: Characteristics of bipolar disorder, alcohol dependence and comorbid psychiatric disorders were assessed using semi-structured interviews (SSAGA) at baseline and at a 5-year follow-up. Two hundred twenty-eight bipolar I and II patients were subdivided into groups with and without comorbid alcohol dependence.Results: Of the 152 bipolar I and 76 bipolar II patients, 172 (75, 4%) had a comorbid diagnosis of alcohol dependence. Bipolar I patients with alcohol dependence, in particular women, had a more severe course of bipolar disorder, worse social functioning and more suicidal behavior than all other groups of subjects during the 5-year follow-up. In contrast, alcohol dependence improved significantly in both comorbid bipolar I and II individuals during this time.Conclusions: A 5-year prospective evaluation of bipolar patients with and without alcohol dependence confirmed previous investigations suggesting a more severe course of bipolar disorder in comorbid bipolar I individuals, whereas bipolar II individuals were less severely impaired by comorbid alcohol use disorder. While severity of alcohol dependence improved during this time in comorbid alcohol-dependent bipolar I patients, the unfavorable outcome for these individuals might be due to the higher comorbidity with personality and other substance use disorders which, together with alcohol dependence, eventually lead to poorer symptomatic and functional clinical outcomes.

scholarly journals A Randomized, Double-Blind, Placebo-Controlled Trial of Quetiapine in Patients with Bipolar Disorder, Mixed or Depressed Phase, and Alcohol Dependence

2014 ◽  
Vol 38 (7) ◽  
pp. 2113-2118 ◽  
Author(s):  
E. Sherwood Brown ◽  
Domingo Davila ◽  
Alyson Nakamura ◽  
Thomas J. Carmody ◽  
A. John Rush ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo

Zonisamide

2018 ◽  
Author(s):  
Andrea E. Cavanna
Keyword(s):  
Bipolar Disorder ◽  
Weight Gain ◽  
Adverse Effects ◽  
Alcohol Dependence ◽  
Antiepileptic Drug ◽  
Preliminary Evidence ◽  
Tolerability Profile ◽  
Patients With Epilepsy ◽  
Psychiatric Adverse Effects ◽  
Acceptable Tolerability Profile

Zonisamide is a second-generation antiepileptic drug characterized by a few antiepileptic indications, with an acceptable interaction profile in polytherapy. Zonisamide has an acceptable tolerability profile in patients with epilepsy, with depression, irritability, agitation and psychosis as the most commonly reported psychiatric adverse effects. Zonisamide has no approved indications or clinical uses in psychiatry, as initial findings from uncontrolled studies suggesting effectiveness in the treatment of patients with bipolar disorder did not find confirmation. There is preliminary evidence for possible usefulness of zonisamide in the treatment of patients with obesity and psychotropic-associated weight gain, as well as alcohol dependence and withdrawal.

scholarly journals Delay discounting and reward sensitivity in a 2 × 2 study of bipolar disorder and alcohol dependence

Addiction ◽  
2019 ◽  
Vol 114 (8) ◽  
pp. 1369-1378 ◽  
Author(s):  
William Mellick ◽  
Bryan K. Tolliver ◽  
Helena Brenner ◽  
James J. Prisciandaro
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence ◽  
Delay Discounting ◽  
Reward Sensitivity

Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder

2020 ◽  
Vol 261 ◽  
pp. 181-186 ◽  
Author(s):  
Mariela Mosheva ◽  
Alessandro Serretti ◽  
Yelena Stukalin ◽  
Chiara Fabbri ◽  
Michal Hagin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence
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