scholarly journals Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study

2016 ◽  
Vol 6 (2) ◽  
pp. e743-e743 ◽  
Author(s):  
C N Black ◽  
B W J H Penninx ◽  
M Bot ◽  
A O Odegaard ◽  
M D Gross ◽  
...  
2014 ◽  
Vol 27 (3) ◽  
pp. 551-568 ◽  
Author(s):  
Rosalba Hernandez ◽  
Kiarri N. Kershaw ◽  
Thomas R. Prohaska ◽  
Pin-Chieh Wang ◽  
David X. Marquez ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Shouling Wu ◽  
Luli Xu ◽  
Mingyang Wu ◽  
Shuohua Chen ◽  
Youjie Wang ◽  
...  

Abstract Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness. Methods A total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness. Results Multivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29–48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17–0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25–2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose–response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005). Conclusion Participants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.


2018 ◽  
Vol 32 (6) ◽  
pp. 653-671 ◽  
Author(s):  
M. Masselink ◽  
E. Van Roekel ◽  
B.L. Hankin ◽  
L. Keijsers ◽  
G.M.A. Lodder ◽  
...  

Many longitudinal studies have investigated whether self–esteem predicts depressive symptoms (vulnerability model) or the other way around (scar model) in adolescents. The most common method of analysis has been the cross–lagged panel model (CLPM). The CLPM does not separate between–person effects from within–person effects, making it unclear whether the results from previous studies actually reflect the within–person effects or whether they reflect differences between people. We investigated the associations between self–esteem and depressive symptoms at the within–person level, using random intercept cross–lagged panel models (RI–CLPMs). To get an impression of the magnitude of possible differences between the RI–CLPM and the CLPM, we compared the results of both models. We used data from three longitudinal adolescent samples (age range: 7–18 years; study 1: N = 1948; study 2: N = 1455; study 3: N = 316). Intervals between the measurements were 1–1.5 years. Single–paper meta–analyses showed support for small within–person associations from self–esteem to depressive symptoms, but not the other way around, thus only providing some support for the vulnerability model. The cross–lagged associations in the aggregated RI–CLPM and CLPM showed similar effect sizes. Overall, our results show that over 1– to 1.5–year time intervals, low self–esteem may negatively influence depressive symptoms over time within adolescents, but only weakly so. © 2018 The Authors. European Journal of Personality published by John Wiley & Sons Ltd on behalf of European Association of Personality Psychology


2020 ◽  
Vol 11 ◽  
Author(s):  
Ariane Göbel ◽  
Petra Arck ◽  
Kurt Hecher ◽  
Michael Schulte-Markwort ◽  
Anke Diemert ◽  
...  

Background: During the last decades, fathers have increasingly participated in prenatal care, birth preparation classes, and childbirth. However, comparably little is known about the prenatal emotional well-being of fathers, particularly content and extent of broader paternal concerns that may arise during pregnancy beyond those focusing on childbirth. Thus, the aims of this study were to investigate the manifestation of paternal pregnancy-related worries in a population-based sample and to identify relevant associated factors.Materials and Methods: As part of a longitudinal pregnancy cohort at the University Medical Center Hamburg-Eppendorf, Germany, N = 129 expectant fathers were assessed once during pregnancy. Pregnancy-related worries centering around medical procedures, childbirth, health of the baby, as well as socioeconomic aspects were assessed with the Cambridge Worry Scale (CWS). Additionally, paternal socioeconomic background and maternal obstetrical history, symptoms of generalized anxiety and depression, and level of hostility were investigated, as well as perceived social support. The cross-sectional data were analyzed based on multiple regression analyses.Results: The level of reported worries was overall low. Some fathers reported major worries for individual aspects like the health of a significant other (10.9%) and the baby (10.1%), as well as the current financial (6.2%) and employment situation (8.5%). Pregnancy-related worries were negatively associated with household income and positively associated with anxious and depressive symptoms and low perceived social support. Associations varied for specific pregnancy-related worries.Limitations: Due to the cross-sectional data examined in this study, a causal interpretation of the results is not possible. The sample was rather homogeneous regarding its socioeconomic background. More research needs to be done in larger, more heterogeneous samples.Conclusion: Though overall worries were rather low in this sample, specific major worries could be identified. Hence, addressing those fathers reporting major worries regarding specific aspects already in prenatal care might support their psychosocial adjustment. Fathers with little income, those with elevated levels of general anxious and depressive symptoms, and those with less social support reported higher pregnancy-related worries. Our results indicate the relevance of concerns beyond health- and birth-related aspects that could be relevant for fathers. Measurements developed specifically for expectant fathers are needed to properly capture their perspective already during pregnancy.


2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Asuka Hirose ◽  
Masakazu Terauchi ◽  
Mihoko Akiyoshi ◽  
Yoko Owa ◽  
Kiyoko Kato ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhangying Wu ◽  
Xiaomei Zhong ◽  
Qi Peng ◽  
Ben Chen ◽  
Min Zhang ◽  
...  

Objectives: Although previous studies have extensively confirmed the cross-sectional relationship between cognitive impairment and depression in depressed elderly patients, the findings of their longitudinal associations are still mixed. The purpose of this study was to explore the two-way causal relationship between depression symptoms and cognition in patients with late-life depression (LLD).Methods: A total of 90 patients with LLD were assessed across two time points (baseline and 1-year follow up) on measures of 3 aspects of cognition and depressive symptoms. The data were then fitted to a structural equation model to examine two cross-lagged effects.Results: Depressive symptoms predicted a decline in executive function (β = 0.864, p = 0.049) but not vice versa. Moreover, depressive symptoms were predicted by a decline in scores of working memory test (β = −0.406, p = 0.023), respectively. None of the relationships between the two factors was bidirectional.Conclusion: These results provide robust evidence that the relationship between cognition and depressive symptoms is unidirectional. Depressive symptoms may be a risk factor for cognitive decline. The decrease of information processing speed predicts depressive symptoms.


1997 ◽  
Vol 5 (2) ◽  
pp. 131-144 ◽  
Author(s):  
Harold G. Koenig ◽  
Judith C. Hays ◽  
Linda K. George ◽  
Dan G. Blazer ◽  
David B. Larson ◽  
...  

2021 ◽  
pp. 1-25
Author(s):  
Naomi Cano-Ibáñez ◽  
Lluis Serra-Majem ◽  
Sandra Martín-Peláez ◽  
Miguel Ángel Martínez-González ◽  
Jordi Salas-Salvadó ◽  
...  

Abstract The burden of depression is increasing worldwide, specifically in older adults. Unhealthy dietary patterns may partly explain this phenomenon. In the Spanish PREDIMED-Plus study we explored (1) the cross-sectional association between the adherence to the Prime Diet Quality Score- (PDQS), an a priori-defined high-quality food pattern and the prevalence of depressive symptoms at baseline (cross-sectional analysis), and (2) the prospective association of baseline PDQS with changes in depressive symptomatology after 2 years of follow-up. After exclusions, we assessed 6612 participants in the cross-sectional analysis and 5523 participants in the prospective analysis. An energy-adjusted high-quality dietary score (PDQS) was assessed using a validated food-frequency questionnaire (FFQ). The cross-sectional association between PDQS and the prevalence of depression, presence of depressive symptoms and prospectively assessed changes in depressive symptoms was evaluated through multivariable regression models (logistic and linear models and mixed linear-effects models). PDQS was inversely associated with depressive status in the cross-sectional analysis. Participants in the highest quintile of PDQS (Q5) showed a significantly reduced odds of depression prevalence as compared to participants in the lowest quartile of PDQS (Q1) [OR (95%) CI= 0.82 (0.68, 0.98))]. The baseline prevalence of depression decreased across PDQS quintiles (p for trend=0.015). A statistically significant association between PDQS and changes in depressive symptoms after 2-y follow-up was found (β (95%) CI = −0.67 z-score (−1.17, −0.18). A higher PDQS was cross-sectionally related to a lower depressive status. Nevertheless, the null finding in our prospective analysis, raises the possibility of reverse causality. Further prospective investigation is required to ascertain the association between PDQS and changes in depressive symptoms along time.


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