scholarly journals Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations

2016 ◽  
Vol 6 (3) ◽  
pp. e754-e754 ◽  
Author(s):  
T Yamamura ◽  
Y Okamoto ◽  
G Okada ◽  
Y Takaishi ◽  
M Takamura ◽  
...  
Keyword(s):  
Major Depression ◽  
Early Treatment ◽  
Resting State ◽  
Low Frequency ◽  
Poor Response ◽  
Resting State Fmri ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Fmri Study ◽  
Resistant Depression

scholarly journals Decreased Interhemispheric Coordination in Treatment-Resistant Depression: A Resting-State fMRI Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71368 ◽  
Author(s):  
Wenbin Guo ◽  
Feng Liu ◽  
Zhimin Xue ◽  
Keming Gao ◽  
Zhening Liu ◽  
...  
Keyword(s):  
Resting State ◽  
Resting State Fmri ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Fmri Study ◽  
Resistant Depression

scholarly journals A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Jenifer A. Murphy ◽  
Jerome Sarris ◽  
Gerard J. Byrne
Keyword(s):  
Major Depression ◽  
Poor Response ◽  
Clinical Problem ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Rank One ◽  
System Activation ◽  
Resistant Depression ◽  
Staging Model ◽  
Inflammatory System

Major depression does not always remit. Difficult-to-treat depression is thought to contribute to the large disease burden posed by depression. Treatment-resistant depression (TRD) is the conventional term for nonresponse to treatment in individuals with major depression. Indicators of the phenomenon are the poor response rates to antidepressants in clinical practice and the overestimation of the efficacy of antidepressants in medical scientific literature. Current TRD staging models are based on anecdotal evidence without an empirical rationale to rank one treatment strategy above another. Many factors have been associated with TRD such as inflammatory system activation, abnormal neural activity, neurotransmitter dysfunction, melancholic clinical features, bipolarity, and a higher traumatic load. This narrative review provides an overview of this complex clinical problem and discusses the reconceptualization of depression using an illness staging model in line with other medical fields such as oncology.

scholarly journals Animal models of major depression: drawbacks and challenges

2019 ◽  
Vol 126 (11) ◽  
pp. 1383-1408 ◽  
Author(s):  
Barbara Planchez ◽  
Alexandre Surget ◽  
Catherine Belzung
Keyword(s):  
Major Depression ◽  
Animal Models ◽  
Poor Response ◽  
Treatment Resistant Depression ◽  
Recurrent Depression ◽  
Treatment Resistant ◽  
Neuronal Populations ◽  
Future Challenges ◽  
Resistant Depression ◽  
Depression Subtypes

Abstract Major depression is a leading contributor to the global burden of disease. This situation is mainly related to the chronicity and/or recurrence of the disorder, and to poor response to antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating the environment to which rodents are exposed (during the developmental period or adulthood) or biological underpinnings (i.e. gene deletion or overexpression of candidate genes, targeted lesions of brain areas, optogenetic control of specific neuronal populations, etc.). These manipulations can alter specific behavioural and biological outcomes that can be related to different symptomatic and pathophysiological dimensions of major depression. However, animal models of major depression display substantial shortcomings that contribute to the lack of innovative pharmacological approaches in recent decades and which hamper our capabilities to investigate treatment-resistant depression. Here, we discuss the validity of these models, review putative models of treatment-resistant depression, major depression subtypes and recurrent depression. Furthermore, we identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical approaches to depression.

T121. Increased Resting State fMRI Entropy Associated With Clinical Response to Ketamine for Treatment Resistant Depression in Adolescents

2018 ◽  
Vol 83 (9) ◽  
pp. S175 ◽  
Author(s):  
Abhrajeet Roy ◽  
Bryon Mueller ◽  
Bonnie Klimes-Dougan ◽  
Mindy Schreiner ◽  
Michelle Thai ◽  
...  
Keyword(s):  
Clinical Response ◽  
Resting State ◽  
Resting State Fmri ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

Functional abnormalities in Broca’s area in adolescents with ADHD: A resting-state fMRI study

2015 ◽  
Vol 51 (1) ◽  
Author(s):  
Michał Pikusa ◽  
Rafał Jończyk
Keyword(s):  
Resting State ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Broca’S Area ◽  
Broca's Area ◽  
Hyperactivity Disorder ◽  
Spontaneous Neural Activity ◽  
Fmri Study ◽  
Brodmann Areas ◽  
Underlying Causes

AbstractThere is evidence that attention-deficit/hyperactivity disorder (ADHD) is associated with linguistic difficulties. However, the pathophysiology underlying these difficulties is yet to be determined. This study investigates functional abnormalities in Broca’s area, which is associated with speech production and processing, in adolescents with ADHD by means of resting-state fMRI. Data for the study was taken from the ADHD-200 project and included 267 ADHD patients (109 with combined inattentive/hyperactive subtype and 158 with inattentive subtype) and 478 typically-developing control (TDC) subjects. An analysis of fractional amplitude of low-frequency fluctuations (fALFF), which reflects spontaneous neural activity, in Broca’s area (Brodmann Areas 44/45) was performed on the data and the results were compared statistically across the participant groups. fALFF was found to be significantly lower in the ADHD inattentive group as compared to TDC in BA 44, and in the ADHD combined group as compared to TDC in BA 45. The results suggest that there are functional abnormalities in Broca’s area with people suffering from ADHD, and that the localization of these abnormalities might be connected to particular language deficits associated with ADHD subtypes, which we discuss in the article. The findings might help explore the underlying causes of specific language difficulties in ADHD.

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