scholarly journals Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index

2015 ◽  
Vol 5 (6) ◽  
pp. e592-e592 ◽  
Author(s):  
T-K Clarke ◽  
L S Hall ◽  
A M Fernandez-Pujals ◽  
D J MacIntyre ◽  
P Thomson ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Psychological Distress ◽  
Depressive Disorder ◽  
Body Mass ◽  
Major Depressive ◽  
Polygenic Risk ◽  
Current Psychological

Physical exercise and body mass index as correlates of major depressive disorder in community-dwelling adults: Results from the PISMA-ep study

2019 ◽  
Vol 251 ◽  
pp. 263-269 ◽  
Author(s):  
Alejandro Porras-Segovia ◽  
Margarita Rivera ◽  
Esther Molina ◽  
David López-Chaves ◽  
Blanca Gutiérrez ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Physical Exercise ◽  
Depressive Disorder ◽  
Body Mass ◽  
Community Dwelling ◽  
Major Depressive

Body Mass Index and Variability in Hippocampal Volume in Youth With Major Depressive Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S257
Author(s):  
Sneha Chenji ◽  
Emily Cox ◽  
Natalia Jaworska ◽  
Rose Swansburg ◽  
Frank MacMaster
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Body Mass ◽  
Hippocampal Volume ◽  
Major Depressive

scholarly journals Body Mass Index as a Moderator of Treatment Response to Ketamine for Major Depressive Disorder

2020 ◽  
Vol 40 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Marlene P. Freeman ◽  
Rebecca S. Hock ◽  
George I. Papakostas ◽  
Heidi Judge ◽  
Cristina Cusin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Treatment Response ◽  
Body Mass ◽  
Major Depressive

Body mass index (BMI) in major depressive disorder and its effects on depressive symptomatology and antidepressant response

2019 ◽  
Vol 256 ◽  
pp. 524-531 ◽  
Author(s):  
Nadine Dreimüller ◽  
Klaus Lieb ◽  
André Tadić ◽  
Jan Engelmann ◽  
Daniel Wollschläger ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Body Mass ◽  
Depressive Symptomatology ◽  
Antidepressant Response ◽  
Major Depressive

scholarly journals Dissection of Major Depressive Disorder using polygenic risk scores for Schizophrenia in two independent cohort

2016 ◽  
Author(s):  
HC Whalley ◽  
MJ Adams ◽  
LS Hall ◽  
T-K Clarke ◽  
AM Fernandez-Pujals ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Psychological Distress ◽  
Depressive Disorder ◽  
Genetic Risk ◽  
Large Population ◽  
Case Control ◽  
Risk Scores ◽  
Uk Biobank ◽  
Major Depressive ◽  
Polygenic Risk

AbstractMajor depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterised by low mood, psychomotor slowing, and increased levels of the personality trait neuroticism; factors which are also associated with schizophrenia (SCZ). It is possible that some cases of MDD may have a substantial genetic loading for SCZ. A sign of the presence of SCZ-like MDD sub-groups would be indicated by an interaction between MDD status and polygenic risk of SCZ on cognitive, personality and mood measures. In the current study, we hypothesised that higher SCZ-polygenic risk would define larger MDD case-control differences in cognitive ability, and smaller differences in distress and neuroticism. Polygenic risk scores (PGRS) for SCZ and their association with cognitive variables, neuroticism, mood, and psychological distress were estimated in a large population-based cohort (Generation Scotland: Scottish Family Health Study, GS:SFHS). Individuals were divided into those with, and without, depression (n=2587 & n=16,764 respectively) to test whether there was an interaction between MDD status and schizophrenia risk. Replication was sought in UK Biobank (n=33,525). In both GS:SFHS and UK Biobank we found significant interactions between SCZ-PGRS and MDD status for measures of psychological distress and neuroticism. In both cohorts there was a reduction of case-control differences on a background of higher genetic risk of SCZ. These findings suggest that depression on a background of high genetic risk for SCZ may show attenuated associations with distress and neuroticism. This may represent a causally distinct form of MDD more closely related to SCZ.

scholarly journals Body mass index, but not FTO genotype or major depressive disorder, influences brain structure

Neuroscience ◽  
2013 ◽  
Vol 252 ◽  
pp. 109-117 ◽  
Author(s):  
J.H. Cole ◽  
C.P. Boyle ◽  
A. Simmons ◽  
S. Cohen-Woods ◽  
M. Rivera ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Body Mass ◽  
Brain Structure ◽  
Major Depressive

Body mass index and variability in hippocampal volume in youth with major depressive disorder

2021 ◽  
Vol 282 ◽  
pp. 415-425
Author(s):  
Sneha Chenji ◽  
Emily Cox ◽  
Natalia Jaworska ◽  
Rose M. Swansburg ◽  
Frank P. MacMaster
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Body Mass ◽  
Hippocampal Volume ◽  
Major Depressive
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