scholarly journals Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression

2015 ◽  
Vol 5 (6) ◽  
pp. e578-e578 ◽  
Author(s):  
A Papadopoulou ◽  
T Siamatras ◽  
R Delgado-Morales ◽  
N D Amin ◽  
V Shukla ◽  
...  
Keyword(s):  
Major Depression ◽  
Chronic Stress ◽  
Mouse Brain ◽  
Cyclin Dependent Kinase ◽  
Acute And Chronic Stress ◽  
Cyclin Dependent Kinase 5

scholarly journals Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications

2013 ◽  
Vol 16 (3) ◽  
pp. 683-689 ◽  
Author(s):  
Alfredo Ramos-Miguel ◽  
J. Javier Meana ◽  
Jesús A. García-Sevilla
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Psychotropic Drugs ◽  
Psychotropic Medications ◽  
Urine Samples ◽  
Post Mortem ◽  
Cyclin Dependent Kinase ◽  
Functional Interaction ◽  
Syntaxin 1A ◽  
Cyclin Dependent Kinase 5

AbstractCyclin-dependent kinase-5 (CDK5) and p35/p25 activators, interacting with the exocytotic machinery (e.g. munc18-1 and syntaxin-1A), play critical roles in neurosecretion. The basal status of CDK5/p35/p25 and the effect of psychotropic drugs (detected in blood/urine samples) were investigated in post-mortem prefrontal cortex (PFC)/Brodmann's area 9 of schizophrenia (SZ) and major depression (MD) subjects. In SZ (all subjects, n = 24), CDK5 and p35, but not p25, were reduced (−28 to −58%) compared to controls. In SZ antipsychotic-free (n = 12), activator p35 was decreased (−52%). In SZ antipsychotic-treated (n = 12), marked reductions of CDK5 (−47%), p35 (−76%) and p25 (−36%) were quantified. In MD (n = 13), including antidepressant-free/treated subgroups, CDK5, p35 and p25 were unaltered. In SZ (n = 24), CDK5, p35 or p25 correlated with munc18-1a, but not with syntaxin-1A. The results demonstrate reduced p35 basal content and down-regulation of CDK5/p35/p25 by antipsychotics in SZ. The suggested CDK5/munc18-1a functional interaction may lead to dysregulated neurosecretion in SZ PFC.

scholarly journals Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain

2014 ◽  
Vol 26 (3) ◽  
pp. 967-976 ◽  
Author(s):  
Naoki Mita ◽  
Xiaojuan He ◽  
Kodai Sasamoto ◽  
Tomohide Mishiba ◽  
Toshio Ohshima
Keyword(s):  
Cortical Neuron ◽  
Mouse Brain ◽  
Dendritic Spine ◽  
Cyclin Dependent Kinase ◽  
Spine Formation ◽  
Cyclin Dependent Kinase 5

Hypoxic preconditioning reduces expression of the cyclin dependent kinase 5 in the post-ischemic neurons

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S309-S309
Author(s):  
Svetlana Pundik ◽  
W David Lust ◽  
Jose Valerio ◽  
Michael Buczek ◽  
Randall D York ◽  
...  
Keyword(s):  
Hypoxic Preconditioning ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase 5

Homology Modeling of Mus Musculus CDK5 and Molecular Docking Studies with Flavonoids

2017 ◽  
Vol 9 (6) ◽  
Author(s):  
Sowmya Suri ◽  
Rumana Waseem ◽  
Seshagiri Bandi ◽  
Sania Shaik
Keyword(s):  
Molecular Docking ◽  
3D Model ◽  
Structural Features ◽  
Docking Studies ◽  
Amino Acid Residues ◽  
Cyclin Dependent Kinase ◽  
Ligand Complex ◽  
Ligand Interaction ◽  
Molecular Docking Studies ◽  
Cyclin Dependent Kinase 5

A 3D model of Cyclin-dependent kinase 5 (CDK5) (Accession Number: Q543f6) is generated based on crystal structure of P. falciparum PFPK5-indirubin-5-sulphonate ligand complex (PDB ID: 1V0O) at 2.30 Å resolution was used as template. Protein-ligand interaction studies were performed with flavonoids to explore structural features and binding mechanism of flavonoids as CDK5 (Cyclin-dependent kinase 5) inhibitors. The modelled structure was selected on the basis of least modeler objective function. The model was validated by PROCHECK. The predicted 3D model is reliable with 93.0% of amino acid residues in core region of the Ramachandran plot. Molecular docking studies with flavonoids viz., Diosmetin, Eriodictyol, Fortuneletin, Apigenin, Ayanin, Baicalein, Chrysoeriol and Chrysosplenol-D with modelled protein indicate that Diosmetin is the best inhibitor containing docking score of -8.23 kcal/mol. Cys83, Lys89, Asp84. The compound Diosmetin shows interactions with Cys83, Lys89, and Asp84.

An intervention study on the effectiveness of an anti-stress-app on psychophysiological acute and chronic stress (Preprint)

2018 ◽  
Author(s):  
Franziska Lautenbach
Keyword(s):  
Chronic Stress ◽  
Acute Stress ◽  
Physiological Stress ◽  
Stress Test ◽  
Experimental Studies ◽  
Trier Social Stress Test ◽  
Control Group ◽  
Subjective Perception ◽  
Face To Face ◽  
Acute And Chronic Stress

BACKGROUND Dealing with stress is of central importance. Lately, smartphone applications (apps) are deployed in stress interventions as they offer maximal flexibility for users. First results of experimental studies show that anti-stress apps effect subjective perception of stress positively (Ly et al., 2014). However, current literature lacks studies on physiological stress reactions (e.g., cortisol), although they are of special interest to health issues. OBJECTIVE Therefore, the aim of this study was to investigate the effectiveness of an anti-stress app in chronic and acute stress reduction on a physiological (cortisol) and psychological level (subjective perception of stress) in comparison to a face-to-face and a control group in a pre-post design, for the first time. METHODS Sixty-two participants took part in the pretesting procedure (drop-out of 53 %). Based on age, gender, physical activity and subjectively perceived acute stress due to the Trier Social Stress Test for groups (TSST-G; von Dawans et al., 2011) as well as based on subjectively chronic stress assessed during the pretest, participants were parallelized in three groups (anti-stress-app: n = 10, face-to-face: n = 11, control group: n = 9). RESULTS After six weeks of the cognitive-based resource-oriented intervention, participants were exposed to the TSST-G for post testing. Results did not show a change of cortisol secretion or cognitive appraisal of the acute stressor. Further, no changes were detected in the chronic physiological stress reaction. CONCLUSIONS Possible causes are discussed extensively. CLINICALTRIAL no

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