scholarly journals Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

2015 ◽  
Vol 5 (11) ◽  
pp. e683-e683 ◽  
Author(s):  
J W Hwang ◽  
N Egorova ◽  
X Q Yang ◽  
W Y Zhang ◽  
J Chen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Control ◽  
Resting State ◽  
Control Network ◽  
Subthreshold Depression ◽  
Resting State Functional Connectivity ◽  
Cognitive Control Network

scholarly journals White matter hyperintensity-associated structural disconnection, resting state functional connectivity, and cognitive control in older adults

2020 ◽  
Author(s):  
Abhishek Jaywant ◽  
Katharine Dunlop ◽  
Lindsay W. Victoria ◽  
Lauren Oberlin ◽  
Charles Lynch ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Functional Connectivity ◽  
Cognitive Control ◽  
Resting State ◽  
Structural Connectivity ◽  
Control Network ◽  
Cognitive Inhibition ◽  
Resting State Functional Connectivity ◽  
Cognitive Control Network

AbstractWhite matter hyperintensities (WMH) are linked to cognitive control; however, the structural and functional mechanisms are largely unknown. We investigated the relationship between WMH-associated disruptions of structural connectivity, resting state functional connectivity (RSFC), and cognitive control in older adults. Fifty-eight cognitively-healthy older adults completed cognitive control tasks, structural MRI, and resting state fMRI scans. We estimated inferred, WMH-related disruptions in structural connectivity between pairs of subcortical and cortical regions by overlaying each participant’s WMH mask on a normative tractogram dataset. For region-pairs in which structural disconnection was associated with cognitive control, we calculated RSFC between nodes in those same regions. WMH-related structural disconnection and RSFC in the cognitive control network and default mode network were both associated with poorer cognitive inhibition. These regionally-specific, WMH-related structural and functional changes were more strongly associated with cognitive inhibition compared to standard rating of WMH burden. Our findings highlight the role of circuit-level disruptions to the cognitive control network and default mode network that are related to WMH and impact cognitive control in aging.

scholarly journals A digital intervention targeting cognitive control network dysfunction in middle age and older adults with major depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Faith M. Gunning ◽  
Joaquin A. Anguera ◽  
Lindsay W. Victoria ◽  
Patricia A. Areán
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Cognitive Control ◽  
Video Game ◽  
Resting State ◽  
Rating Scale ◽  
Mechanistic Study ◽  
Control Network ◽  
Middle Aged ◽  
Cognitive Control Network

AbstractNonpharmacological interventions targeting putative network mechanisms of major depressive disorder (MDD) may represent novel treatments. This mechanistic study investigates how a video game-like intervention, designed to improve cognitive control network (CCN) functioning by targeting multitasking, influences the CCN of middle-aged and older adults with MDD. The sample consisted of 34 adults aged 45–75 with SCID-defined diagnosis of MDD, Hamilton depression rating scale scores ≥20, and a deficit in cognitive control. Participants were instructed to play at home for 20–25 min per day, at least 5 times per week, for 4 weeks. Evidence of target engagement was defined a priori as >2/3 of participants showing CCN improvement. CCN engagement was defined as a change in a Z score of ≥0.5 on functional magnetic resonance imaging (fMRI) in activation and functional connectivity of the CCN during task-based and resting-state fMRI, respectively. 74% of participants showed a change in activation of the CCN, and 72% showed an increase in resting-state functional connectivity. Sixty-eight percent demonstrated improved cognitive control function, measured as either improvement on sustained attention or working memory performance or reduced self-reported symptoms of apathy on the frontal systems behavioral scale (FrsBe). Participants also reported a significant reduction in mood symptoms measured by PHQ-9. A remotely deployed neuroscience-informed video game-like intervention improves both CCN functions and mood in middle-aged and older adults with MDD. This easily-disseminated intervention may rescue CCN dysfunction present in a substantial subset of middle-aged and older adults with MDD.

scholarly journals Mindfulness Meditation Training and Executive Control Network Resting State Functional Connectivity

2017 ◽  
Vol 79 (6) ◽  
pp. 674-683 ◽  
Author(s):  
Adrienne A. Taren ◽  
Peter J. Gianaros ◽  
Carol M. Greco ◽  
Emily K. Lindsay ◽  
April Fairgrieve ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Executive Control ◽  
Resting State ◽  
Mindfulness Meditation ◽  
Control Network ◽  
Resting State Functional Connectivity ◽  
Executive Control Network

scholarly journals Impaired left amygdala resting state functional connectivity in subthreshold depression individuals

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaoling Peng ◽  
Way K. W. Lau ◽  
Chanyu Wang ◽  
Lingfang Ning ◽  
Ruibin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Functional Connectivity ◽  
Resting State ◽  
Emotion Processing ◽  
Subthreshold Depression ◽  
Healthy Controls ◽  
Imaging Data ◽  
Resting State Functional Connectivity ◽  
Pathophysiological Mechanisms ◽  
Wide Range

Abstract Subthreshold depression (StD) affects people who experience clinically relevant depressive symptoms, which does not meet the diagnostic criteria for major depressive disorder (MDD). StD represents an ideal model for understanding the pathophysiological mechanisms of depression. Impaired emotion processing is a core feature of depression; careful investigation is required to better understand the neural correlates of emotion processing in depressed populations. In the current study, we explored whether the resting-state functional connectivity of the amygdala, a hub that taps a wide range of brain areas involved in emotion processing, is altered in individuals with StD when compared with healthy controls. Resting-state imaging data was collected from 59 individuals with StD and 59 age- and gender-matched controls. We found that the resting-state functional connectivity of the left amygdala with the cognitive control network and the left insula was significantly lower in people with StD than that in healthy controls. Such association was not observed in the right amygdala. Furthermore, functional connectivity strength between the left amygdala and the left precuneus was positively associated with depressive symptoms in individuals with StD. Our findings are in line with those reported in subjects with MDD, which may assist in further elucidating the pathophysiological mechanisms of depression, and contribute to the development of tailored treatments for individuals with StD who are at high risk of developing MDD.

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