scholarly journals Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids

2015 ◽  
Vol 5 (1) ◽  
pp. e495-e495 ◽  
Author(s):  
G P Amminger ◽  
A Mechelli ◽  
S Rice ◽  
S-W Kim ◽  
C M Klier ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
Young People ◽  
Treatment Response ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Ultra High Risk ◽  
Long Chain

The NEURAPRO Biomarker Analysis: Long-Chain Omega-3 Fatty Acids Improve 6-Month and 12-Month Outcomes in Youth at Ultra-High Risk for Psychosis

2019 ◽  
Author(s):  
G. Paul Amminger ◽  
Barnaby Nelson ◽  
Connie Markulev ◽  
Hok Pan Yuen ◽  
Miriam R. Schäfer ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Biomarker Analysis ◽  
Ultra High Risk ◽  
Long Chain

The NEURAPRO Biomarker Analysis: Long-Chain Omega-3 Fatty Acids Improve 6-Month and 12-Month Outcomes in Youths at Ultra-High Risk for Psychosis

2020 ◽  
Vol 87 (3) ◽  
pp. 243-252 ◽  
Author(s):  
G. Paul Amminger ◽  
Barnaby Nelson ◽  
Connie Markulev ◽  
Hok Pan Yuen ◽  
Miriam R. Schäfer ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Biomarker Analysis ◽  
Ultra High Risk ◽  
Long Chain

scholarly journals Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

2020 ◽  
Author(s):  
Alison McLaverty ◽  
Kelly A. Allott ◽  
Maximus Berger ◽  
Rob Hester ◽  
Patrick D. McGorry ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
Young People ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Ultra High Risk

scholarly journals 210. NEURAPRO: A Multi-center RCT of Omega-3 Polyunsaturated Fatty Acids Versus Placebo in Young People at Ultra-High Risk of Psychotic Disorders: Medium-Term Outcome

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S107-S107 ◽  
Author(s):  
Barnaby Nelson ◽  
G. Paul Amminger ◽  
Connie Markulev ◽  
Hok Pan Yuen ◽  
Suzie Lavoie ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
Young People ◽  
Polyunsaturated Fatty Acids ◽  
Psychotic Disorders ◽  
Omega 3 ◽  
Medium Term ◽  
Term Outcome ◽  
Ultra High Risk

Fatty acid metabolism and the onset of psychotic disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 2089-2089 ◽  
Author(s):  
P. Amminger ◽  
N. Mossaheb ◽  
M. Schlögelhofer ◽  
M. Schäfer
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
Psychotic Disorder ◽  
Controlled Trial ◽  
Psychotic Symptoms ◽  
Omega 3 ◽  
Bioactive Lipids ◽  
Ultra High Risk ◽  
Second Messenger Pathways ◽  
Long Chain

IntroductionPotentially chronic diseases often have a critical point in their course beyond which treatment becomes less effective. In support of this, early treatment in schizophrenia and other psychoses has been linked to better outcome.ObjectivesThe emergence of simultaneous brain volume changes in those ultra-high-risk individuals who develop psychosis indicate an active biological process, and underline the importance of pre-onset treatment. However, pre-psychotic intervention has also been questioned as, using current criteria, only 20–50% of individuals classified as prodromal develop a psychotic disorder within a 1–2 years period.AimsTreatment agents in the pre-psychotic phase should, therefore, not have major side effects. Bioactive lipids are molecules that have both intra- and intercellular roles, including mediation, modulation and control of neurobiological processes, such as ion channel and receptor activity, neurotransmitter release, synaptic plasticity, second messenger pathways and neuronal gene expression.MethodsLong-chain omega-3 polyunsaturated fatty acids (PUFAs) have been shown effective for both, mood and psychotic symptoms, and they have neuroprotective properties. Because of the controversy concerned with the extent to which an intervention may produce harm which outweighs its benefits, omega-3 PUFAs are prime candidates for evaluation in putatively prodromal individuals.ResultsWe report on the first randomized, placebo-controlled trial on the preventive use of omega-3 fatty acids in 81 ultra-high-risk individuals.ConclusionsSupplementation with long-chain omega-3 PUFAs reduces the risk of progression to psychotic disorder, and offers a safe and efficacious strategy for indicated prevention in individuals at ultra-high-risk of developing a psychotic illness.

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