scholarly journals Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism

2013 ◽  
Vol 3 (9) ◽  
pp. e299-e299 ◽  
Author(s):  
F Gu ◽  
V Chauhan ◽  
K Kaur ◽  
W T Brown ◽  
G LaFauci ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Electron Transport ◽  
Frontal Cortex ◽  
Pyruvate Dehydrogenase ◽  
Copy Number ◽  
Electron Transport Chain ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number ◽  
Chain Complexes ◽  
Transport Chain

Abstract 751: Lung mitochondrial DNA copy number variations: E-cig users, smokers, and never-smokers

2021 ◽  
Author(s):  
Kellie M. Mori ◽  
Joseph P. McElroy ◽  
Daniel Y. Weng ◽  
Sangwoon Chung ◽  
Sarah A. Reisinger ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Copy Number ◽  
Copy Number Variations ◽  
Dna Copy Number ◽  
Dna Copy Number Variations ◽  
Mitochondrial Dna Copy Number ◽  
Never Smokers

Rare instances of non-random dropout with the monochrome multiplex qPCR assay for mitochondrial DNA copy number

2021 ◽  
Author(s):  
Stephanie Y Yang ◽  
Charles E Newcomb ◽  
Stephanie L Battle ◽  
Anthony YY Hsieh ◽  
Hailey L Chapman ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Copy Number ◽  
Whole Genome Sequencing Data ◽  
Whole Genome ◽  
Dna Copy Number ◽  
Loop Primer ◽  
Mitochondrial Dna Copy Number ◽  
D Loop

Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and has been of increasing interest to the mitochondrial research community. There are several ways to measure mtDNA-CN, ranging from whole genome sequencing to qPCR. A recent article from the Journal of Molecular Diagnostics described a novel method for measuring mtDNA-CN that is both inexpensive and reproducible. However, we show that certain individuals, particularly those with very low qPCR mtDNA measurements, show poor concordance between qPCR and whole genome sequencing measurements. After examining whole genome sequencing data, this seems to be due to polymorphisms within the D-loop primer region. Non-concordant mtDNA-CN was observed in all instances of polymorphisms at certain positions in the D-loop primer regions, however, not all positions are susceptible to this effect. In particular, these polymorphisms appear disproportionately in individuals with the L, T, and U mitochondrial haplogroups, indicating non-random dropout.

scholarly journals Associations of urinary phthalate metabolites and lipid peroxidation with sperm mitochondrial DNA copy number and deletions

2018 ◽  
Vol 163 ◽  
pp. 10-15 ◽  
Author(s):  
Alexandra M. Huffman ◽  
Haotian Wu ◽  
Allyson Rosati ◽  
Tayyab Rahil ◽  
Cynthia K. Sites ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Dna Copy Number ◽  
Phthalate Metabolites ◽  
Mitochondrial Dna Copy Number
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