scholarly journals Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder

2012 ◽  
Vol 2 (11) ◽  
pp. e184-e184 ◽  
Author(s):  
P H Lee ◽  
R H Perlis ◽  
J-Y Jung ◽  
E M Byrne ◽  
E Rueckert ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Synaptic Transmission ◽  
Association Analysis ◽  
Genome Wide Association ◽  
Major Depressive ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
Glutamatergic Synaptic Transmission

scholarly journals Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects

2008 ◽  
Vol 16 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Dorret I Boomsma ◽  
Gonneke Willemsen ◽  
Patrick F Sullivan ◽  
Peter Heutink ◽  
Piet Meijer ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Major Depression ◽  
Depressive Disorder ◽  
Genome Wide Association ◽  
Major Depressive ◽  
Genome Wide

scholarly journals Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

2017 ◽  
Vol 7 (11) ◽  
Author(s):  
David M. Howard ◽  
Lynsey S. Hall ◽  
Jonathan D. Hafferty ◽  
Yanni Zeng ◽  
Mark J. Adams ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Association Analysis ◽  
Uk Biobank ◽  
Major Depressive ◽  
Genome Wide ◽  
Generation Scotland

scholarly journals Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

2017 ◽  
Vol 20 (4) ◽  
pp. 267-270 ◽  
Author(s):  
Hamdi Mbarek ◽  
Yuri Milaneschi ◽  
Jouke-Jan Hottenga ◽  
Lannie Ligthart ◽  
Eco J. C. de Geus ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Genome Wide Association Study ◽  
Major Depressive ◽  
Significance Level ◽  
Functional Studies ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Significance

In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10−8) and gene-based (p = 1.48 × 10−7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.

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