scholarly journals The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: an experimental study in the monkey

2012 ◽  
Vol 2 (9) ◽  
pp. e161-e161 ◽  
Author(s):  
J Y Rotge ◽  
B Aouizerate ◽  
V Amestoy ◽  
V Lambrecq ◽  
N Langbour ◽  
...  
Keyword(s):  
Experimental Study ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Limbic Thalamus

scholarly journals Effects of rumination on unwanted intrusive thoughts: A replication and extension

2020 ◽  
Vol 11 (1) ◽  
pp. 204380872091258 ◽  
Author(s):  
Martin Kollárik ◽  
Marcel van den Hout ◽  
Carlotta V. Heinzel ◽  
Patrizia D. Hofer ◽  
Roselind Lieb ◽  
...  
Keyword(s):  
Experimental Study ◽  
Obsessive Compulsive Disorder ◽  
Negative Mood ◽  
Intrusive Thoughts ◽  
Intrusive Thought ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Car Accident ◽  
Previous Experimental Study

Studies indicate that rumination might play a role in obsessive–compulsive disorder. In a previous experimental study, rumination about an unwanted intrusive thought (UIT) maintained the urge to neutralize this thought. We sought to replicate and extend these findings with measures of behavioral and mental neutralizing. Additionally, we investigated possible mechanisms that might be involved in the effects of rumination on the UIT. We activated a UIT by asking students ( N = 105) to write down a sentence stating that they wished a loved person would die in a car accident. Participants were randomly allocated to rumination about the UIT, rumination about negative mood, or distraction. As predicted, rumination about the UIT maintained the urge to neutralize the UIT, relative to rumination about negative mood and distraction. In addition, rumination about the UIT also maintained distress associated with the UIT compared to rumination about negative mood and distraction. The effects of rumination did not extend to behavioral or mental neutralizing. UIT frequency and vividness were unaffected by rumination. The present findings strengthen the confidence that rumination contributes to the maintenance of UITs.

scholarly journals The Therapeutic Effect of Electroconvulsive Therapy in Obsessive-Compulsive Disorder Patients: A Quasi-Experimental Study

2021 ◽  
Vol 0 (0) ◽  
pp. 1-23
Author(s):  
Seyed Gholamreza Noorazar ◽  
◽  
Somayyeh Emamizad ◽  
Ali Fakhari-Dehkharghani ◽  
◽  
...  
Keyword(s):  
Experimental Study ◽  
Psychiatric Disorders ◽  
Obsessive Compulsive Disorder ◽  
Electroconvulsive Therapy ◽  
P Value ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Comorbid Psychiatric Disorders ◽  
Quasi Experimental

Background: Electroconvulsive therapy (ECT) is demonstrated to be an effective treatment in some psychiatric disorders. It is postulated ECT should primarily be considered for patients with treatment-resistant obsessive-compulsive disorder (OCD) in the context of major depression. Therefore, we aimed to evaluate the efficacy of ECT in OCD patients without comorbid psychiatric disorders. Methods: This quasi-experimental study was conducted on 12 adult patients with severe OCD (Yale-Brown test score above 25) and no comorbid psychiatric disorders referred to a tertiary care hospital for psychiatric disorders. Treatment was administered three times a week for up to three to four weeks (a minimum of 8 sessions and a maximum of 12 sessions). We completed the Yale-Brown test for all the patients exactly before ECT, on the exact day after applying ECT, and two months after the final ECT session in order to evaluate the effect of therapy. Results: Yale-Brown score of patients significantly decreased after the ECT sessions from 28.08 ± 2.50 to 17.17 ± 3.78 (P-value, 0.043). After treatment, the severity of OCD improved in all patients and reduced to mild and moderate levels in 4 (33.3%) and 8 (66.7%) patients, respectively. After two months the mean Yale-Brown score slightly increased to 18.08 ±1.62 (P-value, 0.125) and the severity of OCD in all 12 patients (100%) became moderate. Nevertheless, in none of them, the Yale-Brown score increased up to the baseline value in this period. None of the patients developed significant side effects during/after ECT sessions. Conclusion: ECT was a safe and effective therapeutic strategy for patients with treatment-resistant OCD with no comorbid psychiatric disorders in our study. However, further randomized controlled trials are required to validate the efficacy of ECT for OCD treatment before implementing it into routine clinical practice.

An experimental study of prospective memory in obsessive-compulsive disorder

2010 ◽  
Vol 33 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Mihály Racsmány ◽  
Gyula Demeter ◽  
Katalin Csigó ◽  
András Harsányi ◽  
Attila Németh
Keyword(s):  
Experimental Study ◽  
Obsessive Compulsive Disorder ◽  
Prospective Memory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
Sign in / Sign up

Export Citation Format

Share Document