scholarly journals Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

2012 ◽  
Vol 2 (11) ◽  
pp. e196-e196 ◽  
Author(s):  
J Isung ◽  
S Aeinehband ◽  
F Mobarrez ◽  
B Mårtensson ◽  
P Nordström ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cerebrospinal Fluid ◽  
Growth Factor ◽  
Interleukin 8 ◽  
Vascular Endothelial ◽  
Suicide Attempters ◽  
Endothelial Growth Factor

scholarly journals Implications of Vascular Endothelial Growth Factor, sFlt-1, and sTie-2 in Plasma, Serum and Cerebrospinal Fluid during Cerebral Ischemia in Man

2003 ◽  
Vol 23 (1) ◽  
pp. 99-110 ◽  
Author(s):  
Kai-Michael Scheufler ◽  
Joachim Drevs ◽  
Vera van Velthoven ◽  
Petra Reusch ◽  
Joachim Klisch ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cerebrospinal Fluid ◽  
Cerebral Ischemia ◽  
Growth Factor ◽  
Time Course ◽  
Elevated Serum ◽  
Vascular Endothelial ◽  
Concentration Changes ◽  
Endothelial Growth Factor ◽  
Pyruvate Ratio

The relation between cerebral ischemia and local release of angiogenic factors was investigated after subarachnoid hemorrhage (SAH) in humans. Time-dependent concentration-changes of vascular endothelial growth factor (VEGF), sFlt-1 and sTie-2 extracted from plasma, serum, and cerebrospinal fluid (ventricular, cisternal, and lumbar) were analyzed in 15 patients surgically treated for ruptured aneurysms of the anterior circulation (Hunt and Hess grades I-V). Data were related to brain Po2 (Pbro2) and cerebral energy metabolites (extracellular lactate, pyruvate, glutamate, and glycerin concentrations) as well as clinical and radiologic reference data. Delayed impairment of cerebral perfusion secondary to progressive microcirculatory alterations was associated with reduced local Pbro2 and energy metabolism (increased lactate-pyruvate ratio, glutamate and glycerine levels). Elevated serum/plasma and CSF concentrations of VEGF, sFlt-1, and sTie-2 matched the scale of ischemic tissue hypoxia. Excessive VEGF/sFlt-1 and sTie-2 levels were related to Pbro2 values consistently less than 5 mm Hg, glutamate concentrations greater than 300 μmol/L, lactate-pyruvate ratio greater than 300, cerebral infarction, and reduced outcome ( P < 0.01). Delayed microcirculatory impairment was mirrored by distinct elevation of cisternal and arterial VEGF and sFlt-1 concentrations, suggesting local induction of angiogenesis. Arterial levels of VEGF, sFlt-1, and sTie-2 reflect both extent and time course of compensatory, yet clinically inefficient, angiogenesis in the absence of general hypoxia.

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