scholarly journals Erratum: Corrigendum: KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhibin Cui ◽  
Yingjia Shen ◽  
Kenny H. Chen ◽  
Suresh K. Mittal ◽  
Jer-Yen Yang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Peripheral Nerve ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath

scholarly journals KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhibin Cui ◽  
Yingjia Shen ◽  
Kenny H. Chen ◽  
Suresh K. Mittal ◽  
Jer-Yen Yang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Peripheral Nerve ◽  
Treatment Options ◽  
Suppressor Gene ◽  
Driver Genes ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath

Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are a type of rare sarcomas with a poor prognosis due to its highly invasive nature and limited treatment options. Currently there is no targeted-cancer therapy for this type of malignancy. Thus, it is important to identify more cancer driver genes that may serve as targets of cancer therapy. Through comparative oncogenomics, we have found that KANK1 was a candidate tumor suppressor gene (TSG) for human MPNSTs. Although KANK1 is known as a cytoskeleton regulator, its tumorigenic function in MPNSTs remains largely unknown. In this study, we report that restoration of KANK1 in human MPNST cells inhibits cell growth both in human cell culture and xenograft mice by increasing apoptosis. Consistently, knockdown of KANK1 in neurofibroma cells promoted cell growth. Using RNA-seq analysis, we identified CXXC5 and other apoptosis-related genes, and demonstrated that CXXC5 is regulated by KANK1. Knockdown of CXXC5 was found to diminish KANK1-induced apoptosis in MPNST cells. Thus, KANK1 inhibits MPNST cell growth though CXXC5 mediated apoptosis. Our results suggest that KANK1 may function as a tumor suppressor in human MPNSTs, and thus it may be useful for targeted therapy.

scholarly journals Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivothrough suppression of PDGFR-β

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Jun Ohishi ◽  
Mikiko Aoki ◽  
Kazuki Nabeshima ◽  
Junji Suzumiya ◽  
Tamotsu Takeuchi ◽  
...  
Keyword(s):  
Cell Growth ◽  
Peripheral Nerve ◽  
Imatinib Mesylate ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath

Malignant Peripheral Nerve Sheath Tumors of the 8th Cranial Nerve Arising without Prior Irradiation

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Matthew Carlson ◽  
Jeffrey Jacob ◽  
Elizabeth Habermann ◽  
Amy Wagie ◽  
Aditya Raghunathan ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cranial Nerve ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath

MR imaging of benign peripheral nerve sheath tumors

1994 ◽  
Vol 35 (3) ◽  
pp. 282-286 ◽  
Author(s):  
Veli Soderlund ◽  
H. Goranson ◽  
H. C. F. Bauer
Keyword(s):  
Mr Imaging ◽  
Peripheral Nerve ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath
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