scholarly journals NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Sasaki ◽  
Ali Dehnad ◽  
Sarah Fish ◽  
Ai Sato ◽  
Joy Jiang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Mrna Stability ◽  
Ccl2 Mrna

Destabilization of TNF-α mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease

2001 ◽  
Vol 281 (3) ◽  
pp. E420-E429 ◽  
Author(s):  
Kenta Motomura ◽  
Mitsuru Ohata ◽  
Michael Satre ◽  
Hidekazu Tsukamoto
Keyword(s):  
Retinoic Acid ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Mrna Stability ◽  
Transforming Growth Factor ◽  
Cytokine Expression ◽  
Retinol Binding Protein ◽  
Mrna Levels ◽  
Tnf Α ◽  
Specific Ligand

Retinoic acid (RA) inhibits hepatic macrophage (HM) cytokine expression, and retinoids are depleted in alcoholic liver disease (ALD). However, neither the causal link between the two nor the mechanism underlying RA-mediated HM inhibition is known. The aim of the present study was to determine the mechanism of RA-induced inhibition of HM tumor necrosis factor (TNF)-α expression and the relevance of this regulation to ALD. Treatment with all- trans RA (500 nM) caused a 50% inhibition in lipopolysaccharide (LPS)-stimulated TNF-α expression by cultured normal rat HM. The mRNA levels for inducible nitric oxide synthase, interleukin (IL)-6, IL-1α, and IL-1β were also reduced, whereas those for transforming growth factor-β1, MMP-9, and membrane cofactor protein-1 were unaffected. The inhibitory effect on TNF-α expression was reproduced by LG268, a retinoid X receptor (RXR)-specific ligand, but not by TTNPB, an RA receptor (RAR)-specific ligand. RA did not alter LPS-stimulated NF-kB and activation protein-1 binding but significantly decreased TNF-α mRNA stability in HM. HM isolated from the ALD model showed significant decreases in all- trans RA (−48%) and 9- cis RA (−61%) contents, RA response element (RARE) binding, and mRNA levels for RARβ, RXRα, and cytosolic retinol binding protein-1, whereas TNF-α mRNA expression was induced. TNF-α mRNA stability was increased in these cells, and an ex vivo treatment with all- trans RA normalized both RARβ and TNF-α mRNA levels. These results demonstrate the RA-induced destabilization of TNF-α mRNA by cultured HM and the association of RA depletion with increased TNF-α mRNA stability in HM from experimental ALD. These findings suggest that RA depletion primes HM for proinflammatory cytokine expression in ALD, at least in part, via posttranscriptional regulation.

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

Alcohol consumption patterns in heavy drinkers with and without alcoholic liver disease (ALD)

2001 ◽  
Vol 120 (5) ◽  
pp. A117-A117
Author(s):  
K DEAR ◽  
M BRADLEY ◽  
K MCCORMACK ◽  
R PECK ◽  
D GLEESON
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Alcoholic Liver Disease ◽  
Consumption Patterns ◽  
Heavy Drinkers

Altered phosphoethanolamine levels in alcoholic liver disease assessed by in vivo proton-decoupled 31P MR spectroscopic imaging

2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
H SCHLEMMER ◽  
T SAWATZKI ◽  
I DORNACHER ◽  
S SAMMET ◽  
M HELLENSCHMIDT ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

Increased liver stiffness in alcoholic liver disease: Dissecting fibrosis from steatohepatitis

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
S Mueller ◽  
G Millonig ◽  
S Friedrich ◽  
F Stickel ◽  
T Longerich ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Liver Stiffness

Alpha 1 antitrypsin ameliorates experimental alcoholic liver disease and determines patient outcome

2019 ◽  
Author(s):  
C Grander ◽  
B Schäfer ◽  
F Grabherr ◽  
B Enrich ◽  
M Sangineto ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Alpha 1 Antitrypsin
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